Author(s):
Safrida Safrida, M. Adlim, Ismiranda Ismiranda, Mustafa Sabri, Basri A. Gani
Email(s):
saf_rida@usk.ac.id
DOI:
10.52711/0974-360X.2025.00395 
Address:
Safrida Safrida1*, M. Adlim2, Ismiranda Ismiranda1, Mustafa Sabri3, Basri A. Gani4
1Department of Biology Education, Faculty of Teacher Training and Education, Universitas Syiah Kuala, Darussalam, Banda Aceh, Aceh, Indonesia.
2Chemistry Department, Faculty of Teacher Training and Education, Universitas Syiah Kuala, Darussalam, Banda Aceh, Aceh, Indonesia.
3Department of Animal Anatomy, Faculty of Veterinary Medicine, Universitas Syiah Kuala, Darussalam, Banda Aceh, Aceh, Indonesia.
4Department of Oral Biology, Faculty of Dentistry, Universitas Syiah Kuala, Darussalam, Banda Aceh, Aceh, Indonesia.
*Corresponding Author
Published In:
Volume - 18,
Issue - 6,
Year - 2025
ABSTRACT:
Hypercholesterolemia impacts blood vessel blockage and triggers atherosclerosis and coronary heart disease. The Tamarindus indica L (T. indica) contains relatively high antioxidant compounds, which are reported to have the potential to prevent hypercholesterolemia. To analyze the effect of ethanol extract of T. indica on reducing total Mus musculus cholesterol and histopathological changes of the liver and coronary arteries. The treatment group consisted of 24 Mus musculus, divided into three concentrations and positive and negative controls. Each group comprised four participants. This study investigated the antioxidant content using the DPPH method, analyzed total cholesterol levels with Autocheck Cholesterol, and evaluated changes in the liver and coronary arteries through H and E staining. IC50 T. indica has an antioxidant content of 10.45µg/mL. T. indica L had the effect of reducing total cholesterol, High-density lipoprotein (HDL), Low-density lipoprotein (LDL), and triglyceride, respectively, in the 35mg group (decreased 16%: increased 24%: decreased 30%; decreased 29%), 175mg (decreased 36%:increased 24%; decreased 32%; decreased 8% ), and a group of 350mg (decreased 40%: increased 28%; decreased 39%). Histopathologically, these three groups prevented fatty infiltration and degeneration in the liver and coronary arteries. T. indica, possessing a comparatively elevated concentration of antioxidants, can decrease overall blood cholesterol levels, LDL cholesterol, and triglycerides while concurrently increasing HDL cholesterol. It is evidenced by reduced degeneration and fat infiltration in the liver and heart when examined under microscopic analysis.
Cite this article:
Safrida Safrida, M. Adlim, Ismiranda Ismiranda, Mustafa Sabri, Basri A. Gani. Effect of Tamarindus indica L on Metabolism Changes of Hypercholesterolemia of Mus musculus. Research Journal of Pharmacy and Technology. 2025;18(6):2756-5. doi: 10.52711/0974-360X.2025.00395
Cite(Electronic):
Safrida Safrida, M. Adlim, Ismiranda Ismiranda, Mustafa Sabri, Basri A. Gani. Effect of Tamarindus indica L on Metabolism Changes of Hypercholesterolemia of Mus musculus. Research Journal of Pharmacy and Technology. 2025;18(6):2756-5. doi: 10.52711/0974-360X.2025.00395 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-6-48
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