Author(s):
Rinita Amelia, Faridah Mohd Said, Farzana Yasmin, Sandeep Poddar, Harnavi Harun, Yusti Siana
Email(s):
rinitaamelia@gmail.com
DOI:
10.52711/0974-360X.2025.00366 
Address:
Rinita Amelia1*, Faridah Mohd Said2, Farzana Yasmin2, Sandeep Poddar2, Harnavi Harun3, Yusti Siana4
1Head Department of Histology, Faculty of Medicine, Baiturrahmah University 49HM+QCR, Jl. Bypass, Aie Pacah, Kec. Koto Tangah, Kota Padang, Sumatera Barat 25586, Indonesia.
2Lincoln University College, Wisma Lincoln, 12-18, Jalan SS 6/12, 47301 Petaling Jaya, Selangor, Malaysia.
3Faculty of Medicine, Andalas University, Limau Manis, Pauh, Padang City, West Sumatra 25175, Indonesia.
4Department of Nutrition, Medicine Faculty, Baiturrahmah University, 49HM+QCR, Jl. Bypass, Aie Pacah, Kec. Koto Tangah, Kota Padang, Sumatera Barat 25586, Indonesia.
*Corresponding Author
Published In:
Volume - 18,
Issue - 6,
Year - 2025
ABSTRACT:
Introduction: Diabetes Mellitus (DM) is a global health crisis. Probiotic meals consistently acted as antioxidants by preventing lipid peroxidation and retaining antioxidant enzyme activity, such as Superoxide Dismutase (SOD). To analyse the effect of Probiotic L. fermentum from dadiah sampled as novel antidiabetes through increased antioxidant Mn-SOD expression in DN rat model. Methods: This study is an experimental group designed with a post-test-only control group to analyse the effect of dadiah, LAB, and bacteriocin on alloxan-induced nephropathy diabetic rats. The groups are two control groups and five intervention groups for eight weeks. The production of the antioxidant manganese superoxide dismutase (Mn-SOD) was examined using Immunohistochemistry of kidney tissue and observe the level glucose blood serum. Results: According to the findings of the Kruskal-Wallis analysis, the p-value=0.014 (< 0.050). Thus, based on the results in blood glucose serum level by the Wallis scale test, the p-value=0.002 was obtained. Thus, it may be established that the average blood sugar levels vary significantly between treatments. Conclusion: Probiotics in dadiah has been shown to boost Mn-SOD expression and decrease hyperglycemia in the Nephropathy Diabetes rats model.
Cite this article:
Rinita Amelia, Faridah Mohd Said, Farzana Yasmin, Sandeep Poddar, Harnavi Harun, Yusti Siana. The Potency of Limosilactobacillus fermentum from Fermented Buffalo Milk (Dadiah) Sampled as Novel Antidiabetic Through Increased Superoxide Dismutase (SOD) Expression. Research Journal of Pharmacy and Technology. 2025;18(6):2561-6. doi: 10.52711/0974-360X.2025.00366
Cite(Electronic):
Rinita Amelia, Faridah Mohd Said, Farzana Yasmin, Sandeep Poddar, Harnavi Harun, Yusti Siana. The Potency of Limosilactobacillus fermentum from Fermented Buffalo Milk (Dadiah) Sampled as Novel Antidiabetic Through Increased Superoxide Dismutase (SOD) Expression. Research Journal of Pharmacy and Technology. 2025;18(6):2561-6. doi: 10.52711/0974-360X.2025.00366 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-6-19
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