Author(s):
Mariadi, Bayu Eko Prasetyo, Emil Salim, Aranova Esovin Patricia Butar Butar, Shafiyya Amali, Johanna Fransiska Lambue Siahaan, Rinny Argasari Sitanggang
Email(s):
bayu@usu.ac.id
DOI:
10.52711/0974-360X.2025.00211 
Address:
Mariadi1,4, Bayu Eko Prasetyo1,4*, Emil Salim2, Aranova Esovin Patricia Butar Butar3, Shafiyya Amali3, Johanna Fransiska Lambue Siahaan3, Rinny Argasari Sitanggang3
1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Sumatera Utara, 20155, Indonesia.
2Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, 20155, Indonesia.
3Undergraduate Program, Faculty of Pharmacy, Universitas Sumatera Utara, 20155, Indonesia.
4Nanomedicine Centre of Innovation, Universitas Sumatera Utara, 20155, Indonesia.
*Corresponding Author
Published In:
Volume - 18,
Issue - 4,
Year - 2025
ABSTRACT:
Bad breath is a health issue characterized by unpleasant breath originating from the oral cavity, often caused by bacterial growth. One significant contributor to bad breath is the proliferation of bacteria responsible for dental caries, namely Streptococcus mutans (S. mutans). Lemongrass (Cymbopogon citratus (DC). Stapf), known for the antibacterial properties, has long been used as a traditional remedy for treating bad breath. Therefore, this study aimed to develop Oral Thin Film (OTF) preparation containing lemongrass extract as one of the solutions to reduce bad breath. Lemongrass leaves were extracted using 96% ethanol through maceration. OTF preparation optimization was carried out by solvent casting method using 3% gelatin and variations of Hydroxy Propyl Methyl Cellulose (HPMC) and corn starch in 5 formulas (F1-F5), namely 1:0, 3:1, 1:1, 1:3, and 0:1, respectively. The evaluation criteria for the OTF included organoleptic test, weight uniformity, film thickness, pH, folding resistance, color assesment, disintegration time and antibacterial efficacy against S. mutans using the disc diffusion method. Stability tests were conducted at different temperatures (25oC and 40oC) over a period of 3 months. The OTF preparation had a uniform film weight, film thickness in the range of 0.2240 - 0.3415mm, pH value at 6.12-6.36, folding resistance at 339.67 - 579.50 times, and disintegration time at 60-105 s. Despite exhibiting good stability over a 3-month period, all films demonstrated weak antibacterial activity, as shown by inhibition zone diameters ranging from 7.8 to 8.7mm. The preparation of OTF loaded with Cymbopogon citratus leaf ethanolic extract yielded excellent physical characteristics.
Cite this article:
Mariadi, Bayu Eko Prasetyo, Emil Salim, Aranova Esovin Patricia Butar Butar, Shafiyya Amali, Johanna Fransiska Lambue Siahaan, Rinny Argasari Sitanggang. Fabrication and Evaluation of Oral Thin Film containing Cymbopogon citratus (DC). Stapf. Extract Based on Gelatine, Hydroxy Propyl Methyl Cellulose and Corn Starch Combination. Research Journal of Pharmacy and Technology. 2025;18(4):1474-0. doi: 10.52711/0974-360X.2025.00211
Cite(Electronic):
Mariadi, Bayu Eko Prasetyo, Emil Salim, Aranova Esovin Patricia Butar Butar, Shafiyya Amali, Johanna Fransiska Lambue Siahaan, Rinny Argasari Sitanggang. Fabrication and Evaluation of Oral Thin Film containing Cymbopogon citratus (DC). Stapf. Extract Based on Gelatine, Hydroxy Propyl Methyl Cellulose and Corn Starch Combination. Research Journal of Pharmacy and Technology. 2025;18(4):1474-0. doi: 10.52711/0974-360X.2025.00211 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-4-2
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