Author(s):
Fenita Shoviantari, Tristiana Erawati Munandar, Widji Soeratri, Mahardian Rahmadi, Inayah Dian Wulandari
Email(s):
tristiana-e-m@ff.unair.ac.id
DOI:
10.52711/0974-360X.2025.00292 
Address:
Fenita Shoviantari1,4, Tristiana Erawati Munandar2,3*, Widji Soeratri2,3, Mahardian Rahmadi2,3, Inayah Dian Wulandari4
1Doctoral Program of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Gedung Nanizar Zaman Joenoes Kampus C UNAIR Jalan Mulyorejo Surabaya, East Java, Indonesia, 60115.
2Department of Pharmaceutical Science, Faculty of Pharmacy, Universitas Airlangga, Gedung Nanizar Zaman Joenoes Kampus C UNAIR Jalan Mulyorejo Surabaya, East Java, Indonesia, 60115.
3Skin and Cosmetic Technology (SCT) Center of Excellent, Universitas Airlangga, Gedung Nanizar Zaman Joenoes Kampus C UNAIR Jalan Mulyorejo Surabaya, East Java, Indonesia, 60115.
4Faculty of Pharmacy, Institut Ilmu Kesehatan Bhakti Wiyata, Jalan KH Wahid Hasyim 65 Kediri, East Java, Indonesia, 64117.
*Corresponding Author
Published In:
Volume - 18,
Issue - 5,
Year - 2025
ABSTRACT:
Butterfly pea (Clitoria ternatea) is a plant that has been widely studied as an antioxidant. Antioxidants are compounds that are believed to have various activities, one of which is that they can be used as whitening agents on the skin. The antioxidant ability of water extract of butterfly pea flower is thought to come from the anthocyanin component in the flowers. The objective of this research is to determine the inhibitory activity of the enzyme tyrosinase from 5 of the most abundant anthocyanins in water extracts of butterfly pea flowers. The method of this study, docking of test compounds against target receptors, was carried out using the Autodock Tools and Autodock 4.2 programs. From the results of molecular Docking, it was found that the five most abundant anthocyanins from butterfly pea flowers were Cyanidin 3-(p-coumaroyl)-glucoside, Cyanidin-3-(p-coumaroyl)-rutinoside-5-glucoside, Delphinidin-3-O-(6- p- coumaroyl)glucoside, Delphinidin-3-(p-coumaroyl)-rutinoside-5-glucoside, and Delphinidin 3-O-glucoside have the same activity as hydroquinone as anti-melanogenesis when viewed from the ?G, Ki, and residue similarity values amino acids that interact with the ligand. However, Delphinidin-3-O-(6-p-coumaroyl) glucoside has the lowest ?G value of -9.23 kcal/mol with a Ki of 170.82nM compared to hydroquinone and other test compounds.
Cite this article:
Fenita Shoviantari, Tristiana Erawati Munandar, Widji Soeratri, Mahardian Rahmadi, Inayah Dian Wulandari. Molecular Docking Anti Melanogenesis Activity of Anthocyanins from Butterfly Pea (Clitoria ternatea) Flower Water Extract. Research Journal of Pharmacy and Technology. 2025;18(5):2043-8. doi: 10.52711/0974-360X.2025.00292
Cite(Electronic):
Fenita Shoviantari, Tristiana Erawati Munandar, Widji Soeratri, Mahardian Rahmadi, Inayah Dian Wulandari. Molecular Docking Anti Melanogenesis Activity of Anthocyanins from Butterfly Pea (Clitoria ternatea) Flower Water Extract. Research Journal of Pharmacy and Technology. 2025;18(5):2043-8. doi: 10.52711/0974-360X.2025.00292 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-5-15
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