Author(s):
Pushpa P. Gupta, Akhilesh Kumar Sahu, Amit Roy, Shashikant Chandrakar
Email(s):
sahuakhikhilesh11@gmail.com
DOI:
10.52711/0974-360X.2025.00386 
Address:
Pushpa P. Gupta1, Akhilesh Kumar Sahu2*, Amit Roy1, Shashikant Chandrakar3
1Chhatrapati Shivaji Institute of Pharmacy, Durg (CG) – 49.
2Sanskar City College of Pharmacy, Rajnandgaon (CG) – 491441.
3Columbia Institute of Pharmacy, Raipur (CG) – 493111.
*Corresponding Author
Published In:
Volume - 18,
Issue - 6,
Year - 2025
ABSTRACT:
This research assessed the antidiabetic efficacy of mucilage derived from Hibiscus sabdariffa leaves in streptozotocin (STZ)-induced diabetic rats. The mucilage was orally administered at doses of 300 mg/kg and 600 mg/kg for a duration of 21 days, with metformin (65mg/kg) serving as a positive control. The evaluated key indicators comprised overnightfasting blood glucose (FBG), body weight, lipid composition, haematological characteristics, and antioxidant activity. The results indicated a substantial 30% decrease in fasting blood glucose levels in the 600 mg/kg mucilage group relative to the diabetes controls. Furthermore, the mucilage enhanced body weight stability and lipid profiles, resulting in significant reductions in overall cholesterol (18.9%), triglycerides (27.1%), and LDL, while simultaneously increasing HDL. The mucilage showed no toxicity at doses up to 2000 mg/kg and did not negatively impact haematological markers. The phytochemical examination revealed the presence of carbohydrates, polysaccharides, and phenols (55.41±0.6mg GAE/g) in the plant. The DPPH assay indicated modest antioxidant activity (IC50 = 79.12µg/ml). The findings indicate that Hibiscus sabdariffa leaf mucilage exhibits notable antidiabetic and hypolipidemic characteristics, possibly due to its polysaccharide and phenolic constituents, and may function as a safe, natural medicinal agent for diabetes control.
Cite this article:
Pushpa P. Gupta, Akhilesh Kumar Sahu, Amit Roy, Shashikant Chandrakar. Uncovering The Antidiabetic Potential of Hibiscus sabdariffa leaf Mucilage: A Natural approach to Managing Glycaemic and Lipid Levels. Research Journal of Pharmacy and Technology. 2025;18(6):2686-6. doi: 10.52711/0974-360X.2025.00386
Cite(Electronic):
Pushpa P. Gupta, Akhilesh Kumar Sahu, Amit Roy, Shashikant Chandrakar. Uncovering The Antidiabetic Potential of Hibiscus sabdariffa leaf Mucilage: A Natural approach to Managing Glycaemic and Lipid Levels. Research Journal of Pharmacy and Technology. 2025;18(6):2686-6. doi: 10.52711/0974-360X.2025.00386 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-6-39
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