Author(s):
Nur Wahyuniati, Agnes Rengga Indrati, Dzulfikar DLH, Coriejati Rita, Cissy B. Kartasasmita, Dwi Agustian, Nur Atik
Email(s):
agnes.indrati@unpad.ac.id
DOI:
10.52711/0974-360X.2025.00327 
Address:
Nur Wahyuniati1,2, Agnes Rengga Indrati3*, Dzulfikar DLH4, Coriejati Rita3, Cissy B. Kartasasmita4, Dwi Agustian5, Nur Atik6
1Doctoral Study Program, Faculty of Medicine, Universitas Padjadjaran, Bandung 40161, Indonesia.
2Department of Parasitology, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia.
3Department of Clinical Pathology, Faculty of Medicine, Universitas Padjadjaran, Dr. Hasan Sadikin General Hospital, Bandung 40161, Indonesia.
4Department of Child Health, Faculty of Medicine, Universitas Padjadjaran, Dr. Hasan Sadikin General Hospital, Bandung 40161, Indonesia.
5Department of Epidemiology and Biostatistics, Faculty of Medicine, Universitas Padjadjaran, Bandung 40161, Indonesia.
6Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung 40161, Indonesia.
*Corresponding Author
Published In:
Volume - 18,
Issue - 5,
Year - 2025
ABSTRACT:
The elderly population is at high risk of severe complications from influenza due to decreased effectiveness of the immune response (Immunosenescence). Trivalent influenza vaccines are designed to boost immunity and provide protection against some influenza virus strains. The research aims to evaluate the effectiveness of the trivalent influenza vaccine in enhancing immune response in elderly populations by examining specific immunological parameters. A total of 44 elderly participants were vaccinated with one of three trivalent influenza vaccines: A/Singapore – EFTHA 1835, A/Singapore – EFTHAS 1828, and B/Maryland – EFTTHAC 1822. Antibody titers were measured using the Hemagglutination Inhibition (HAI) test before and after vaccination. Levels of immunological markers IL-15, MIP-1a, IFN-?, and CD16 were assessed using an enzyme-linked immunosorbent assay (ELISA). Before immunization, HAI titers were low in all groups. After vaccination, all groups showed a significant increase in HAI titers (p = 0.000), with the largest increase in group A/Singapore – EFTHA 1835. IL-15 and MIP-1a levels increased, while IFN-? (p = 0.003) and CD16 levels decreased significantly. The trivalent influenza vaccine effectively enhances the immune response in the elderly population, evidenced by increased HAI titers and significant changes in immunological markers.
Cite this article:
Nur Wahyuniati, Agnes Rengga Indrati, Dzulfikar DLH, Coriejati Rita, Cissy B. Kartasasmita, Dwi Agustian, Nur Atik. Efficacy of Trivalent Influenza Vaccine in Enhancing Boosting Immunity among the Elderly Population: A Study of Immunologic Parameter. Research Journal of Pharmacy and Technology. 2025;18(5):2281-0. doi: 10.52711/0974-360X.2025.00327
Cite(Electronic):
Nur Wahyuniati, Agnes Rengga Indrati, Dzulfikar DLH, Coriejati Rita, Cissy B. Kartasasmita, Dwi Agustian, Nur Atik. Efficacy of Trivalent Influenza Vaccine in Enhancing Boosting Immunity among the Elderly Population: A Study of Immunologic Parameter. Research Journal of Pharmacy and Technology. 2025;18(5):2281-0. doi: 10.52711/0974-360X.2025.00327 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-5-50
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