Author(s):
Chiquita Prahasanti, Rini Devijanti Ridwan, Alexander Patera Nugraha, Tansza Permata Setiana Putri5, Nastiti Faradilla Ramadhani, Diah Savitri Ernawati, Raden Darmawan Setijanto, Devi Rianti, Tania Saskianti, Ratri Maya Sitalaksmi, Shafira Kurnia Supandi, Ida Bagus Narmada, I Gusti Aju Wahju Ardani, Dwi Rahmawati, Fianza Rezkita, Andari Sarasati, Tengku Natasha Eleena Tengku Ahmad Noor
Email(s):
rini-d-r@fkg.unair.ac.id
DOI:
10.52711/0974-360X.2025.00168 
Address:
Chiquita Prahasanti1,2, Rini Devijanti Ridwan1,3, Alexander Patera Nugraha1,4, Tansza Permata Setiana Putri1,5, Nastiti Faradilla Ramadhani1,6, Diah Savitri Ernawati1,7, Raden Darmawan Setijanto1,8, Devi Rianti1,5, Tania Saskianti1,8, Ratri Maya Sitalaksmi1,9, Shafira Kurnia Supandi1,2, Ida Bagus Narmada1,4, I Gusti Aju Wahju Ardani1,4, Dwi Rahmawati1,4, Fianza Rezkita10, Andari Sarasati10, Tengku Natasha Eleena Tengku Ahmad Noor11,12
1Dental Implant Research Group, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia, 60132.
2Department of Periodontology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia, 60132.
3Department of Oral Biology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia, 60132.
4Department of Orthodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia, 60132.
5Department of Dental Material, Faculty of Dental Medicine, Universita
Published In:
Volume - 18,
Issue - 3,
Year - 2025
ABSTRACT:
Introduction: Periodontopathogenic bacteria are Gram-negative anaerobic bacteria that often cause peri-implantitis such as Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Fusobacterium nucleatum. Objective: This study is to analyze the periodontopathogen antibacterial properties of Polymethylmethacrylate (PMMA) and Hydroxyapatite (HA) composites against the growth of F. nucleatum, P. gingivalis, and A. Actinomycetemcomitans in vitro. Materials and Methods: Inhibition zone of PMMA-HA against periodontopathogenic bacteria was carried out with the well diffusion method. Doxycycline 100 mg was used as a positive control while the treatment group were consisted of 5 groups; 1) the PMMA group, 2) PMMA-HA from balai besar keramik (BBK), 3) PMMA-HA group of nano particle size, 4) the HA-BBK group and 5) the HA-nano group. All samples from the treatment and positive control groups were placed on agar plate that has been inoculated with bacteria are incubated for 24 hours at temperature of 37?C and were measured the inhibition zone diameter by using the digital caliper. The data was analysed using analysis of variance (ANOVA) and the post-hoc Tukey Honest Significant Different (HSD) test (p<0.05). Results: PMMA-HA has the ability to inhibit the growth of F. nucleatum, P. gingivalis, A. Actinomycetemcomitans in vitro. The antibacterial activity of PMMA-HA nanocomposite against F. nucleatum, P. gingivalis, and A. Actinomycetemcomitans was higher than PMMA-HA-BBK (p=0.0001; p<0.05). Conclusion: PMMA-HA nanocomposite has the ability to inhibit the growth of F. nucleatum, P. gingivalis, and A. Actinomycetemcomitans better than PMMA-HA-BBK which can be considered as a candidate for dental implant biomaterials with periodontopathogenic antibacterial property to prevent peri-implantitis.
Cite this article:
Chiquita Prahasanti, Rini Devijanti Ridwan, Alexander Patera Nugraha, Tansza Permata Setiana Putri5, Nastiti Faradilla Ramadhani, Diah Savitri Ernawati, Raden Darmawan Setijanto, Devi Rianti, Tania Saskianti, Ratri Maya Sitalaksmi, Shafira Kurnia Supandi, Ida Bagus Narmada, I Gusti Aju Wahju Ardani, Dwi Rahmawati, Fianza Rezkita, Andari Sarasati, Tengku Natasha Eleena Tengku Ahmad Noor. Periodontopathogen Antibacterial Properties of PMMA-HA as a Dental Implant Candidate Biomaterial in vitro. Research Journal Pharmacy and Technology. 2025;18(3):1166-1. doi: 10.52711/0974-360X.2025.00168
Cite(Electronic):
Chiquita Prahasanti, Rini Devijanti Ridwan, Alexander Patera Nugraha, Tansza Permata Setiana Putri5, Nastiti Faradilla Ramadhani, Diah Savitri Ernawati, Raden Darmawan Setijanto, Devi Rianti, Tania Saskianti, Ratri Maya Sitalaksmi, Shafira Kurnia Supandi, Ida Bagus Narmada, I Gusti Aju Wahju Ardani, Dwi Rahmawati, Fianza Rezkita, Andari Sarasati, Tengku Natasha Eleena Tengku Ahmad Noor. Periodontopathogen Antibacterial Properties of PMMA-HA as a Dental Implant Candidate Biomaterial in vitro. Research Journal Pharmacy and Technology. 2025;18(3):1166-1. doi: 10.52711/0974-360X.2025.00168 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-3-29
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