Author(s):
Eka Fitria Augustina, Noer Ulfah, Arina Farmalabitta Annis, Nur Riflianty Rivai
Email(s):
eka-f-a@fkg.unair.ac.id
DOI:
10.52711/0974-360X.2025.00243 
Address:
Eka Fitria Augustina1, Noer Ulfah1, Arina Farmalabitta Annis2, Nur Riflianty Rivai2
1Department of Periodontology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
2Student of Periodontics Residential Program, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
*Corresponding Author
Published In:
Volume - 18,
Issue - 4,
Year - 2025
ABSTRACT:
Introduction: Porphyromonas gingivalis is gram-negative oral anaerobe that is involved in the pathogenesis of periodontitis, that can locally invade periodontal tissues and evade the host defense mechanisms. P. gingivalis activates NF-?B in gingival epithelial tissue and increases the synthesis of inflammatory cytokines like IL-6. Water hyacinth (Eichornia crassipes) possess some pharmacological activities including anti-inflammatory and is reported to be natural alternative therapeutic. Aim: This study was planned to evaluate the potential of extracting Eichornia crassipes 2% in reducing the expression of IL-6. Methods: Thirty-five wistar rats were assigned into 7 groups ; normal, control, and treatment groups, which 5 wistar rats for each group. The control groups were performed by 0.03 ml of P. gingivalis 2x106 CFU which was dropped into the anterior mandible of the gingival sulcus of Wistar rats every 48 hours for 7 days. The treatment groups were performed same bacteria as the control group and 2% of Eichornia crassipes extract. The tissue samples were evaluated by immunohistochemical staining. Result: The expression levels of IL-6 showed a significant decrease in the treatment groups (sig<0,005). This means that there was a significant decrease in IL-6 expression on all treatment groups compared to control groups. Conclusion: The administration of Eichornia crassipes in wistar rats induction decreased IL-6 expression .
Cite this article:
Eka Fitria Augustina, Noer Ulfah, Arina Farmalabitta Annis, Nur Riflianty Rivai. The Expression of IL-6 in Gingival Wistar Rats Induced by Porphyromonas gingivalis with Water Hyacinth (Eichornia crassipes) Extract 2%. Research Journal of Pharmacy and Technology. 2025;18(4):1696-1. doi: 10.52711/0974-360X.2025.00243
Cite(Electronic):
Eka Fitria Augustina, Noer Ulfah, Arina Farmalabitta Annis, Nur Riflianty Rivai. The Expression of IL-6 in Gingival Wistar Rats Induced by Porphyromonas gingivalis with Water Hyacinth (Eichornia crassipes) Extract 2%. Research Journal of Pharmacy and Technology. 2025;18(4):1696-1. doi: 10.52711/0974-360X.2025.00243 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-4-34
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