Author(s): Rao S. Prakash, Saraf Kumar Surendra, Baghel Madhuri, Vishwakarma Priyanka, Verma Khushboo Majumdar Ashish

Email(s): ashishmajumdar27@gmail.com , spr_pharma@yahoo.co.in

DOI: 10.52711/0974-360X.2025.00136   

Address: Rao S. Prakash1, Saraf Kumar Surendra2, Baghel Madhuri3, Vishwakarma Priyanka2, Verma Khushboo2 Majumdar Ashish2*
1Department of Pharmacognosy, SRIP, Kumhari, Durg, CG, India.
2Department of Pharmaceutics, Columbia College of Pharmacy, Raipur, 492001, CG, India.
3Department of Pharmaceutical Sciences, Apollo College of Pharmacy, Anjora Durg 491001(C.G), India.
*Corresponding Author

Published In:   Volume - 18,      Issue - 2,     Year - 2025


ABSTRACT:
Background: Autoimmune diseases, affecting over 5% globally, impose perplexing health burdens. Diabetes mellitus adds perplexity—cellular glucose impairment in type 2 diabetes, burstiness in elevated blood sugar, prevalent in youth. Type 1 Diabetes Mellitus intertwines with thyroid, celiac, and gastritis complexities, a perplexing maze. Objectives: Navigating the intricate labyrinth of Indian plant wisdom, this review delves into the perplexing terrain, renowned for its botanical diversity. Focused on managing immune disorders, particularly in diabetes mellitus, it bursts with information on anti-diabetic plants, blending conventional and commercial perspectives. Unfolding a narrative rich in the hypoglycemic properties of these botanical treasures, it offers a difficult insight into untangling the complexities of diabetes-related complications. Methods: A comprehensive search of databases including PubMed, Google Scholar, and other scholarly sources was conducted. The review focused on gathering data on anti-diabetic plants extensively utilized in India’s traditional medicine. Information regarding their hypoglycemic effects, traditional usage, and potential therapeutic benefits in managing diabetes and its complications was extracted and analyzed. Results: The review presents a compilation of numerous anti-diabetic plants employed in india's traditional medicine, highlighting their hypoglycemic properties and potential for managing diverse diabetes-related complications. The gathered information underscores the potential of these native plants as promising alternatives for diabetes management. Conclusion: The utilization of indigenous plants in traditional medicine for treating diabetes in India offers promising avenues for combating the propagation of diabetes. Further exploration and research on these plants are warranted to unveil their therapeutic mechanisms, prognostic implications, and development of specific clinical guidelines for managing type 1 & 2 diabetes mellitus effectively.


Cite this article:
Rao S. Prakash, Saraf Kumar Surendra, Baghel Madhuri, Vishwakarma Priyanka, Verma Khushboo Majumdar Ashish. Integrating Traditional Medicinal Plants into Diabetes Mellitus (Autoimmune Disease) Management in India: A review. Research Journal of Pharmacy and Technology.2025;18(2):927-4. doi: 10.52711/0974-360X.2025.00136

Cite(Electronic):
Rao S. Prakash, Saraf Kumar Surendra, Baghel Madhuri, Vishwakarma Priyanka, Verma Khushboo Majumdar Ashish. Integrating Traditional Medicinal Plants into Diabetes Mellitus (Autoimmune Disease) Management in India: A review. Research Journal of Pharmacy and Technology.2025;18(2):927-4. doi: 10.52711/0974-360X.2025.00136   Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-2-68


REFERENCES:
1.    Khan Z, Gupta G Das, Mehan S. Cellular and Molecular Evidence of Multiple Sclerosis Diagnosis and Treatment Challenges. J Clin Med. 2023;12(13). doi:10.3390/jcm12134274
2.    Gawda A, Majka G, Nowak B, Śróttek M, Walczewska M, Marcinkiewicz J. Air particulate matter SRM 1648a primes macrophages to hyperinflammatory response after LPS stimulation. Inflamm Res. 2018; 67(9): 765-776. doi:10.1007/s00011-018-1165-4
3.    Abbas AK, Murphy KM, Sher A. Functional diversity of helper T lymphocytes. Nature. 1996; 383(6603): 787-793. doi:10.1038/383787a0
4.    McCor-mack JE, Callahan JE, Kappler J, et al. 67. F. Vignaux and P. Golstein. 88 J B Weinb a!, ibid. 1994;10(March):497.
