Author(s):
Varsha Rawat, Smriti Dewangan, Rakesh Tiwle
Email(s):
smritidewangan88@gmail.com
DOI:
10.52711/0974-360X.2025.00435 
Address:
Varsha Rawat1, Smriti Dewangan2*, Rakesh Tiwle3
1MATS School of Pharmacy, MATS University, Arang, Raipur, Chhattisgarh, India, Pin code – 493441.
2MATS School of Pharmacy, MATS University, Arang, Raipur, Chhattisgarh, India, Pin code – 493441.
3Agrasen College of Pharmacy, Dagania, Gunderdehi, Balod, Chhattisgarh, India, Pin code – 491221.
*Corresponding Author
Published In:
Volume - 18,
Issue - 7,
Year - 2025
ABSTRACT:
This study investigates the potential of Grewia tiliifolia root mucilage as a versatile component in tablet formulations. G. tiliifolia, a plant native to India belonging to the Malvaceae family, presents an attractive natural alternative to synthetic polymers commonly used in pharmaceuticals. This exploration responds to the growing concerns regarding the toxicity, cost, and environmental impact associated with synthetic binders. The mucilage from G. tiliifolia roots was isolated, characterized, and evaluated for its suitability in tablet formulations, specifically focusing on its role as a binder, disintegrant and sustained-release polymer. Granules were prepared with varying concentrations of G. tiliifolia mucilage, and their flow properties were assessed. Paracetamol (PCM) tablets incorporating different concentrations of G. tiliifolia mucilage (GTF1-GTF5) were compared with those containing polyvinylpyrrolidone (PVP) (A1-A5). Various pharmacopoeial standards, including yield and swelling index, were used to evaluate the granules. Granules prepared with G. tiliifolia mucilage exhibited excellent flow properties, meeting pharmacopoeial standards. In vitro dissolution studies revealed that GTF1 tablets achieved 99% drug release within 20 minutes, comparable to the 95% release observed with PVP-based tablets (A1). Furthermore, G. tiliifolia mucilage demonstrated antioxidant activity akin to ascorbic acid, validating its efficacy as a natural binder with performance akin to synthetic alternatives. Grewia tiliifolia root mucilage presents a promising multifunctional ingredient for tablet formulations, serving as an effective binder, disintegrant, gelling agent, and sustained-release polymer. Its successful application in PCM tablets highlights its potential as a viable alternative to synthetic polymers, addressing concerns regarding toxicity, cost, and environmental impact in pharmaceutical formulations.
Cite this article:
Varsha Rawat, Smriti Dewangan, Rakesh Tiwle. Characterization, Antimicrobial Activity and Antioxidant Properties of Grewia tiliifolia Root Mucilage as a Binder Excipient. Research Journal of Pharmacy and Technology. 2025;18(7):3037-4. doi: 10.52711/0974-360X.2025.00435
Cite(Electronic):
Varsha Rawat, Smriti Dewangan, Rakesh Tiwle. Characterization, Antimicrobial Activity and Antioxidant Properties of Grewia tiliifolia Root Mucilage as a Binder Excipient. Research Journal of Pharmacy and Technology. 2025;18(7):3037-4. doi: 10.52711/0974-360X.2025.00435 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-7-15
REFERENCES:
1. Dicson SM, Samuthirapandi M, Govindaraju A, Kasi PD. Evaluation of in vitro and in vivo safety profile of the Indian traditional medicinal plant Grewia tiliaefolia. Regulatory Toxicology and Pharmacology. 2015; Oct 1; 73(1): 241-7. https://doi.org/10.1016/j.yrtph.2015.07.011
2. Haridas R, Sumathi P, Thomas B. Phytochemical Investigation By Using Tender Leaf Part Of Grewia Tiliifolia Vahl. Kongunadu Research Journal. 2017; Dec 30; 4(3): 68-70. https://doi.org/10.26524/krj234
