Author(s):
Rajnish Kumar Malik, Amit Kumar Sharma, Vikramdeep Monga, Tanveer Naved
Email(s):
tnaved@amity.edu
DOI:
10.52711/0974-360X.2025.00379 
Address:
Rajnish Kumar Malik1, Amit Kumar Sharma1, Vikramdeep Monga2, Tanveer Naved1*
1Amity Institute of Pharmacy, Amity University, Noida Campus, Uttar Pradesh, India - 201313.
2Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Ghudda - 151401, Bathinda, Punjab, India.
*Corresponding Author
Published In:
Volume - 18,
Issue - 6,
Year - 2025
ABSTRACT:
The present work examined the neuroprotective and anti-Parkinsonian properties of derivatives of hydrazide and carboxylate. The synthesized compounds structures were confirmed by analysing their spectrum data. It was shown that both drugs worked well against the oxidative stress and catalepsy induced by Rotenone and Paraquat in mice. Various derivatives of Carboxylates and Hydrazide were synthesized and screened for potential anti-parkinsonian activity through molecular docking study and two derivatives i.e., SH-4 and SH-9 were selected for further in-vivo activity. The PQ model provided a suitable method for examining neuropsychiatric dysfunction, particularly changes in depressive and anxiety-like behavior. The synthesized compounds, SH-4 and SH-9 represented anti-parkinsonian activity comparable to standard drug.
Cite this article:
Rajnish Kumar Malik, Amit Kumar Sharma, Vikramdeep Monga, Tanveer Naved. Design, Synthesis, and Neuroprotective effects of Carboxylate and Hydrazide derivatives against Paraquat and Rotenone Induced Parkinson’s Disease. Research Journal of Pharmacy and Technology. 2025;18(6):2639-6. doi: 10.52711/0974-360X.2025.00379
Cite(Electronic):
Rajnish Kumar Malik, Amit Kumar Sharma, Vikramdeep Monga, Tanveer Naved. Design, Synthesis, and Neuroprotective effects of Carboxylate and Hydrazide derivatives against Paraquat and Rotenone Induced Parkinson’s Disease. Research Journal of Pharmacy and Technology. 2025;18(6):2639-6. doi: 10.52711/0974-360X.2025.00379 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-6-32
REFERENCE:
1. Armstrong MJ. Okun MS. Diagnosis and treatment of Parkinson disease: A review. JAMA. 2020; 323(6): 548-560.
2. Dorsey ER. Elbaz A. Nichols E. Abbasi N. Abd-Allah F. Abdelalim A. Adsuar JC. Ansha MG. Brayne C. Choi JY. Collado-Mateo D. Global, regional, and national burden of Parkinson's disease, 1990–2016: A systematic analysis for the global burden of disease study 2016. The Lancet Neurology. 2018; 17(11): 939-53.
3. Sumit Kumar, Pooja, Dinesh Kumar, Sachin Gulia, Rajni, Megha Thakur. Traumatic Brain Injury: Role in Induction and Progression of Neurodegenerative Disorders. Research Journal of Pharmacy and Technology. 2024; 17(4):1909-5.
4. Li S. Le W. Milestones of Parkinson’s disease research: 200 years of history and beyond. Neuroscience Bulletin. 2017; 33:598-602.
5. Przedborski S. The two-century journey of Parkinson disease research. Nature Reviews Neuroscience. 2017; 18(4): 251-9.
6. Jhakeshwar Prasad, Ashish Kumar Netam, Ritika Singh, Manisha Sahu, Trilochan Satapathy, S. Prakash Rao, Purnima Baghel, Mahendra Kumar Sahu. Therapeutic Approaches for the Management of Parkinson’s Disease. Res. J. Pharmacology and Pharmacodynamics. 2019; 11(1): 46-52.
7. Aryal S. Skinner T. Bridges B. Weber JT. The pathology of Parkinson’s disease and potential benefit of dietary polyphenols. Molecules. 2020; 25(19): 4382.
8. Dickson DW. Parkinson’s disease and parkinsonism: neuropathology. Cold Spring Harbor Perspectives in Medicine. 2012; 2(8): 1-16.