5.    Volkmar FR, State M, Klin A. Autism and autism spectrum disorders: Diagnostic issues for the coming decade. J Child Psychol Psychiatry Allied Discip. 2009; 50(1-2): 108-115. doi:10.1111/j.1469-7610.2008.02010.x
6.    Hoppe B, Beck BB, Milliner DS. The primary hyperoxalurias. Kidney Int. 2009; 75(12): 1264-1271. doi:10.1038/ki.2009.32
7.    Uppal P, Mohammed SA, Rajashekar S, et al. Type 2 Diabetes Mellitus and Asthma: Pathomechanisms of Their Association and Clinical Implications. Cureus. 2023; 15(3): 4-11. doi:10.7759/cureus.36047
8.    Kopf S, Kumar V, Kender Z, et al. Diabetic Pneumopathy–A New Diabetes-Associated Complication: Mechanisms, Consequences and Treatment Considerations. Front Endocrinol (Lausanne). 2021; 12(November):1-11. doi:10.3389/fendo.2021.765201
9.    Tripathi BK, Srivastava AK. Diabetes mellitus: Complications and therapeutics. Med Sci Monit. 2006; 12(7): 130-147.
10.    Zheng Y, Ley SH, Hu FB. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol. 2018; 14(2): 88-98. doi:10.1038/nrendo.2017.151
11.    Nathan DM, Buse JB, Davidson MB, et al. Management of hyperglycaemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy - A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia. 2006; 49(8): 1711-1721. doi:10.1007/s00125-006-0316-2
12.    Pola S, Kadali VN. Medicinal Plants of West Godavari. Drug Discov - Concepts to Mark. 2018. doi:10.5772/intechopen.73499
13.    Upadhyay RP, Misra P, Chellaiyan VG, et al. Burden of diabetes mellitus and prediabetes in tribal population of India: A systematic review. Diabetes Res Clin Pract. 2013; 102(1): 1-7. doi:10.1016/j.diabres.2013.06.011
14.    Wagner EH, Austin BT, Davis C, Hindmarsh M, Schaefer J, Bonomi A. Improving chronic illness care: Translating evidence into action. Health Aff. 2001; 20(6): 64-78. doi:10.1377/hlthaff.20.6.64
15.    Kapoor D, Bhardwaj AK, Kumar D, Raina SK. Prevalence of Diabetes Mellitus and Its Risk Factors among Permanently Settled Tribal Individuals in Tribal and Urban Areas in Northern State of Sub-Himalayan Region of India. Int J Chronic Dis. 2014; 2014: 1-9. doi:10.1155/2014/380597
16.    Sachdev B. Community based study on incidence of type 2 diabetes and hypertension among nomad tribal population of Rajasthan, India. Int J Sci Nat. 2011; 2(2): 296-301.
17.    Kala CP, Dhyani PP, Sajwan BS. Developing the medicinal plants sector in northern India: Challenges and opportunities. J Ethnobiol Ethnomed. 2006;2(August 2006). doi:10.1186/1746-4269-2-32
