Author(s):
Sanjoy Majumder, Rutupurna Das, Gagan Kumar Panigrahi
Email(s):
gagan.panigrahi@cutm.ac.in
DOI:
10.52711/0974-360X.2025.00074 
Address:
Sanjoy Majumder1, Rutupurna Das2, Gagan Kumar Panigrahi2*
1School of Biotechnology, Centurion University of Technology and Management, Odisha, India.
2Department of Zoology, School of Applied Sciences, Centurion University of Technology and Management, Odisha-752050, India.
*Corresponding Author
Published In:
Volume - 18,
Issue - 2,
Year - 2025
ABSTRACT:
Cancer continues to be one of the major causes of human mortality across the globe. Current treatment options are not sufficient enough to control deaths caused by cancers and due to this there is high demand for urgent development of novel anticancer therapeutics. Since time immemorial plant materials are used either as food, drinks and flavor or as traditional medicines for the benefit of human health and wellbeing. Many studies have shown that some of the phytochemicals possess remarkable anti-cancer properties and can be utilized as potential anticancer therapeutics. There are many cellular pathways which are involved in the process of tumorigenesis. Many studies have shown the significance of involvement of nonsense mediated decay (NMD) pathway in cancer progression. Out of many proteins involved in NMD pathway Up-Frameshift (UPF) proteins UPF1, UPF2, UPF3A and UPF3B are most significant. Developing novel anticancer therapeutics through targeting the NMD pathway can be considered as a sustainable strategy towards good health and well-being (SDG 3). This current research aims to unravel the potential phytochemicals which targets the NMD pathway by modulating the function of UPF1 The molecular docking and in silico ADME analysis approach were used to screen the phytochemicals showing the ability to bind with human NMD factor UPF1.
Cite this article:
Sanjoy Majumder, Rutupurna Das, Gagan Kumar Panigrahi. Harnessing Phytochemicals to Modulate the Nonsense-mediated Decay Pathway for Anticancer Drug Discovery. Research Journal of Pharmacy and Technology.2025;18(2):489-4. doi: 10.52711/0974-360X.2025.00074
Cite(Electronic):
Sanjoy Majumder, Rutupurna Das, Gagan Kumar Panigrahi. Harnessing Phytochemicals to Modulate the Nonsense-mediated Decay Pathway for Anticancer Drug Discovery. Research Journal of Pharmacy and Technology.2025;18(2):489-4. doi: 10.52711/0974-360X.2025.00074 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-2-6
REFERENCES:
1. Marie-Ange Majérus. The cause of cancer: The unifying theory. Adv. Cancer Biol. – Metastasis. 2022; 4: 100034. doi.org/10.1016/j.adcanc.2022.100034.
2. Akshay R. Yadav, Shrinivas K. Mohite. Cancer- A Silent Killer: An Overview. Asian J. Pharm. Res. 2020; 10(3): 213-216.
3. OcranMattila, P. et al. Availability, Affordability, Access, and Pricing of Anti-Cancer Medicines in Low- and Middle-Income Countries: A Systematic Review of Literature. Front. Public Health. 2021; 9: 628744. doi.org/10.3389/fpubh.2021.628744.
4. Choudhari, A.S. et al. Phytochemicals in Cancer Treatment: From Preclinical Studies to Clinical Practice. Front. Pharmacol. 2020, 10, 1614. doi.org/10.3389/fphar.2019.01614.
5. Rutuja Sawant, Aloka Baghkar, Sanjukta Jagtap, Lina Harad, Anagha Chavan, Nilofar A. Khan, Rupali P. Yevale, Mohan K. Kale. A Review on - Herbs in Anticancer. Asian J. Res. Pharm. Sci. 2018; 8(4):179-184.
6. Anshul Sinha, A. K. Meena, P. Panda, Bhavana Srivastava, M. D. Gupta, M. M. Padhi. Phytochemical, Pharmacological and Therapeutic Potential of Hordeum vulgare Linn. - A Review. Asian J. Research Chem. 2012; 5(10): 1303-1308.
7. Sankalp Goswami, Prachi Sharma, Yogesh Shivhare. Phytopharmaceuticals as Cosmetic Agents: A Review. Res. J. Topical and Cosmetic Sci. 2011; 2(1): 11-13.
