Author(s):
Manikya Pramudya, Hari Soepriandono, Farah Annisa Nurbani, Maya Safitri, Firli Rahmah Primula Dewi, Arghi Kinanthya Rif’atullah Al Hanif, Raden Joko Kuncoroningrat Susilo, Aunurohim, Bayyinatul Muchtaromah, Alfiah Hayati
Email(s):
alfiah-h@fst.unair.ac.id
DOI:
10.52711/0974-360X.2025.00225 
Address:
Manikya Pramudya1, Hari Soepriandono1, Farah Annisa Nurbani1, Maya Safitri1, Firli Rahmah Primula Dewi1, Arghi Kinanthya Rif’atullah Al Hanif1, Raden Joko Kuncoroningrat Susilo2, Aunurohim3, Bayyinatul Muchtaromah4, Alfiah Hayati1*
1Department of Biology, Faculty of Science and Technology, Universitas Airlangga, Indonesia.
2Department of Engineering, Faculty of Science and Tecnology, Universitas Airlangga, Indonesia.
3Department of Biology, Faculty Science and Data Analitics, Sepuluh Nopember Institute of Technology, Indonesia.
4Department of Biology, Faculty of Science and Technology, Maulana Malik Ibrahim Malang Islamic State University, Indonesia.
*Corresponding Author
Published In:
Volume - 18,
Issue - 4,
Year - 2025
ABSTRACT:
The growth of the plastic industry alongside inadequate management of plastic waste has resulted in plastic pollution. Nanoplastic particles can be toxic and induce oxidative stress. This research explored the ability of Cinnamomum burmanii leaf extract to mitigate hematological alterations induced by exposure to low-dose nanoplastics polystyrene (NPs) in male albino rats. Normal control and negative control groups were administrated with aquadest and NPs solution (10µL/kg) for 14 days respectively, followed by aquadest for the next 21 days. Groups 3, 4, and 5 received a combined treatment of NPs for 14 days and extract for 21 days (100, 200, and 400mg/kg). Each group consists of five rats. Animal treatments were administered through oral gavage. Then, the hematological parameters were analyzed. The results revealed that exposure to NPs caused a significant elevation in lymphocyte counts and a decrease in monocytes, red blood cells (RBC), hemoglobin (Hb), and hematocrit (Ct). Nevertheless, there was no significant impact observed on white blood cells (WBC), granulocytes, or platelet counts. Within the groups treated with Cinnamomum burmanii leaf extract, a reduction in lymphocyte and WBC counts was observed, alongside an increase in monocyte counts. However, there was no significant increase noted in red RBC, Hb, Ct, or platelet counts. Cinnamomum burmanii leaf extract may hold promise in improving the hemodynamic profile in bodies exposed to NPs.
Cite this article:
Manikya Pramudya, Hari Soepriandono, Farah Annisa Nurbani, Maya Safitri, Firli Rahmah Primula Dewi, Arghi Kinanthya Rif’atullah Al Hanif, Raden Joko Kuncoroningrat Susilo, Aunurohim, Bayyinatul Muchtaromah, Alfiah Hayati. Cinnamomum burmanii Leaf Extract Potential on Hematological Assessment of Rats Exposed to Polystyrene Nanoplastics. Research Journal of Pharmacy and Technology. 2025;18(4):1573-8. doi: 10.52711/0974-360X.2025.00225
Cite(Electronic):
Manikya Pramudya, Hari Soepriandono, Farah Annisa Nurbani, Maya Safitri, Firli Rahmah Primula Dewi, Arghi Kinanthya Rif’atullah Al Hanif, Raden Joko Kuncoroningrat Susilo, Aunurohim, Bayyinatul Muchtaromah, Alfiah Hayati. Cinnamomum burmanii Leaf Extract Potential on Hematological Assessment of Rats Exposed to Polystyrene Nanoplastics. Research Journal of Pharmacy and Technology. 2025;18(4):1573-8. doi: 10.52711/0974-360X.2025.00225 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-4-16
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