Author(s):
Adryan Fristiohady, Taifo Mahmud, Nuralifah, Loly Subhiaty Idrus, La Ode M. J. Purnama, Lidya A Haruna, Tyaz Andarzia, Fery I. Armadany, Fadhliyah Malik, Rathapon Asasutjarit, Monsicha Khuanekkaphan, Idin Sahidin, Wahyuni Wahyuni
Email(s):
adryanfristiohady@uho.ac.id
DOI:
10.52711/0974-360X.2025.00151 
Address:
Adryan Fristiohady1, Taifo Mahmud2, Nuralifah1, Loly Subhiaty Idrus1, La Ode M. J. Purnama3, Lidya A Haruna3, Tyaz Andarzia1, Fery I. Armadany1, Fadhliyah Malik1, Rathapon Asasutjarit3, Monsicha Khuanekkaphan3, Idin Sahidin1, Wahyuni Wahyuni1
1Faculty of Pharmacy, Universitas Halu Oleo, Kendari 93232, Indonesia.
2Department of Pharmaceutical Sciences, Oregon State University, Corvallis, Oregon 97331-3507, United States of America.
3Thammasat University Research Unit in Drug, Health Product Development, and Application (DHP-DA), Department of Pharmaceutical Sciences, Faculty of Pharmacy.
*Corresponding Author
Published In:
Volume - 18,
Issue - 3,
Year - 2025
ABSTRACT:
This study aims to evaluate the anti-inflammatory activity of Lycopene in mice with ear oedema and in vitro activity. In this study, mice were used and performed in vitro anti-inflammatory tests of Lycopene with the HRBC method and protein denaturation. Moreover, the anti-inflammatory assay of Lycopene was also evaluated in xylene-induced right-ear mice. Diclofenac sodium solution was used as a positive control. The results showed that Lycopene provides anti-inflammatory activity in vitro by stabilizing the human red blood cell (HRBC), preventing lysis, and inhibiting protein denaturation with IC50 32.47 µg/ml. In addition, Lycopene also reduced the thickness of xylene-induced oedema in the right ear of mice. Lycopene provides anti-inflammatory properties by inhibiting HRBC lysis and protein denaturation and stabilizing HRBC, decreased the thickness of Oedema in the right ear of mice and the TNF-? levels.
Cite this article:
Adryan Fristiohady, Taifo Mahmud, Nuralifah, Loly Subhiaty Idrus, La Ode M. J. Purnama, Lidya A Haruna, Tyaz Andarzia, Fery I. Armadany, Fadhliyah Malik, Rathapon Asasutjarit, Monsicha Khuanekkaphan, Idin Sahidin, Wahyuni Wahyuni. Anti-Inflammatory Activities of Lycopene on Xylene-Induced Ear Oedema in Mice and its In-Vitro Evaluation towards Protein Denaturation. Research Journal Pharmacy and Technology. 2025;18(3):1052-7. doi: 10.52711/0974-360X.2025.00151
Cite(Electronic):
Adryan Fristiohady, Taifo Mahmud, Nuralifah, Loly Subhiaty Idrus, La Ode M. J. Purnama, Lidya A Haruna, Tyaz Andarzia, Fery I. Armadany, Fadhliyah Malik, Rathapon Asasutjarit, Monsicha Khuanekkaphan, Idin Sahidin, Wahyuni Wahyuni. Anti-Inflammatory Activities of Lycopene on Xylene-Induced Ear Oedema in Mice and its In-Vitro Evaluation towards Protein Denaturation. Research Journal Pharmacy and Technology. 2025;18(3):1052-7. doi: 10.52711/0974-360X.2025.00151 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-3-12
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