8. Mena, J. et al. Hydroethanolic Extracts of the AristoteliaChilensis (Maqui) Berry Reduces Cellular Viability and Invasiveness in the Endometrial Cancer Cell Line Ishikawa. Integr. Cancer Ther. 2021; 20: 15347354211007560. doi.org/10.1177/15347354211007560.
9. Rizeq, B. et al. The Power of Phytochemicals Combination in Cancer Chemoprevention. J. Cancer. 2020; 11(15): 4521-4533. doi.org/10.7150/jca.34374.
10. Mazurakova, A. et al. Anti-Prostate Cancer Protection and Therapy in the Framework of Predictive, Preventive and Personalised Medicine— Comprehensive Effects of Phytochemicals in Primary, Secondary and Tertiary Care. EPMA Journal. 2022; 13: 461-486. doi.org/10.1007/s13167-022-00288-z.
11. Chiatali O. Doke, Ranjit S. Tiwari, Vijay B. Todekar, Abhijeet P. Mane, Viraj S. Sawant, Ganesh V. Sawant. Herb Drug Interaction in Antibiotic Drug, Antiulcer Drug, Antihypertensive Drug, Antidiabetic Drug, Anticancer Drug. Research Journal of Science and Technology. 2023; 15(2): 119-6.
12. Prabhu Manickam Natarajan, Mohamed Abdullah Jaber, U. Vidhyarekha MDS, S. Bhuminathan, M.S. Nandini, Vijay Bhavrao Desai, Mohammad Kashif Shafiq Khot. Phytochemicals in Periodontal Bone Regeneration. Research Journal of Pharmacy and Technology. 2024; 17(2): 686-2. doi: 10.52711/0974-360X.2024.00106.
13. Jane B Mathew, Zakiya Fathima, Chaitra Raviraj, Arpith Mathew. Quantitative Estimation of Mangiferin and Molecular Docking Simulation of Salacia reticulata Formulation. Research Journal of Pharmacy and Technology. 2024; 17(2): 578-4. doi: 10.52711/0974-360X.2024.00090.
14. Panigrahi, G.K. et al. Bioactive Molecules from Plants: A Prospective Approach to Combat SARS-Cov-2. Advances in Traditional Medicine. 1-14, 2021.
15. Vanmugilan S, Sathish M, Suresh R. Screening of Oxystelma esculentum R.BR extracts for Acetylcholinesterase Inhibitory Activity. Research Journal of Pharmacy and Technology. 2024; 17(2): 467-0. doi: 10.52711/0974-360X.2024.00073.
16. Shalini A. Shinde, Manasi J. Mhetar, Avantika G. Parit, Akash R. Thombre. In-silico Investigation and ADMET Prediction of Potential Antifungal Phytochemicals against Lanosterol 14-Alpha Demethylase Inhibitors. Asian Journal of Pharmaceutical Research.2024;14(1):33-8.
17. Jesna M Joy, Reenu Jose Antony, Shanmuga Sundaram Rajagopal. Dietary Fiber Intake and Benefit of Colorectal Cancer. Asian J. Res. Pharm. Sci. 2019; 9(3): 209-214.
18. Poonam Gupta, Mohd. Yaqub Khan, Vikas Kumar Verma, Ashish Pathak. Beating Cancer with Natural Plant Sources. Asian J. Pharm. Tech. 2013; 3(2): April-June. 39-44.
19. Majrashi, T.A. et al. Insight into the Biological Roles and Mechanisms of Phytochemicals in Different Types of Cancer: Targeting Cancer Therapeutics. Nutrients. 2023; 15(7): 1704. doi.org/10.3390/nu15071704.
20. Pooja Singh, Divya Sharma, Akanksha Singh, Arjun Singh. A Comprehensive Review for Drug Target on Terminalia arjuna (Roxb.): Ethnopharmacological, Phytochemical, Pharmacognostical, and Clinical Significance. Asian Journal of Research in Chemistry. 2023; 16(6): 448-2.
21. Chen, B. et al. Up-frameshift Protein 1 Promotes Tumor Progression by Regulating Apoptosis and Epithelial-Mesenchymal Transition of Colorectal Cancer. Technol. Cancer Res. Treat. 2021; 20: 15330338211064438. doi.org/10.1177/15330338211064438.
