In Vivo Efficacy of Curcumin-Encapsulated Polymeric Nanocarriers Enriched Nanogel for Accelerated Burn Wound Recovery

Homesh Yadav; Anand Mahalvar

doi:10.52711/0974-360X.2025.00332

Research Journal of Pharmacy and Technology

ISSN

0974-360X (Online)
0974-3618 (Print)

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In Vivo Efficacy of Curcumin-Encapsulated Polymeric Nanocarriers Enriched Nanogel for Accelerated Burn Wound Recovery

Author(s): Homesh Yadav, Anand Mahalvar

Email(s): mahalwaranand@gmail.com

DOI: 10.52711/0974-360X.2025.00332

Address: Homesh Yadav, Anand Mahalvar*
ISBM University, Nawapara, Gariyaband, Chhattisgarh, 493996, India.
*Corresponding Author

Published In: Volume - 18, Issue - 5, Year - 2025

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ABSTRACT:
Burn injuries remain a major global health concern, leading to long-term complications, including scarring, infections, and delayed healing. The current study investigates the in vivo efficacy of curcumin-loaded polymeric nanoparticles (CuR-PNPs) for enhancing the healing process in burn wounds. Curcumin, a natural compound with well-documented antioxidant, anti-inflammatory, and antimicrobial properties, was encapsulated in polymeric nanoparticles to improve its bioavailability and therapeutic potential. In vivo studies were conducted on male Wistar albino rats with second-degree burn wounds, comparing the wound healing outcomes of CuR-PNPs gel, plain CuR-gel, and a marketed formulation (Burn Eaz gel). Results demonstrated that CuR-PNPs significantly accelerated wound contraction and reduced epithelization time compared to the other formulations. Furthermore, the CuR-PNPs gel exhibited minimal skin irritation and improved drug retention in the epidermis and dermis, promoting sustained curcumin release at the wound site. These findings suggest that polymeric nanoparticles offer a promising strategy for enhancing the therapeutic efficacy of curcumin in burn wound management.

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Cite this article:
Homesh Yadav, Anand Mahalvar. In Vivo Efficacy of Curcumin-Encapsulated Polymeric Nanocarriers Enriched Nanogel for Accelerated Burn Wound Recovery. Research Journal of Pharmacy and Technology. 2025;18(5):2321-8. doi: 10.52711/0974-360X.2025.00332

Cite(Electronic):
Homesh Yadav, Anand Mahalvar. In Vivo Efficacy of Curcumin-Encapsulated Polymeric Nanocarriers Enriched Nanogel for Accelerated Burn Wound Recovery. Research Journal of Pharmacy and Technology. 2025;18(5):2321-8. doi: 10.52711/0974-360X.2025.00332 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-5-55

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