Author(s):
Anshu kadiyan, Parbhjeet Kaur Bamrah, Amit Lather, Amandeep Dhull, Ramchander Khatri, Sandeep kumar, Tanuj Hooda
Email(s):
prabhjeet.ips@kuk.ac.in
DOI:
10.52711/0974-360X.2025.00318 
Address:
Anshu kadiyan1, Parbhjeet Kaur Bamrah1, Amit Lather2, Amandeep Dhull2, Ramchander Khatri3, Sandeep kumar4, Tanuj Hooda4*
1Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra-136119, India.
2Geeta Institute of Pharmacy, Geeta University, Naultha, Panipat-132145, India.
3Delhi Pharmaceutical Sciences and Research University, New Delhi, Delhi-110017, India.
4MM College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullan, Ambala-133207, India.
*Corresponding Author
Published In:
Volume - 18,
Issue - 5,
Year - 2025
ABSTRACT:
Introduction: Peptic ulcer is a disease of GIT that results ofchronically inequityof endogenous gastro protective factors and destructive factors. The primary cause of the erosion of mucosal layer may befactors like smoking, poor diet, excessive intake of alcohol, NSAIDs and H. pylori infection. Phytochemical screening of Citrus Limetta Risso confirms the presence of alkaloids, glycosides, saponins, flavonoids, anthraquinones, phenolics, tannins, and terpenes. According to literature cited by various authors alkaloids, flavonoids, and D-limonene present in Citrus Limetta Risso have the potential for antiulcer activity. Methods: Present study aimed at investigating the gastro protective effects of Citrus limetta against ethanol-induced gastric ulcers in mice using famotidine as a control drug. Ethanol induced gastric ulcer model in mice was used for evaluation; ulcer index was calculated by scoring the ulcers. Biochemical estimation of stomach tissues were completed by SOD, GSH, LPO, catalase methods. Results: The results of findings demonstrated that the mice group pre-treated with C. limetta juice significantly lower the GUI and raised the ulcer inhibition rate of gastric ulcers. Conclusion: Mechanism behind the C. limetta juice may be neutralization reactionwith gastric acid, further studies required so that it could be used as alternate to currently used antiulcer drugs.
Cite this article:
Anshu kadiyan, Parbhjeet Kaur Bamrah, Amit Lather, Amandeep Dhull, Ramchander Khatri, Sandeep kumar, Tanuj Hooda. Gastro protective potential of Citrus limetta Risso fruit juice in Ethanol induced gastric ulcer Mice model. Research Journal of Pharmacy and Technology. 2025;18(5):2220-6. doi: 10.52711/0974-360X.2025.00318
Cite(Electronic):
Anshu kadiyan, Parbhjeet Kaur Bamrah, Amit Lather, Amandeep Dhull, Ramchander Khatri, Sandeep kumar, Tanuj Hooda. Gastro protective potential of Citrus limetta Risso fruit juice in Ethanol induced gastric ulcer Mice model. Research Journal of Pharmacy and Technology. 2025;18(5):2220-6. doi: 10.52711/0974-360X.2025.00318 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-5-41
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