Author(s):
Farida Mindubayeva, Yuliya Niyazova, Yelena Salikhova, Mariya Ospanova, Zhanat Bolatbekuly, Lyudmila Akhmaltdinova, Diana Salekhova
Email(s):
yuliya_niyazova99@mail.ru , Salehova_89@mail.ru
DOI:
10.52711/0974-360X.2025.00178 
Address:
Farida Mindubayeva1, Yuliya Niyazova1*, Yelena Salikhova1*, Mariya Ospanova1, Zhanat Bolatbekuly2, Lyudmila Akhmaltdinova1, Diana Salekhova1
1NC JSC Karaganda Medical University, Karaganda, Kazakhstan.
2Pediatric Cardiac Surgery Department State Utility Company Multiprofile Hospital No. 2 of Karaganda of the Health Department of the Karaganda region, Karaganda, Kazakhstan.
*Corresponding Author
Published In:
Volume - 18,
Issue - 3,
Year - 2025
ABSTRACT:
The clinical picture at the initial stage of pulmonary arterial hypertension is scanty and nonspecific, especially in young children, which makes it difficult to diagnose PAH and control the course of the disease. On average 2.5 years pass before the appearance of pronounced clinical symptoms and diagnosis, when there are already irreversible changes in the pulmonary artery vascular wall. We present the results of studying the concentration of 5-hydroxyindoleacetic acid (5-HIAA) in blood plasma in young children with PAH before and after surgical correction of congenital heart defects. The revealed increase of 5-HIAA in plasma in children in the early postoperative period can be used in the diagnosis of PAH and serve as a criterion for assessing the regression of pulmonary hypertension.
Cite this article:
Farida Mindubayeva, Yuliya Niyazova, Yelena Salikhova, Mariya Ospanova, Zhanat Bolatbekuly, Lyudmila Akhmaltdinova, Diana Salekhova. 5-hydroxyindoleacetic Acid in the Diagnosis and Monitoring of PAH in Children after Congenital Heart Defect Surgical Correction. Research Journal of Pharmacy and Technology. 2025;18(3):1232-6. doi: 10.52711/0974-360X.2025.00178
Cite(Electronic):
Farida Mindubayeva, Yuliya Niyazova, Yelena Salikhova, Mariya Ospanova, Zhanat Bolatbekuly, Lyudmila Akhmaltdinova, Diana Salekhova. 5-hydroxyindoleacetic Acid in the Diagnosis and Monitoring of PAH in Children after Congenital Heart Defect Surgical Correction. Research Journal of Pharmacy and Technology. 2025;18(3):1232-6. doi: 10.52711/0974-360X.2025.00178 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-3-39
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