Author(s):
Santi Chismirina, Rachmi Fanani Hakim, Abdillah Imron Nasution, Citra Feriana Putri, Ade Oktaviary, Icha Chairunisa Firza, Suzanna Sungkar, Dewi Saputri, Kemala Hayati
Email(s):
santi_chismirina@usk.ac.id
DOI:
10.52711/0974-360X.2025.00221 
Address:
Santi Chismirina1*, Rachmi Fanani Hakim1, Abdillah Imron Nasution1, Citra Feriana Putri1, Ade Oktaviary1, Icha Chairunisa Firza1, Suzanna Sungkar2, Dewi Saputri3, Kemala Hayati4
1Departement of Oral Biology, Faculty of Dentistry, Universitas Syiah Kuala, Banda Aceh, 23111, Aceh.
2Departement of Pedodontic, Faculty of Dentistry, Universitas Syiah Kuala, Banda Aceh, 23111, Aceh.
3Departement of Periodontics, Faculty of Dentistry, Universitas Syiah Kuala, Banda Aceh, 23111, Aceh.
4Departement of Oral Radiology, Faculty of Dentistry, Universitas Syiah Kuala, Banda Aceh, 23111, Aceh.
*Corresponding Author
Published In:
Volume - 18,
Issue - 4,
Year - 2025
ABSTRACT:
Aloe vera is an herbal ingredient that contains acemannan, aloe emodin, vitamins (B1, B2, B6, B12, and C) and a number of minerals such as calcium, chlorine, chromium, copper, iron, magnesium, manganese, potassium, phosphorus, sodium, and zinc. So it has the potential to overcome bone resorption in periodontitis. This study aims to evaluate the effect of Aloe vera gel preparation on alveolar bone structure radiographically and microscopically in Wistar rats induced periodontitis. Induction of periodontitis was carried out for 14 days with the installation of 0.008 inch wire ligature in the cervical area of the maxillary first molar. In this study, rats were utilized to assess the effectiveness of periodontitis modification. Mice with periodontitis were divided into negative control, positive control group, and treatment group. Each group received gel base, metronidazole gel, and Aloe vera gel preparation. The test substance was applied every morning and evening for 14 days. The statistical analysis revealed a significant difference in alveolar bone density at p = 0.000 (p < 0.05). As a result, Aloevera gel preparation has an effect on the height and density of alveolar bone, as well as the microscopic structure and composition of alveolar bone in Wistar rats with periodontitis.
Cite this article:
Santi Chismirina, Rachmi Fanani Hakim, Abdillah Imron Nasution, Citra Feriana Putri, Ade Oktaviary, Icha Chairunisa Firza, Suzanna Sungkar, Dewi Saputri, Kemala Hayati. Evaluation of the Radiographic and Microscopical Impact of Aloe vera Gel Application on Alveolar Bone in Wistar Rats Exposed to Periodontitis. Research Journal of Pharmacy and Technology. 2025;18(4):1544-0. doi: 10.52711/0974-360X.2025.00221
Cite(Electronic):
Santi Chismirina, Rachmi Fanani Hakim, Abdillah Imron Nasution, Citra Feriana Putri, Ade Oktaviary, Icha Chairunisa Firza, Suzanna Sungkar, Dewi Saputri, Kemala Hayati. Evaluation of the Radiographic and Microscopical Impact of Aloe vera Gel Application on Alveolar Bone in Wistar Rats Exposed to Periodontitis. Research Journal of Pharmacy and Technology. 2025;18(4):1544-0. doi: 10.52711/0974-360X.2025.00221 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-4-12
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