22. Das, R and Panigrahi, G.K. Messenger RNA surveillance: current understanding, regulatory mechanisms and future implications. Molecular Biotechnology. 2024: 1-18.
23. Panigrahi, G.K., and Satapathy, K.B.. Sacrificed surveillance process favours plant defense: a review. Plant Archives 20.1: 2551-2559. 2020
24. Singh, A.K. et al. The RNA helicase UPF1 associates with mRNAs co-transcriptionally and is required for the release of mRNAs from gene loci. Elife. 2019; 8: e41444. doi.org/10.7554/eLife.41444.
25. Kim, Y.K., Maquat, L.E. UPFront and center in RNA decay: UPF1 in nonsense-mediated mRNA decay and beyond. RNA. 2019; 25: 407– 422. doi.org/10.1261/rna.070136.118.
26. Panigrahi, G.K., Sahoo, A., and Satapathy, K.B. Insights to plant immunity: Defense signaling to epigenetics. Physiological and Molecular Plant Pathology. 113: 1-7. 2021.
27. Patro, I., et al. Nonsense-Mediated mRNA Decay: mechanistic insights and physiological significance. Molecular Biotechnology: 1-15. 2023, doi.org/10.1007/s12033-023-00927-4.
28. Chen, B. et al. Up-frameshift Protein 1 Promotes Tumor Progression by Regulating Apoptosis and Epithelial–Mesenchymal Transition of Colorectal Cancer. Technol. Cancer Res. Treat. 2021, 20. doi.org/10.1177/15330338211064438.
29. Fang, L. et al. UPF1 increases amino acid levels and promotes cell proliferation in lung adenocarcinoma via the eIF2α-ATF4 axis. J. Zhejiang Univ. Sci. B 2022; 23(10): 863-875. doi.org/10.1631/jzus.B2200144.
30. Rahul Ashok Sachdeo, Manoj S. Charde, Ritu D. Chakole. Colorectal Cancer: An Overview. Asian J. Res. Pharm. Sci. 2020; 10(3): 211-223.
31. Chen, B. et al. UPF1: a potential biomarker in human cancers. Front. Biosci. (Landmark Ed) 2021; 26(5): 76–84. doi.org/10.52586/4925.
32. O'Boyle, N.M., Banck, M., James, C.A.; et al. Open Babel: An open chemical toolbox. J. Cheminform. 2011; 3: 33. doi.org/10.1186/1758- 2946-3-33.
33. Morris, G.M et al. Olson, A.J. Autodock4 and AutoDockTools4: automated docking with selective receptor flexibility. J. Computational Chemistry. 2009; 16: 2785-91.
34. Majumder and Panigrahi, G.K. The Evolution of Modern-day Drug Discovery and Development Processes: Current Understanding and Future Perspectives. African Journal of Biological Sciences (South Africa). 2024; 6(5): 1211-1234.
35. Trott, O., Olson, A.J. AutoDockVina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J. Comput. Chem. 2010; 31(2): 455-461. doi.org/10.1002/jcc.21334.
36. Radhika Chelamalla, Ajitha Makula. Molecular docking studies and ADMET Predictions of Pyrimidine Coumarin Scaffolds as Potential IDO Inhibitors. Asian J. Research Chem. 2017; 10(3): 331-340.
37. Saptarshi Samajdar. In silico ADME prediction of Phytochemicals present in Piper longum. Asian Journal of Research in Pharmaceutical Sciences. 2023; 13(2): 89-3.
38. Daina, A., Michielin, O., Zoete, V. SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. Sci. Rep. 2017; 7: 42717. doi.org/10.1038/srep42717.
39. Lipinski, C.A. Lead- and Drug-like Compounds: The Rule-of-Five Revolution. Drug Discovery Today: Technologies. 2004; 1: 337-341. doi.org/10.1016/j.ddtec.2004.11.007.
40. Veber, D.F. et al. Molecular properties that influence the oral bioavailability of drug candidates. J. Med. Chem. 2002; 45(12): 2615-2623. doi.org/10.1021/jm020017n.