Author(s):
Idham Jaya Ganda, Urfianty, Hadia Angriani, Rinvil Renaldi, Nadirah Rasyid Ridha Pujihastuti, Sherly Sumartiya, Khadijah A. Mansur, Vawella Febria, Ansar, Asty Almaida, Muhammad Nasrum Massi
Email(s):
dhamjaya_spa@yahoo.co.id
DOI:
10.52711/0974-360X.2025.00259 
Address:
Idham Jaya Ganda1,2*, Urfianty1,2, Hadia Angriani2,3, Rinvil Renaldi3, Nadirah Rasyid Ridha1,2 Pujihastuti4, Sherly Sumartiya4, Khadijah A. Mansur4, Vawella Febria4, Ansar5, Asty Almaida6, Muhammad Nasrum Massi7
1Department of Pediatrics, Faculty of Medicine Hasanuddin University, Makassar, 90245, Indonesia.
2Child Health Department, DR Wahiddin Sudirohusodo Hospital, Makassar, 90245, Indonesia.
3Department of Child and Adolescent Psychiatry, Faculty of Medicine, Hasanuddin University, Makassar, 90245, Indonesia.
4Pediatrics Study Program, Faculty of Medicine Hasanuddin University, Makassar, 90245, Indonesia.
5Communication Faculty of Pejuang Republik Indonesia University, Makassar, 90234, Indonesia.
6Management Department, Faculty of Economics and Bussiness, Hasanuddin University, Makassar, 90245, Indonesia.
7Department of Microbiology, Faculty of Medicine Hasanuddin University, Makassar, 90245, Indonesia.
*Corresponding Author
Published In:
Volume - 18,
Issue - 4,
Year - 2025
ABSTRACT:
Objective: This study assessed cognitive impairment using the school-year screening test of mental status-revised (SYSTEMS-R) and intelligence quotient (IQ) level using Raven Progressive Matrices in children with acute lymphoblastic leukemia (ALL) who received chemotherapy. Materials and Methods: This cross-sectional study was conducted at the Mother and Child Outpatient Clinic and the child psychiatric outpatient clinic from April to July 2023. The population was ALL patients collected by consecutive sampling with a total of 150 subjects. Results: The prevalence of cognitive impairment was 24.7%, and the low IQ level was 24.7%. There was a correlation between cognitive impairment and the chemotherapy phase, with the frequency in each phase being 10.4%, 23.4%, and 38.2%. There was a relationship between low IQ level and chemotherapy phase, with the frequency at each phase being 12.5%, 21.3%, and 38.2%. There was a significant relationship between cognitive impairment and low IQ level, with an OR of 5.017 (95% CI 2.892 - 8.705). ALL chemotherapy patients with cognitive impairment had an 83.3% chance of having a low IQ. Conclusion: There was a correlation between the chemotherapy phase, cognitive impairment, and low IQ level. ALL chemotherapy patients are more likely to have a low IQ level.
Cite this article:
Idham Jaya Ganda, Urfianty, Hadia Angriani, Rinvil Renaldi, Nadirah Rasyid Ridha Pujihastuti, Sherly Sumartiya, Khadijah A. Mansur, Vawella Febria, Ansar, Asty Almaida, Muhammad Nasrum Massi. Cognitive Impairment in children with Acute Lymphoblastic Leukemia and its relationship with Chemotherapy. Research Journal of Pharmacy and Technology. 2025;18(4):1809-4. doi: 10.52711/0974-360X.2025.00259
Cite(Electronic):
Idham Jaya Ganda, Urfianty, Hadia Angriani, Rinvil Renaldi, Nadirah Rasyid Ridha Pujihastuti, Sherly Sumartiya, Khadijah A. Mansur, Vawella Febria, Ansar, Asty Almaida, Muhammad Nasrum Massi. Cognitive Impairment in children with Acute Lymphoblastic Leukemia and its relationship with Chemotherapy. Research Journal of Pharmacy and Technology. 2025;18(4):1809-4. doi: 10.52711/0974-360X.2025.00259 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-4-50
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