Author(s):
Sudhina Makuttan, Jennifer Fernandes, Meenaxi M Maste, Nishmitha Gretta Dsouza
Email(s):
fernandesj@nitte.edu.in
DOI:
10.52711/0974-360X.2025.00298 
Address:
Sudhina Makuttan1, Jennifer Fernandes2*, Meenaxi M Maste3, Nishmitha Gretta Dsouza1
1Department of Pharmaceutical Chemistry, Father Muller College of Pharmaceutical Sciences, (A Unit of Father Muller Charitable Institutions), University Road, Deralakatte, Mangaluru - 575 018, Karnataka, India.
2Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be University), Mangaluru- 575018, Karnataka, India.
3Department of Pharmaceutical Chemistry, KLE College of Pharmacy, KLE Academy of Higher Education & Research, Belgaum - 575018, Karnataka, India.
*Corresponding Author
Published In:
Volume - 18,
Issue - 5,
Year - 2025
ABSTRACT:
Plants have been used extensively as medicine for centuries to treat a variety of ailments. The current work aimed to screen for the existence of bioactive ingredients using GC-MS and to test the anti-inflammatory effectiveness of ethanolic and aqueous fruit extracts of the Flacourtia indica plant. The GC-MS analysis revealed a total of 24 Phytoconstituents in the ethanolic extracts and 6 compounds in the aqueous extracts of the Flacourtia indica plant. The results of the GC-MS analysis indicated that the bioactive components found in the fruit extracts are biologically active. Among the compounds identified N-Hexadecanoic acid was the most abundant anti-inflammatory agent (18.032%) present in the ethanolic extract of Flacourtia indica fruit. Hence the invitro anti-inflammatory activity of fruit extracts were determined by protein denaturation and HRBC membrane stabilization methods. The anti-inflammatory test yielded promising findings, with high levels of inhibition by ethanolic extracts, including 64.23% in HRBC membrane stabilization and 70% in protein denaturation procedures.
Cite this article:
Sudhina Makuttan, Jennifer Fernandes, Meenaxi M Maste, Nishmitha Gretta Dsouza. GC-MS Characterization and in vitro Anti-Inflammatory Activity of Fruit Extracts of Flacourtia indica (Burm.F.) Merr. Research Journal of Pharmacy and Technology. 2025;18(5):2081-9. doi: 10.52711/0974-360X.2025.00298
Cite(Electronic):
Sudhina Makuttan, Jennifer Fernandes, Meenaxi M Maste, Nishmitha Gretta Dsouza. GC-MS Characterization and in vitro Anti-Inflammatory Activity of Fruit Extracts of Flacourtia indica (Burm.F.) Merr. Research Journal of Pharmacy and Technology. 2025;18(5):2081-9. doi: 10.52711/0974-360X.2025.00298 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-5-21
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