ABSTRACT:
Hepatotoxicity and renal failure are two of the major complications of diabetes mellitus, among its numerous other complications. The primary cause of liver and kidney problems is the oxidative stress that is brought on by persistently high blood sugar levels. The current study aimed to assess the possible hepatic and nephron protective roles of a novel anti-diabetic poly herbal preparation containing dried leaves of Tinospora cordifolia, dried bark of Cinnamomum zeylanicum, dried seeds of Trigonella foenum, and dried seeds of Nigella sativa in streptozotocin (STZ) induced diabetic rats. Experimentally diabetes in Albino rats was induced by using streptozotocin. By examining several biochemical indicators to gauge their impact on the liver and kidney, diabetic rats were tested against an in-house prepared novel poly herbal formulation. Hepatic glycogen (HG), serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), alkaline phosphatase (ALP), total proteins (TP), total bilirubin (TB), direct (DB) and indirect bilirubin (IB), albumin, and globulin were used to measure the hepatoprotective efficacy. Blood urea nitrogen (BUN), urea, uric acid, and creatinine were used as kidney function markers to assess the nephroprotective potential. Six rats were placed in each of the thirteen groups, ethanolic extract polyherbal preparation was chosen for further testing of its hepatoprotective and nephroprotective potentials since it significantly reduced blood glucose levels in our prior trials. In streptozotocin-induced diabetic albino rats, the impaired liver and kidney functions significantly improved. The presence of active phytochemical ingredients may be the cause of the reversal of hepatic renal biochemical changes. Accordingly, the study came to the conclusion that the poly herbal combination (EHPH) efficiently heals diabetes-related liver and renal issues as well as prevents subsequent difficulties.