18.    Bhattacharya P, Prasad R, Bhattacharyya R, Asokan A. plants in four Indian states. 2008;59(December):35-44.
19.    Poincelot RP, Flagler J. People-Plant Relationships: Setting Research Priorities.; 2018. doi:10.1201/9780203743942
20.    Engelhart MD, Moughamian H. Book Reviews : Book Reviews. Educ Psychol Meas. 1968; 28(3): 951-951. doi:10.1177/001316446802800332
21.    Awad N, Gagnon M, Messier C. The Relationship between Impaired Glucose Tolerance, Type 2 Diabetes, and Cognitive Function. Vol 26.; 2004. doi:10.1080/13803390490514875
22.    Ali Hussain HEM. Hypoglycemic, hypolipidemic and antioxidant properties of combination of Curcumin from Curcuma longa, Linn, and partially purified product from Abroma augusta, Linn. in streptozotocin induced diabetes. Indian J Clin Biochem. 2002;17(2):33-43. doi:10.1007/BF02867969
23.    El AY, Abdel N, Azzaz KE, Mahmoud HI. diabetic rats. 2014;5(3):430-439. doi:10.5155/eurjchem.5.3.430
24.    Najib A, Hartati S, Elya B. In vitro bioassay of n-buthanol isolate of Acorus calamus L. on inhibitory of activity a-glucosidase. Int J PharmTech Res. 2011;3(4):2085-2088.
25.    Gholamhoseinian A, Shahouzebi B, Sharifi-far F. Inhibitory effect of some plant extracts on Pancreatic Lipase. Int J Pharmacol. 2010;6(1):18-24. doi:10.3923/ijp.2010.18.24
26.    Rajasekaran S, Sivagnanam K, Ravi K, Subramanian S. Hypoglycemic Effect of Aloe vera Gel on Streptozotocin-Induced. J Med Food. 2004;7(July 2003):61-66.
27.    Rimando AM, Cuendet M, Desmarchelier C, Mehta RG, Pezzuto JM, Duke SO. Cancer chemopreventive and antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol. J Agric Food Chem. 2002;50(12):3453-3457. doi:10.1021/jf0116855
28.    Senthil Amudhan M, Hazeena Begum V. Alpha-glucosidase inhibitory and hypoglycemic activities of Areca catechu extract. Pharmacogn Mag. 2008;4(15):223-227.
29.    Pahlavani N, Roudi F, Zakerian M, et al. Possible molecular mechanisms of glucose-lowering activities of Momordica charantia (karela) in diabetes. J Cell Biochem. 2019;120(7):10921-10929. doi:10.1002/jcb.28483
30.    Variya BC, Bakrania AK, Patel SS. Emblica officinalis (Amla): A review for its phytochemistry, ethnomedicinal uses and medicinal potentials with respect to molecular mechanisms. Pharmacol Res. 2016;111:180-200. doi:10.1016/j.phrs.2016.06.013
31.    Abd El Aty HE, Zaazaa AM, Mohamed SH, El Dayem SA, Foda F. Promising Therapeutic Efficacy of Trigonella-foenum graecum and Bone Marrow-Derived Mesenchymal Stem Cells on Skeletal Muscle Atrophy in Experimental Rat Model. Biointerface Res Appl Chem. 2023;13(2):1-19. doi:10.33263/BRIAC132.133
32.    Jangam A, Tirunavalli SK, Adimoolam BM, et al. Anti-inflammatory and antioxidant activities of Gymnema Sylvestre extract rescue acute respiratory distress syndrome in rats via modulating the NF-κB/MAPK pathway. Inflammopharmacology. 2023;31(2):823-844. doi:10.1007/s10787-022-01133-5
33.    Rather GJ, Hamiduddin H, Ikram M, Naquibuddin M. Formulation and in vitro Evaluation of Tablet Dosage form of Unani Anti-diabetic Powder Containing Gymnema sylvestre R. Br, Syzygium cuminii Linn. and Zingiber officinale Rosc. Pharmacognosy Res. 2023; 15(3): 566-577. doi:10.5530/pres.15.3.060
