Author(s):
Nuri Ari Efiana, Khusnul Khotimah R, Ananda CPDP Irawan, Ernidawati, Dzakira Tsabita Atmaji, Farahidah Muhamed, Fatema Tuz Zohera, Adi Permadi, Iis Wahyuningsih
Email(s):
iis.wahyuningsih@pharm.uad.ac.id
DOI:
10.52711/0974-360X.2025.00421 
Address:
Nuri Ari Efiana1, Khusnul Khotimah R1, Ananda CPDP Irawan1, Ernidawati1, Dzakira Tsabita Atmaji1, Farahidah Muhamed3, Fatema Tuz Zohera3, Adi Permadi2, Iis Wahyuningsih1*
1Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Ahmad Dahlan, Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta 55164, Indonesia.
2Department of Chemical Engineering, Faculty of Industrial Technology, Universitas Ahmad Dahlan, Jl. Ring Road Selatan, Tamanan, Banguntapan, Bantul Yogyakarta 55166, Indonesia.
3Department of Pharmaceutical Technology, Kulliyyah of Pharmacy, International Islamic University, Malaysia.
*Corresponding Author
Published In:
Volume - 18,
Issue - 7,
Year - 2025
ABSTRACT:
Capsanthin exhibits potential therapeutic effects for various diseases such as cancer, diabetes, and heart disease. However, capsanthin has several limitations including its lipophilic nature and instability against oxygen, light, and high temperatures. To overcome this problem, a drug delivery system for capsanthin is needed. Therefore, this research aimed to develop a nanostructured lipid carrier (NLC) as a carrier for capsanthin. The confirmation of capsanthin in capsanthin extract was carried out using FTIR and TLC analysis. The method used for the NLC preparation was a modified solvent injection method. The optimization of NLC formulations was performed using various liquid lipids followed by measuring the properties of NLC including particle size and zeta potential. The selected formulation was characterized regarding the loading capacity, transmission electron microscopy (TEM) as well as release study. The results of FTIR and TLC confirmed the presence of capsanthin in the extract. The formulation optimization showed that the capsanthin-loaded NLC using wheat germ oil (F1) as a liquid lipid provided various properties including the particle size, zeta potential, and loading capacity of 266,5±65, 3nm; -15,0±0,4mV and 22±4%, respectively. Furthermore, a release study exhibited that capsanthin could be incorporated into NLC characterized by significantly slower capsanthin release compared to unloaded capsanthin. In conclusion, NLC can be used as a promising capsanthin carrier and applied in drug delivery systems.
Cite this article:
Nuri Ari Efiana, Khusnul Khotimah R, Ananda CPDP Irawan, Ernidawati, Dzakira Tsabita Atmaji, Farahidah Muhamed, Fatema Tuz Zohera, Adi Permadi, Iis Wahyuningsih. Development of Nanostructured Lipid Carrier (NLC) as a Promising Carrier for Capsanthin. Research Journal of Pharmacy and Technology. 2025;18(7): 2941-7. doi: 10.52711/0974-360X.2025.00421
Cite(Electronic):
Nuri Ari Efiana, Khusnul Khotimah R, Ananda CPDP Irawan, Ernidawati, Dzakira Tsabita Atmaji, Farahidah Muhamed, Fatema Tuz Zohera, Adi Permadi, Iis Wahyuningsih. Development of Nanostructured Lipid Carrier (NLC) as a Promising Carrier for Capsanthin. Research Journal of Pharmacy and Technology. 2025;18(7): 2941-7. doi: 10.52711/0974-360X.2025.00421 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-7-1
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