3. Mbosso EJ, Wintjens R, Lenta BN, Ngouela S, Rohmer M, Tsamo E. Chemical constituents from Glyphaea brevis and Monodora myristica: chemotaxonomic significance. Chemistry and Biodiversity. 2013; Feb; 10(2): 224-32. https://doi.org/10.1002/cbdv.201100378
4. Ahamed MB, Krishna V, Dandin CJ. In vitro antioxidant and in vivo prophylactic effects of two γ-lactones isolated from Grewia tiliaefolia against hepatotoxicity in carbon tetrachloride intoxicated rats. European Journal of Pharmacology. 2010; Apr 10; 631(1-3): 42-52. https://doi.org/10.1016/j.ejphar.2009.12.034
5. Kuruvilla J, Anilkumar M. Pharmacognostic and Phytochemical Evaluation of the bark of Grewia tiliifolia Vahl. Pharmacognosy Journal. 2020; Sep 1; 12(5). https://doi.org/10.5530/pj.2020.12.137
6. Badami S, Gupta MK, Ramaswamy S, Rai SR, Nanjaian M, Bendell DJ, Subban R, Bhojaraj S. Determination of betulin in Grewia tiliaefolia by HPTLC. Journal of Separation Science. 2004; Jan; 27(1‐2): 129-31. https://doi.org/10.1002/jssc.200301599
7. Rajavel T, Mohankumar R, Archunan G, Ruckmani K, Devi KP. Beta sitosterol and Daucosterol (phytosterols identified in Grewia tiliaefolia) perturbs cell cycle and induces apoptotic cell death in A549 cells. Scientific Reports. 2017; Jun 13; 7(1): 3418. https://doi.org/10.1038/s41598-017-03511-4
8. Takayama K, Sato T, Sato K, Todo H, Obata Y, Sugibayashi K. Prediction of tablet characteristics based on sparse modeling for residual stresses simulated by the finite element method incorporating Drucker-Prager cap model. Journal of Drug Delivery Science and Technology. 2019; Aug 1; 52: 1021-31. https://doi.org/10.1016/j.jddst.2019.06.017
9. Janczura M, Sip S, Cielecka-Piontek J. The development of innovative dosage forms of the fixed-dose combination of active pharmaceutical ingredients. Pharmaceutics. 2022; Apr 11; 14(4): 834. https://doi.org/10.3390/pharmaceutics14040834
10. Apeji YE, Olayemi OJ, Anyebe SN, Oparaeche C, Orugun OA, Olowosulu AK, Oyi AR. Impact of binder as a formulation variable on the material and tableting properties of developed co-processed excipients. SN Applied Sciences. 2019; Jun; 1: 1-2. https://doi.org/10.1007/s42452-019-0585-2
11. Ilango KB, Gowthaman S, Seramaan KI, Chidambaram K, Bayan MF, Rahamathulla M, Balakumar C. Mucilage of Coccinia grandis as an efficient natural polymer-based pharmaceutical excipient. Polymers. 2022; Jan 5; 14(1): 215. https://doi.org/10.3390/polym14010215
12. Amiri MS, Mohammadzadeh V, Yazdi ME, Barani M, Rahdar A, Kyzas GZ. Plant-based gums and mucilages applications in pharmacology and nanomedicine: a review. Molecules. 2021; Mar 22; 26(6): 1770. https://doi.org/10.3390/molecules26061770
13. Kreitschitz A, Kovalev A, Gorb SN. Plant seed mucilage as a glue: Adhesive properties of hydrated and dried-in-contact seed mucilage of five plant species. International Journal of Molecular Sciences. 2021; Feb 1; 22(3): 1443. https://doi.org/10.3390/ijms2203144
14. Malabadi RB, Kolkar KP, Chalannavar RK. Natural plant gum exudates and mucilage: pharmaceutical updates. Int J Innov Sci Res Rev. 2021; 3(10): 1897-912. https://doi.org/10.20546/ijcrbp.2021.806.001
15. Shaikh MA, Gilhotra R, Pathak S, Mathur M, Iqbal HM, Joshi N, Gupta G. Current update on psyllium and alginate incorporate for interpenetrating polymer network (IPN) and their biomedical applications. International Journal of Biological Macromolecules. 2021; Nov 30; 191: 432-44. https://doi.org/10.1016/j.ijbiomac.2021.09.115