34.    Hazra K, Dutta S, Mandal AK, Ravte RK, Mitra A, Hazra J. Pharmacognostical and phytochemical blueprint of abroma augusta l. Stem bark. Indian J Nat Prod Resour. 2021; 12(2): 271-280. doi:10.56042/ijnpr.v12i2.24981
35.    Batiha GES, Akhtar N, Alsayegh AA, et al. Bioactive Compounds, Pharmacological Actions, and Pharmacokinetics of Genus Acacia. Molecules. 2022; 27(21): 1-22. doi:10.3390/molecules27217340
36.    Anokwuru CP, Sinisi A, Samie A, Taglialatela-Scafati O. Antibacterial and antioxidant constituents of Acalypha wilkesiana. Nat Prod Res. 2015; 29(12): 1180-1183. doi:10.1080/14786419.2014.983105
37.    Zhao Y, Li J, Cao G, et al. Ethnic, Botanic, Phytochemistry and Pharmacology of the Acorus L. Genus: A Review. Molecules. 2023;28(20). doi:10.3390/molecules28207117
38.    Venthodika A, Chhikara N, Mann S, Garg MK, Sofi SA, Panghal A. Bioactive compounds of Aegle marmelos L., medicinal values and its food applications: A critical review. Phyther Res. 2021;35(4):1887-1907. doi:10.1002/ptr.6934
39.    Vigbedor BY, Osei Akoto C, Kwakye R, Osei-Owusu J, Neglo D, Kwashie P. Antioxidant, antibacterial, antifungal activities and gas chromatographic fingerprint of fractions from the root bark of Afzelia africana. Int J Biochem Mol Biol. 2022; 13(6): 60-76.
40.    Urabee MC, Abdulsattar JO, Nasif ZN, Al-Garawi ZS. Extraction methods of Alhagi Maurorum (camel thorn) and its therapeutic applications. J Phys Conf Ser. 2021; 1853(1). doi:10.1088/1742-6596/1853/1/012053
41.    Alam A, Al Arif Jahan A, Bari MS, et al. Allium vegetables: Traditional uses, phytoconstituents, and beneficial effects in inflammation and cancer. Crit Rev Food Sci Nutr. 2023;63(23):6580-6614. doi:10.1080/10408398.2022.2036094
42.    Kaur S, Bains K. Aloe Barbadensis Miller (Aloe Vera) Pharmacological activities and clinical evidence for disease prevention. Int J Vitam Nutr Res. 2024; 94(3-4): 308-321. doi:10.1024/0300-9831/a000797
43.    Putra WE, Sustiprijatno, Hidayatullah A, Widiastuti D, Heikal MF, Salma WO. Virtual Screening of Natural Alpha-Glucosidase Inhibitor From Alpinia Galanga Bioactive Compounds As Anti-Diabetic Candidate. J Microbiol Biotechnol Food Sci. 2023;13(1):1-5. doi:10.55251/jmbfs.4353
44.    Phoswa WN, Mokgalaboni K. Comprehensive Overview of the Effects of Amaranthus and Abelmoschus esculentus on Markers of Oxidative Stress in Diabetes Mellitus. Life. 2023; 13(9). doi:10.3390/life13091830
45.    Pratap Singh R, Pattnaik AK. Anti-obesity potential of bioactive guided fractions of A nnona squamosa linn. leaves extract: a combination of in-vitro, in-vivo and in-silico studies along with profiling of lead compounds by HPTLC MS-MSn method. 3 Biotech. 2023;13(6):1-14. doi:10.1007/s13205-023-03603-1
46.    Maqsood R, Khan F, Ullah S, et al. Evaluation of Antiproliferative, Antimicrobial, Antioxidant, Antidiabetic and Phytochemical Analysis of Anogeissus dhofarica A. J. Scott. Antibiotics. 2023;12(2). doi:10.3390/antibiotics12020354
47.    Sable PD, Kadam KA, Gangurde HH, Chavan PS, Ingle PD. Medicinal and pharmacological action of various herbs on Diabetes mellitus: A review. IOSR J Pharm. 2023; 13(March):1-09.
