Author(s):
Nor Farid Mohd Noor, U.S. Mahadeva Rao1, Mohd Faris Mohd Husin2, Zul Izhar Ismail2, Nurul Aiman Mohd Yusoff, Sharifah Emelia Tuan Sharif, Suganya Mahadeva Rao, Lee Wan Zhen, Shrinithi MR, Siddeshwaran MR, M. Bala Sundaram, Kalandar Ameer
Email(s):
faridmnoor@unisza.edu.my
DOI:
10.52711/0974-360X.2025.00411 
Address:
Nor Farid Mohd Noor1*, U.S. Mahadeva Rao1, Mohd Faris Mohd Husin2, Zul Izhar Ismail2, Nurul Aiman Mohd Yusoff2, Sharifah Emelia Tuan Sharif3, Suganya Mahadeva Rao4, Lee Wan Zhen5, Shrinithi MR6, Siddeshwaran MR7, M. Bala Sundaram8, Kalandar Ameer8
1Faculty of Medicine, Universiti Sultan Zainal Abidin (UniSZA), Kampus Perubatan, Jalan Sultan Mahmud, 20400 Kuala Terengganu, Terengganu Darul Iman, Malaysia.
2Department of Anatomy, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia,
3Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan,
4PEOPLE’S College of Dental Sciences and Research Centre, PEOPLE’S University, MP, Bhopal, India.
5Department of Wellness, Faculty of Hospitality, Tourism and Wellness (FHPK), Universiti Malaysia Kelantan, Kampus Kota, Kelantan, Malaysia.
6Faculty of Dental Surgery, Thai Moogambigai Dental College and Hospital, Chennai, Tamil Nadu, India.
7Facul
Published In:
Volume - 18,
Issue - 6,
Year - 2025
ABSTRACT:
Introduction: Neurogenesis in the mammal exists in several neurogenic areas such as subventricular region, subgranular zone of dentate gyrus of the brain and central canal of the spinal cord. The existence of dividing cells in these areas can be demonstrated with immunohistochemistry marker such as Ki67. It is possible that there is an existence of other proliferative areas such in the oral cavity. Objectives: To identify the Ki67-expressing cells in the spinal cord, and oral region such as tongue. Methodology: Sprague Dawley rats were used, and the tissues from the spinal cord, and tongue were taken and stained using Ki67. The slides were reviewed under light microscope. Results: The tissues from the spinal cord (lamina X of the grey matter), and areas around oral cavity such as tongue were stained positive with Ki67 marker. Conclusion: The Ki67-expressing cells were identified in the oral cavity such as taste buds, thyroglossal duct and ganglion.
Cite this article:
Nor Farid Mohd Noor, U.S. Mahadeva Rao1, Mohd Faris Mohd Husin2, Zul Izhar Ismail2, Nurul Aiman Mohd Yusoff, Sharifah Emelia Tuan Sharif, Suganya Mahadeva Rao, Lee Wan Zhen, Shrinithi MR, Siddeshwaran MR, M. Bala Sundaram, Kalandar Ameer. The Ki67-Expressing cells: Hidden gems in the Oral Cavity of adult Mammal. Research Journal of Pharmacy and Technology. 2025;18(6):2860-3. doi: 10.52711/0974-360X.2025.00411
Cite(Electronic):
Nor Farid Mohd Noor, U.S. Mahadeva Rao1, Mohd Faris Mohd Husin2, Zul Izhar Ismail2, Nurul Aiman Mohd Yusoff, Sharifah Emelia Tuan Sharif, Suganya Mahadeva Rao, Lee Wan Zhen, Shrinithi MR, Siddeshwaran MR, M. Bala Sundaram, Kalandar Ameer. The Ki67-Expressing cells: Hidden gems in the Oral Cavity of adult Mammal. Research Journal of Pharmacy and Technology. 2025;18(6):2860-3. doi: 10.52711/0974-360X.2025.00411 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-6-64
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