Author(s):
Chaitra D, Adiga Usha, Adiga Sachidananda, Divya N Pai
Email(s):
chaitrad@nitte.edu.in , Ushachidu@yahoo.com , adigaiscool@yahoo.com
DOI:
10.52711/0974-360X.2025.00361 
Address:
Chaitra D1, Adiga Usha2*, Adiga Sachidananda3, Divya N Pai4
1Assistant Professor, Department of Anatomy, K S Hegde Medical Academy, Mangalore, Karnataka India.
2Professor, Department of Biochemistry, Apollo Institute of Medical Sciences and Research, Chittoor, India.
3Professor, Department of Pharmacology, Apollo Institute of Medical Sciences and Research, Chittoor India.
4Assistant Professor, Department of Anatomy, K S Hegde Medical Academy, Mangalore Karnataka India.
*Corresponding Author
Published In:
Volume - 18,
Issue - 6,
Year - 2025
ABSTRACT:
Diabetic foot, a serious complication of diabetes mellitus, involves delayed wound healing and an increased risk of infection and amputation. Netrin-1, a laminin-related secreted protein, plays a key role in angiogenesis, inflammation, and tissue repair, making it a relevant gene in diabetic foot pathology. This study aimed to identify and analyse single nucleotide polymorphisms (SNPs) in the Netrin-1 (NTN1) gene using bioinformatics tools to distinguish between damaging and neutral variants. Predictive algorithms such as SIFT, PROVEAN, and I- Tasser were used to assess their potential impact. Notably, SNP analysis at position 223 revealed several potentially harmful substitutions. Structural modelling indicated that these mutations could alter the protein’s size and charge, potentially disrupting its normal function.
Cite this article:
Chaitra D, Adiga Usha, Adiga Sachidananda, Divya N Pai. Analysis of Netrin 1 Gene using Bioinformatics in patients with Diabetic Foot. Research Journal of Pharmacy and Technology. 2025;18(6):2528-2. doi: 10.52711/0974-360X.2025.00361
Cite(Electronic):
Chaitra D, Adiga Usha, Adiga Sachidananda, Divya N Pai. Analysis of Netrin 1 Gene using Bioinformatics in patients with Diabetic Foot. Research Journal of Pharmacy and Technology. 2025;18(6):2528-2. doi: 10.52711/0974-360X.2025.00361 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-6-14
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