ABSTRACT:
The article presents the results of research on the development of the composition and technology of a gel with ultrasonic ethanolic extract Portulaca oleracea L. for topical use. A gel under the conditional name PortoGel was taken as the object of the study. An ultrasonic ethanolic extract of Portulaca oleracea L. (POUS extract) was used as an active component. Since ancient times, the plant Portulaca oleracea L. has been used in traditional medicine in many countries to treat various diseases. A rational technology for producing the gel has been developed, and its indicators such as appearance, uniformity, smell, plasticity, viscosity, and pH have been studied. Sapineo Derm (sodium hydroxyethylacrylate/acryloyldimethyltaurate) was selected as a structure former. Sodium alginate is selected as a thickener and stabilizer. Boric acid, 0.1% Tea Tree oil extract as antimicrobial preservatives. Based on rheological studies (Brookfield HBDV-2), it was determined that PortoGel has optimal structural and mechanical characteristics, is a thixotropic system, sufficiently stable and pliable, capable of being spread on the skin, and provides the necessary stability of the system during technological operations. This study showed that the gel contains the active ingredient of Portulaca oleracea L. extract. It is promising for further work on the creation of medicines.