Author(s):
Asriullah Jabbar, Wahyuni, Fadhliyah Malik, Nasrudin, Jihan Yasida Azzahra, Muhammad Ilyas Y, Hasyrul Hamzah, Sylvia Utami Tunjung Pratiwi
Email(s):
sylvia_pratiwi@ugm.ac.id
DOI:
10.52711/0974-360X.2025.00376 
Address:
Asriullah Jabbar1,2,7, Wahyuni2, Fadhliyah Malik2, Nasrudin2, Jihan Yasida Azzahra2, Muhammad Ilyas Y2,3, Hasyrul Hamzah4,7, Sylvia Utami Tunjung Pratiwi5,6,7*
1Post Doctoral Program, Faculty of Pharmacy, Universitas Gadjah Mada, Jl. Farmako Sekip Utara, Yogyakarta, 55281, Indonesia.
2Faculty of Pharmacy, Universitas Halu Oleo, Jl. H.E.A Mokodompit, Kendari, 93232, Indonesia,
3Politeknik Bina Husada Kendari, 93117, Indonesia.
4Faculty of Pharmacy, Universitas Muhammadiyah Kalimantan Timur, Samarinda, Kalimantan, Timur 75124, Indonesia.
5Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, 55281 Indonesia.
6Medical Plants and Natural Products Research Center Faculty of Pharmacy, Universitas Gadjah Mada Jl. Farmako Sekip Utara, Yogyakarta, Indonesia, 55281.
7Indonesia Biofilm Research Collaboration Center (IBRCC), Jl. Farmako Sekip Utara, Yogyakarta, Indonesia, 55281.
*Corresponding Author
Published In:
Volume - 18,
Issue - 6,
Year - 2025
ABSTRACT:
Songa Songa wood (Strychnos ligustrida) is one of the endemic plants of Sumbawa island, West Nusa Tenggara province, Indonesia. This plant is widely used by the local community as a tonic, wound medicine, antimalarial, joint pain, diabetes, and anti-inflammatory. One of the causes of inflammation is free radicals. The amount of free radicals causes oxidative stress which can cause inflammation. The purpose of this study was to determine the activity of free radical Scavenger (FRAP) and the effect of giving methanol extract of songga wood (Strychnos ligustrina) on reducing IL-1ß levels (anti-inflammatory) by Elisa method. Methanol extract of songga wood (S. ligustrina) was macerated with methanol (3 x 24hours). The test animals were divided into 6 groups: the normal group, negative control (Na-CMC 0.5%), positive control (Diclofenac sodium), and treatment with 3 dose variations of 50, 100, and 200mg/kgBW. The antioxidant activity test results of songga wood methanol extract IC50 78.05µg/mL and quercetin as a comparative control is 6.72µg/mL. The results of the anti-inflammatory activity test showed the value of IL-1ß levels at doses of 50, 100, and 200mg/kgBW, namely 470.30, 205.99 and 135.75pg/mL, respectively. This study concludes that methanol extract of songga wood has strong antioxidant activity and has potential as an anti-inflammatory, with the most effective dose reducing IL-1ß levels at 200mg/kgBW (p> 0.05).
Cite this article:
Asriullah Jabbar, Wahyuni, Fadhliyah Malik, Nasrudin, Jihan Yasida Azzahra, Muhammad Ilyas Y, Hasyrul Hamzah, Sylvia Utami Tunjung Pratiwi. Effect of Songga Wood Methanol Extract (Strychnos ligustrina) on reducing IL-1ꞵ levels and Free radical scavenger by FRAP method. Research Journal of Pharmacy and Technology. 2025;18(6):2620-6. doi: 10.52711/0974-360X.2025.00376
Cite(Electronic):
Asriullah Jabbar, Wahyuni, Fadhliyah Malik, Nasrudin, Jihan Yasida Azzahra, Muhammad Ilyas Y, Hasyrul Hamzah, Sylvia Utami Tunjung Pratiwi. Effect of Songga Wood Methanol Extract (Strychnos ligustrina) on reducing IL-1ꞵ levels and Free radical scavenger by FRAP method. Research Journal of Pharmacy and Technology. 2025;18(6):2620-6. doi: 10.52711/0974-360X.2025.00376 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-6-29
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