Author(s):
Shahed Kuraitby, Mays Khazem, Abeer A. Aljoujou
Email(s):
shahed.y1997@gmail.com
DOI:
10.52711/0974-360X.2025.00238 
Address:
Shahed Kuraitby1*, Mays Khazem2, Abeer A. Aljoujou3
1Department of Oral Medicine, Faculty of Dental Medicine, University of Damascus, Damascus, Syria.
2Department of Pharmacognosy, Faculty of Pharmacy, University of Damascus, Damascus, Syria.
3Department of Oral Medicine, Faculty of Dental Medicine, University of Damascus, Damascus, Syria.
*Corresponding Author
Published In:
Volume - 18,
Issue - 4,
Year - 2025
ABSTRACT:
Aims: To investigate the efficacy of Curcumin suspension (CUR) in managing candida-associated denture stomatitis (CADS) through clinical and laboratory evaluations. Materials and Methods: A randomized controlled trial was conducted on 30 patients diagnosed with Denture stomatitis (DS). Patients were randomly assigned to two groups (n=15 each): a Curcumin suspension group (0.1% concentration, three times daily, for 14 days) and a control group receiving nystatin (100000 IU, four times daily, for 14 days). Inflammatory index and the count of Candida were measured before and after treatment (24 hours after the last dose). Results: The current study showed decreased inflammation index values in both research groups. There was a statistically significant difference in the inflammation index related to the area affected before and after treatment, with p-values of 0.034 and 0.001 for the nystatin and curcumin groups, respectively. Additionally, there was a statistically significant difference in the inflammation index related to the severity of the inflammation, with p-values of 0.011 and 0.002 for the nystatin and curcumin groups, respectively. When comparing the differences in indices between the two groups, the results indicated that curcumin outperformed nystatin in both the area and severity of inflammation indices, with p-values of 0.001 and 0.005, respectively. Both groups showed a decrease in the counts of candida colonies, but there were no statistically significant differences in fungal diagnosis between the two groups, with a p-value of 0.054. Discussion: Curcumin is an alternative effective treatment in managing the severity and area of the prevalence of DS inflammation through its antifungal as well as anti-inflammatory effects and relieving the development of fungal resistance. Trial registration: the trial was registered in a public clinical trials database (Trial registration isrctn.com ID: ISRCTN 15898291).
Cite this article:
Shahed Kuraitby, Mays Khazem, Abeer A. Aljoujou. The Antifungal and Anti-inflammatory effects of Curcumin on Candida-associated Denture Stomatitis: A Clinical and Laboratory Study. Research Journal of Pharmacy and Technology. 2025;18(4):1663-9. doi: 10.52711/0974-360X.2025.00238
Cite(Electronic):
Shahed Kuraitby, Mays Khazem, Abeer A. Aljoujou. The Antifungal and Anti-inflammatory effects of Curcumin on Candida-associated Denture Stomatitis: A Clinical and Laboratory Study. Research Journal of Pharmacy and Technology. 2025;18(4):1663-9. doi: 10.52711/0974-360X.2025.00238 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-4-29
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