Author(s):
Muthia Fadhila, Indra Makmur, Indah Apri Delpita
Email(s):
muthiafadhila@stifarm-padang.ac.id
DOI:
10.52711/0974-360X.2025.00262 
Address:
Muthia Fadhila*, Indra Makmur, Indah Apri Delpita
Department of Pharmaceutics, School of Pharmaceutical Science, Padang (STIFARM Padang), West Sumatera, Indonesia, 25147.
*Corresponding Author
Published In:
Volume - 18,
Issue - 4,
Year - 2025
ABSTRACT:
Gemfibrozil is a substance that lowers serum triglyceride, total cholesterol, and VLDL cholesterol, which helps to manage blood fat levels. Gemfibrozil is a member of class II of the Biopharmaceutical Classification System (BCS), which includes medications with poor solubility but strong membrane permeability. Determining the physicochemical characteristics, enhanced solubility, and rate of dissolution of gemfibrozil-succinic acid was the goal of this study. In this study, a physical combination was prepared for comparison and a multicomponent crystal was created utilizing the solvent drop grinding process at a ratio of 1:1 mole. Solubility tests, dissolution tests, and physicochemical qualities were all included in the multifaceted assessment of crystal and physical combinations. Using the Differential Scanning Calorimeter (DSC), Fourier Transform Infrared (FT-IR), and X-Ray Diffraction (XRD), the physicochemical parameters of the samples were evaluated. Phosphate buffer pH 7.5 is used for the dissolving test and CO2-free distilled water is used for the solubility test. When compared to pure gemfibrozil, the multicomponent crystal solubility test results rose 25 times. The multicomponent crystal dissolution test demonstrated a rise, with a dissolution percentage of 46.13% at 60 minutes—higher than the gemfibrozil dissolution percentage of 25.99%.
Cite this article:
Muthia Fadhila, Indra Makmur, Indah Apri Delpita. Improving Dissolution Rate of Gemfibrozil by Multicomponent Crystal Formation with Succinic Acid. Research Journal of Pharmacy and Technology. 2025;18(4):1831-6. doi: 10.52711/0974-360X.2025.00262
Cite(Electronic):
Muthia Fadhila, Indra Makmur, Indah Apri Delpita. Improving Dissolution Rate of Gemfibrozil by Multicomponent Crystal Formation with Succinic Acid. Research Journal of Pharmacy and Technology. 2025;18(4):1831-6. doi: 10.52711/0974-360X.2025.00262 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-4-53
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