Author(s):
Purwaniati Purwaniati, Muhammad Insanu, Maria Immaculata Iwo, Rahmana Emran Kartasasmita
Email(s):
maria1428@itb.ac.id
DOI:
10.52711/0974-360X.2025.00166 
Address:
Purwaniati Purwaniati1,4, Muhammad Insanu2, Maria Immaculata Iwo3*, Rahmana Emran Kartasasmita1
1Departement of Pharmaceutical Chemistry, School of Pharmacy, Institut Teknologi Bandung, Bandung, Indonesia.
2Departement of Pharmaceutical Biology, School of Pharmacy, Institut Teknologi Bandung, Bandung, Indonesia
3Departement of Pharmacology and Clinical Pharmacy, School of Pharmacy, Institut Teknologi Bandung, Bandung, Indonesia.
4Departement of Pharmaceutical Analysis and Medicinal Chemistry, Pharmacy Faculty, Universitas Bhakti Kencana, Bandung, Indonesia.
*Corresponding Author
Published In:
Volume - 18,
Issue - 3,
Year - 2025
ABSTRACT:
Ginggiang (Leea aequata L.) leaf is widely recognized for its traditional applications in wound healing and palm sap preservation. Therefore, this research aimed to explore the potential of ginggiang leaf as a preservative or antiseptic agent, focusing on evaluating its antimicrobial properties. Flavonoids, tannins, saponins, quinones, terpenoids, and steroids were detected in the leaf's ethanol extract (EE) and aqueous extract (AE). In vitro assessments included the evaluation of AE and EE, as well as ethyl acetate, n-hexane, and 20%-methanol fraction of EE, to test inhibitory effects on the microbial test. The results showed that EE and AE, including ethyl acetate and 20%-methanol fraction, provided antimicrobial activity against several foodborne pathogens and skin disease microbes. However, only EE showed a significant antimicrobial effect against a spectrum of test microbes and the most potent antimicrobial activity, including Staphylococcus aureus with MIC 66.67±18.85 µg/mL, MRSA (160.00±0.00µg/mL), Staphylococcus epidermidis (168.0±102.14µg/mL), Propionibacterium acnes (426.67±122.67), Bacillus subtilis (426.67±150.85µg/mL), Pseudomonas aeruginosa (133.33±37.71 µg/mL), Escherichia coli (426.67±150.85µg/mL), Candida albicans (53.33±18.85µg/mL), and Aspergillus flavus (2560.00±0.00µg/mL). Based on this research, it can be concluded that EE from ginggiang leaf showed promising potential for further development as a preservative and antiseptic.
Cite this article:
Purwaniati Purwaniati, Muhammad Insanu, Maria Immaculata Iwo, Rahmana Emran Kartasasmita. The Antimicrobial activity of Ginggiang (Leea aequata L.) leaf extract as Preservative and Antiseptic. Research Journal Pharmacy and Technology. 2025;18(3):1154-0. doi: 10.52711/0974-360X.2025.00166
Cite(Electronic):
Purwaniati Purwaniati, Muhammad Insanu, Maria Immaculata Iwo, Rahmana Emran Kartasasmita. The Antimicrobial activity of Ginggiang (Leea aequata L.) leaf extract as Preservative and Antiseptic. Research Journal Pharmacy and Technology. 2025;18(3):1154-0. doi: 10.52711/0974-360X.2025.00166 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-3-27
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