Author(s):
Sarika Gupta, Dashrath Singh, Pravin Gupta
Email(s):
sarikagupta7017@gmail.com
DOI:
10.52711/0974-360X.2025.00362 
Address:
Sarika Gupta1*, Dashrath Singh2, Pravin Gupta3
1Department of Pharmacy, Institute of Biomedical Education and Research, Mangalayatan University, Aligarh-202146 India.
1Department of Pharmacy, Agra Public College of Higher Education and Research Centre, Agra-282007 India.
2Department of Pharmacy, Institute of Biomedical Education and Research, Mangalayatan University, Aligarh-202146 India.
3Shakuntala Devi College of Pharmacy, Kakyoli Nawabganj, Farrukhabad - 209501) India.
*Corresponding Author
Published In:
Volume - 18,
Issue - 6,
Year - 2025
ABSTRACT:
A simple, specific, accurate and precise method for estimating Venlafaxine Hcl has been developed and validated using literature data. The Stock solution was prepared by weighing 10mg of venlafaxine Hcl in 100ml volumetric flask with ethanol. The final Standard solution was made to produce 100µg/ml with ethanol. Some dilutions were prepared as per procedure and were scanned at 225nm. The linear graph was found in the 5-30µg /ml concentration range. The correlation coefficient and the regression equation was found to be 0.9976 and Y = 0.0166X+0.0012 respectively. Validation was performed on linearity, accuracy, precision, limit of detection, limit of quantitation, and ruggedness. The LOD and LOQ (limit of detection and limit of quantitation) for determination of venlafaxine Hcl was obtained as 0.607 (µg/ml) and 1.925 (µg/ml), respectively. The percentage recovery of Venlafaxine Hcl was estimated in the range of 98.6±0.003512-101.4±0.001. Venlafaxine in pharmaceutical dosage forms can be quantitatively determined using the proposed method.
Cite this article:
Sarika Gupta, Dashrath Singh, Pravin Gupta. Quantitative Analysis of Venlafaxine HCl via Spectroscopy: Method Development and Validation. Research Journal of Pharmacy and Technology. 2025;18(6):2533-6. doi: 10.52711/0974-360X.2025.00362
Cite(Electronic):
Sarika Gupta, Dashrath Singh, Pravin Gupta. Quantitative Analysis of Venlafaxine HCl via Spectroscopy: Method Development and Validation. Research Journal of Pharmacy and Technology. 2025;18(6):2533-6. doi: 10.52711/0974-360X.2025.00362 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-6-15
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