9. Ejaz S. Nadeem H. Paracha RZ. Sarwar S. Ejaz S. Designing, synthesis and characterization of 2-aminothiazole-4-carboxylate Schiff bases; antimicrobial evaluation against multidrug resistant strains and molecular docking. Bmc Chemistry. 2019; 13: 1-3.
10. Tanner CM. Goldman SM. Ross GW. Grate SJ. The disease intersection of susceptibility and exposure: Chemical exposures and neurodegenerative disease risk. Alzheimer's and Dementia. 2014; 10: 213-25.
11. Furlong M. Tanner CM. Goldman SM. Bhudhikanok GS. Blair A. Chade A. Comyns K. Hoppin JA. Kasten M. Korell M. Langston JW. Protective glove use and hygiene habits modify the associations of specific pesticides with Parkinson’s disease. Environment International. 2015; 75: 144-50.
12. Goldman SM. Environmental toxins and Parkinson’s disease. Annual Review of Pharmacology and Toxicology. 2014; 54: 141-64.
13. Bapu R. Thorat, Bhusan Nazirkar, Vaishali B. Thorat, Kishor More, Ravindra Jagtap, Ramesh Yamgar. Synthesis, SAR, Molecular Docking and Anti-TB study of 3-Hydroxy-1-Benzofuran-2-Carbohydrazide. Asian J. Research Chem. Mar., 2016; 9(3): 116-126.
14. Sudhakar P, Poorana Pushkalai S, Sabarinath C, Priyadharshini S, Haripriya S . Molecular docking and synthesis of 1, 2, 4 - triazin analogue of diclofenac as potential ligand for parkinson’s. Res. J. Pharmacology and Pharmacodynamics. 2018; 10(1): 08-12.
15. Pathania A. Kumar R. Sandhir R. Hydroxytyrosol as anti-parkinsonian molecule: Assessment using in-silico and MPTP-induced parkinson’s disease model. Biomedicine and Pharmacotherapy. 2021; 139: 1-16.
16. Sharma S. Kumar P. Deshmukh R. Neuroprotective potential of spermidine against rotenone induced parkinson's disease in rats. Neurochemistry International. 2018; 116: 104-11.
17. Kumar H. Kawai T. Akira S. Pathogen recognition by the innate immune system. International Reviews of Immunology. 2011; 30(1): 16-34.
18. Ohkawa H. Ohishi N. Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical Biochemistry. 1979; 95(2): 351-8. https://doi.org/10.1016/0003-2697(79)90738-3.
19. Ojha PS. Biradar PR. Tubachi S. Patil VS. Evaluation of neuroprotective effects of Canna indica L against aluminium chloride induced memory impairment in rats. Advances in Traditional Medicine. 2022; 23: 539-556.
20. Puka-Sundvall M. Wallin C. Gilland E. Hallin U. Wang X. Sandberg M. Karlsson JO. Blomgren K. Hagberg H. Impairment of mitochondrial respiration after cerebral hypoxia–ischemia in immature rats: relationship to activation of caspase-3 and neuronal injury. Developmental Brain Research. 2000; 125(1-2): 43-50.
21. Gupta D. Kurhe Y. Radhakrishnan M. Antidepressant effects of insulin in streptozotocin induced diabetic mice: modulation of brain serotonin system. Physiology and Behavior. 2014; 129: 73-8.
22. V Nuthan Kumar Babu, Navneet Khurana. A Review on Mitochondrial Dysfunction and Oxidative stress due to Complex-I in Parkinson Disease. Research Journal of Pharmacology and Pharmacodynamics. 2021; 13(4): 167-0.
23. Himadri Shekhaar Baul, Muniyan Rajiniraja. Favorable binding of Quercetin to α-Synuclein as potential target in Parkinson disease: An Insilico approach. Research J. Pharm. and Tech. 2018; 11(1): 203-206
24. Neveda Baskeran. Iron Deficiency and Brain Disorders. Research J. Pharm. and Tech. 2014; 7(3): 352-353.