48.    Ibrahim KG, Mukonowenzou NC, Usman D, Adeshina KA, Erlwanger KH. The potential of Artemisia species for use as broad-spectrum agents in the management of metabolic syndrome: a review. Arch Physiol Biochem. 2023; 129(3): 752-770. doi:10.1080/13813455.2021.1871761
49.    Sohail J, Zubair M, Hussain K, et al. Pharmacological activities of Artemisia absinthium and control of hepatic cancer by expression regulation of TGFβ1 and MYC genes. PLoS One. 2023; 18(4 APRIL): 1-27. doi:10.1371/journal.pone.0284244
50.    Núbia Alves Mariano TPG, Germano Guarim N, Marcos Pereira M, Lucilia K, Vanessa Gisele PS. Ethnobotanical and ethnopharmacological survey of medicinal species utilized in the Coqueiros Community, Brazils. Bol Latinoam y del Caribe Plantas Med y Aromat. 2022; 21(6): 671-715. doi:10.37360/blacpma.22.21.6.42
51.    Zhang W, Zhao Z, Chang L, Cao Y, Wang S, Kang C. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID- 19. The COVID-19 resource centre is hosted on Elsevier Connect, the company’ s public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories , such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source . These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. Atractylodis Rhizoma : A review of its traditional uses , phytochemistry, pharmacology, toxicology and quality control. 2020;(January).
52.    Satyanarayana K, Sravanthi K, Shaker I, Ponnulakshmi R. Molecular approach to identify antidiabetic potential of Azadirachta indica. J Ayurveda Integr Med. 2015; 6(3): 165-174. doi:10.4103/0975-9476.157950
53.    He X, Yang Y, Yuan X, Sun Y, Li Y. Anti-Nociceptive and Anti-Inflammatory Activities of the Ethyl Acetate Extract of Belamcanda chinensis (L.) Redouté in Raw 264.7 Cells in vitro and Mouse Model in vivo. J Pain Res. 2022; 15: 1221-1232. doi:10.2147/JPR.S353357
54.    Alsaadi SARA, Abass KS. Benincasa hispida is an antioxidant of possible physiological importance: A comparative review. Plant Arch. 2020;20:2833-2838.
55.    Belwal T, Bisht A, Devkota HP, et al. Phytopharmacology and Clinical Updates of Berberis Species Against Diabetes and Other Metabolic Diseases. Front Pharmacol. 2020; 11(February): 1-27. doi:10.3389/fphar.2020.00041
56.    Bouchmaa N, Mrid R Ben, Kabach I, et al. Beta vulgaris subsp. maritima: A Valuable Food with High Added Health Benefits. Appl Sci. 2022; 12(4). doi:10.3390/app12041866
57.    Anand U, Nandy S, Mundhra A, Das N, Pandey DK, Dey A. A review on antimicrobial botanicals, phytochemicals and natural resistance modifying agents from Apocynaceae family: Possible therapeutic approaches against multidrug resistance in pathogenic microorganisms. Drug Resist Updat. 2020; 51(March): 100695. doi:10.1016/j.drup.2020.100695
58.    Batiha GES, Alkazmi LM, Wasef LG, Beshbishy AM, Nadwa EH, Rashwan EK. Syzygium aromaticum l. (myrtaceae): Traditional uses, bioactive chemical constituents, pharmacological and toxicological activities. Biomolecules. 2020; 10(2): 1-17. doi:10.3390/biom10020202
59.    Dey P, Singh J, Suluvoy JK, Dilip KJ, Nayak J. Utilization of Swertia chirayita Plant Extracts for Management of Diabetes and Associated Disorders: Present Status, Future Prospects and Limitations. Nat Products Bioprospect. 2020; 10(6): 431-443. doi:10.1007/s13659-020-00277-7