16. Ahuja M, Kumar A, Yadav P, Singh K. Mimosa pudica seed mucilage: Isolation; characterization and evaluation as tablet disintegrant and binder. International Journal of Biological Macromolecules. 2013; Jun 1; 57: 105-10. https://doi.org/10.1016/j.ijbiomac.2013.03.004
17. Yasuyuki M, Kunihiro K, Kurissery S, Kanavillil N, Sato Y, Kikuchi Y. Antibacterial properties of nine pure metals: a laboratory study using Staphylococcus aureus and Escherichia coli. Biofouling. 2010; Oct 11; 26(7): 851-8. https://doi.org/10.1080/08927014.2010.527000
18. Rawat V, Jain V. Formulation, Optimization And Characterization Of Ellagic Acid Phyto-Vesicular System For Bioavailability Enhancement. Indian Drugs. 2023; Jul 1; 60(7). https://doi.org/10.53879/id.60.07.13552
19. Pasha AZ, Bukhari SA, El Enshasy HA, El Adawi H, Al Obaid S. Compositional analysis and physicochemical evaluation of date palm (Phoenix dactylifera L.) mucilage for medicinal purposes. Saudi Journal of Biological Sciences. 2022; Feb 1; 29(2): 774-80. https://doi.org/10.1016/j.sjbs.2021.10.048
20. Qadir U, Paul VI, Ganesh P. Preliminary phytochemical screening and in vitro antibacterial activity of Anamirta cocculus (Linn.) seeds. Journal of King Saud University-Science. 2015; Apr 1; 27(2): 97-104. https://doi.org/10.1016/j.jksus.2014.04.004
21. Desta KH, Tadese E, Molla F. Physicochemical characterization and evaluation of the binding effect of Acacia etbaica Schweinf gum in granule and tablet formulations. BioMed Research International. 2021; 2021; (1): 5571507. https://doi.org/10.1155/2021/5571507
22. Yayehrad AT, Marew T, Matsabisa M, Wondie GB. Physicochemical characterization and evaluation of Ficus Vasta Gum as a Binder in Tablet Formulation. BioMed Research International. 2023; 2023(1): 8852784. https://doi.org/10.1155/2023/8852784
23. Ajala TO, Akin-Ajani OD, Ihuoma-Chidi C, Odeku OA. Chrysophyllum albidum mucilage as a binding agent in paracetamol tablet formulations. Journal of Pharmaceutical Investigation. 2016; Oct; 46: 565-73. https://doi.org/10.1007/s40005-016-0266-8
24. Malik MK, Kumar V, Singh J, Kumar P. Efficiency of phosphorylated mandua starch in matrix tablet for targeted release of mesalamine in colon. Journal of Drug Delivery Science and Technology. 2023; Mar 1; 81: 104251. https://doi.org/10.1016/j.jddst.2023.104251
25. Zhang W, Xiao C, Xiao Y, Tian B, Gao D, Fan W, Li G, He S, Zhai G. An overview of in vitro dissolution testing for film dosage forms. Journal of Drug Delivery Science and Technology. 2022; May 1; 71: 103297. https://doi.org/10.1016/j.jddst.2022.103297
26. Oh S, Kim DY. Characterization, antioxidant activities, and functional properties of mucilage extracted from corchorus olitorius L. Polymers. 2022; Jun 18; 14(12): 2488. https://doi.org/10.3390/polym14122488
27. Lungoci AL, Turin-Moleavin IA, Corciova A, Mircea C, Arvinte A, Fifere A, Marangoci NL, Pinteala M. Multifunctional magnetic cargo-complexes with radical scavenging properties. Materials Science and Engineering: C. 2019; Jan 1; 94: 608-18. https://doi.org/10.1016 /j.msec.2018.10.013
28. Graça C, Edelmann M, Raymundo A, Sousa I, Coda R, Sontag-Strohm T, Huang X. Yoghurt as a starter in sourdough fermentation to improve the technological and functional properties of sourdough-wheat bread. Journal of Functional Foods. 2022; Jan 1; 88: 104877. https://doi.org/10.1016/j.jff.2021.104877
29. Surh J, Koh E. Effects of four different cooking methods on anthocyanins, total phenolics and antioxidant activity of black rice. Journal of the Science of Food and Agriculture. 2014; Dec; 94(15): 3296-304. https://doi.org/10.1002/jsfa.6690