Author(s):
Akmaljon D. Raximov, Mamurjon K. Pozilov, Nazokatxon X. Yakubova, Makhmud B. Gafurov, Kuralbay Zh. Rezhepov, Muzaffar I. Asrarov, Zafarjon M. Ernazarov
Email(s):
akmaljon.raximov.94@list.ru
DOI:
10.52711/0974-360X.2025.00368 
Address:
Akmaljon D. Raximov1*, Mamurjon K. Pozilov2, Nazokatxon X. Yakubova3, Makhmud B. Gafurov3, Kuralbay Zh. Rezhepov3, Muzaffar I. Asrarov1, Zafarjon M. Ernazarov4
1Institute of Biophysics and Biochemistry at The National University of Uzbekistan. 100174, Tashkent City, Almazar District, Students Town, University St., 174.
2National University of Uzbekistan. Tashkent, Uzbekistan. 100174, Tashkent City, Almazar District, Students Town, University St., 174.
3 The Institute of Bioorganic Chemistry Named After A.S. Sadikov. 100125, Tashkent City, Mirzo Ulugbek District, Mirzo Ulugbek Avenue, 83.
4Kokand State Pedagogical Institute. Kokand, Uzbekistan. 150700, Turon Str., 23.
*Corresponding Author
Published In:
Volume - 18,
Issue - 6,
Year - 2025
ABSTRACT:
In this article, the effect of the diazoimino derivative gossypol [(((4,4'-bis((1,5-dimetil-3-okso-2-fenil-2,3-digidro-1H-pirazol-4-il) diazenil)-1,1',6,6'-tetragidroksi-5,5'-diizopropil-3,3'-dimetil-7,7'-diokso-[2,2'-binaftalin]-8,8'(7H,7'H)-diiliden)bis(metanililiden))bis(azanedil))bis(etan-2,1-diyl) bis(vodorod sulfat))] (YaN-1) on the swelling of cardiac mitochondria, the conductivity of the mitoKATP channel, and the lipid peroxidation process were determined by recording changes in optical density on a spectrophotometer. Polyphenol YaN-1, diazoimino derivative of gossypol, inhibited mPTP in rat heart mitochondria, causing an increase in the activity of mitoKATP channels compared to the control. It was established that the polyphenol YaN-1 has antioxidant properties, reducing the intensity of the lipid oxidation process in the inner and outer membranes of mitochondria.
Cite this article:
Akmaljon D. Raximov, Mamurjon K. Pozilov, Nazokatxon X. Yakubova, Makhmud B. Gafurov, Kuralbay Zh. Rezhepov, Muzaffar I. Asrarov, Zafarjon M. Ernazarov. Effect of polyphenol YaN-1, a Diazoimino derivative of gossypol, on the membrane of Cardiac Mitochondria. Research Journal of Pharmacy and Technology. 2025;18(6):2575-1. doi: 10.52711/0974-360X.2025.00368
Cite(Electronic):
Akmaljon D. Raximov, Mamurjon K. Pozilov, Nazokatxon X. Yakubova, Makhmud B. Gafurov, Kuralbay Zh. Rezhepov, Muzaffar I. Asrarov, Zafarjon M. Ernazarov. Effect of polyphenol YaN-1, a Diazoimino derivative of gossypol, on the membrane of Cardiac Mitochondria. Research Journal of Pharmacy and Technology. 2025;18(6):2575-1. doi: 10.52711/0974-360X.2025.00368 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-6-21
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