60.    Khaliq T, Akhter S, Sultan P, Hassan QP. Critical review on Rumex dentatus L. a strong pharmacophore and the future medicine: Pharmacology, phytochemical analysis and traditional uses. Heliyon. 2023; 9(3): e14159. doi:10.1016/j.heliyon.2023.e14159
61.    Yahaya TO, Liman UU, Obadiah CD, et al. Environmental Triggers’ Involvement in the Development of Type 1 Diabetes Mellitus. Explor Res Hypothesis Med. 2022;000(000):000-000. doi:10.14218/erhm.2022.00051
62.    Zhang L, Wei K, Xu J, et al. Belamcanda chinensis (L.) DC-An ethnopharmacological, phytochemical and pharmacological review. J Ethnopharmacol. 2016; 186: 1-13. doi:10.1016/j.jep.2016.03.046
63.    Krishnamoorthy Y, Rajaa S, Verma M, Kakkar R, Kalra S. Spatial Patterns and Determinants of Diabetes Mellitus in Indian Adult Population: a Secondary Data Analysis from Nationally Representative Surveys. Diabetes Ther. 2023; 14(1): 63-75. doi:10.1007/s13300-022-01329-6
64.    Narayan KMV, Varghese JS, Beyh YS, et al. A Strategic Research Framework for Defeating Diabetes in India: A 21st-Century Agenda. J Indian Inst Sci. 2023; 103(1): 33-54. doi:10.1007/s41745-022-00354-5
65.    Nivedita Rawat, Sharddha Sharma. Role of Ayurvedic Medicinal Plants in Auto-immune disorders and their management. J Ayurveda Integr Med Sci. 2023; 8(3): 108-115. doi:10.21760/jaims.8.3.20
66.    Balwan WK, Saba N, Zargar JI. Burden of Diabetes and Role of Medicinal Plants in Its Treatment. Saudi J Med Pharm Sci. 2022; 8(7): 355-361. doi:10.36348/sjmps.2022.v08i07.006
67.    Khan W, Zahiruddin S, Ahmad S. Diabetes-Associated Complications and Some Indian Traditional Plants Used for Its Management. Vol 66. 1st ed. Elsevier B.V.; 2020. doi:10.1016/B978-0-12-817907-9.00005-2
68.    Ogbonna Abigail I, Ogbonna Sonia Ugoy A, Ugwu Eugene I, et al. Biochemical Analysis and Antimicrobial Activity of Ethanolic and Aqueous Leaf Extracts of Acalypha wilkesiana var morea Müll.Arg. (Copperleaf). J Bot Res. 2021; 4(1). doi:10.36959/771/570
69.    Hannan JMA, Nipa N, Toma FT, Talukder A, Ansari P. Acute Anti-Hyperglycaemic Activity of Five Traditional Medicinal Plants in High Fat Diet Induced Obese Rats. Front Biosci - Sch. 2023; 15(2). doi:10.31083/j.fbs1502005
70.    Ali Esmail Al-Snafi. Medicinal plants with hypoglycemic effect: A review. GSC Biol Pharm Sci. 2023; 24(1): 147-173. doi:10.30574/gscbps.2023.24.1.0274
71.    Gargantiel, Faller EM. A Perspective Review On Diabetes Mellitus And The Potential Antidiabetic Activity Of Medicinal Plants. Int J Sci Technol Res. 2021; 10(06): 188-202.
72.    Ahmad W, Amir M, Ahmad A, et al. Aegle marmelos leaf extract phytochemical analysis, cytotoxicity, in vitro antioxidant and antidiabetic activities. Plants. 2021; 10(12): 1-13. doi:10.3390/plants10122573
73.    Vellapandian C, Rini R, Ramachandram DS. Renoprotective activity of anethole- rich fraction from aromatic herbs on junk food induced diabetic nephropathy in rats. J Diabetes Metab Disord. 2022; 21(2): 1557-1567. doi:10.1007/s40200-022-01101-4
74.    Lochana L. Malode, Jagdish V. Manwar, Wrushali A. Panchale, Shivam A. Bartere, Ravindra L. Bakal. Potential of medicinal plants in management of diabetes: An updates. GSC Adv Res Rev. 2021; 8(1): 149-169. doi:10.30574/gscarr.2021.8.1.0151
75.    77.Biochemistry Research International - 2022 - Vigbedor - Bioassay‐Guided Fractionation  ESI‐MS Scan  Phytochemical Screening.pdf.

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