Author(s):
Rani Bhandarkavathe, Hugar Shivakumar, Nanjappaiah H. M., Virupanagouda P. Patil, Maharani Bhandarkavathe
Email(s):
ranihb98@gmail.com
DOI:
10.52711/0974-360X.2025.00224 
Address:
Rani Bhandarkavathe, Hugar Shivakumar, Nanjappaiah H. M., Virupanagouda P. Patil*, Maharani Bhandarkavathe
Department of Pharmacology, BLDEA's Shri Sanganabasava Mahaswamiji College of Pharmacy and Research Centre, Smt Bangaramma Sajjan Campus, B.M.Patil Road, Vijayapura-586103.
*Corresponding Author
Published In:
Volume - 18,
Issue - 4,
Year - 2025
ABSTRACT:
Neurodegeneration, or the degeneration of neurons, is one of the main causes of neurological diseases. Because adenosine A2a receptor antagonists have neuroprotective properties, they were studied in a haloperidol animal model of Parkinson's disease. This study was designed to evaluate the Anti-parkinsonism activity of Psidium guajava leaves ethanolic extract in experimental animals. The ethanolic extract of Psidium guajava leaves was screened for anti-parkinsonism activity against haloperidol induced Parkinsonism models. The various relevant behavioural activity and biochemical parameters like Locomotor activity, Catalepsy, Hang test and SOD, MDA, GSH. respectively were estimated. The evaluation of anti-parkinsonism potential of extract evoked a significant dose dependent effect in haloperidol induced models as well as on biochemical parameters such as, SOD, GSH, MDA levels was observed by comparing with control group. The ethanolic extract of Psidium guajava leaves treated groups showed significant protection by reversing the levels of SOD, MDA, GSH as compared with control group. Histopathology observation also confirmed the neuroprotective property of Psidium guajava leaves. Ethanolic extract of Psidium guajava leaves possess significant anti-parkinsonism activity in haloperidol models. This observed activity of the plant attributed to the phytochemicals present in the extract.
Cite this article:
Rani Bhandarkavathe, Hugar Shivakumar, Nanjappaiah H. M., Virupanagouda P. Patil, Maharani Bhandarkavathe. Extract of Psidium guajava Attenuates Haloperidol Induced Parkinsonism like Symptoms in Wister albino rats. Research Journal of Pharmacy and Technology. 2025;18(4):1568-2. doi: 10.52711/0974-360X.2025.00224
Cite(Electronic):
Rani Bhandarkavathe, Hugar Shivakumar, Nanjappaiah H. M., Virupanagouda P. Patil, Maharani Bhandarkavathe. Extract of Psidium guajava Attenuates Haloperidol Induced Parkinsonism like Symptoms in Wister albino rats. Research Journal of Pharmacy and Technology. 2025;18(4):1568-2. doi: 10.52711/0974-360X.2025.00224 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-4-15
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