Author(s):
Sonal A. Shah, Gunvant H. Yeola, Priyadarshini Mohite, Abhijeet P. Shah, Santosh I. Swami, Dhanwantari H. Jha
Email(s):
gunvantayurved@gmail.com
DOI:
10.52711/0974-360X.2025.00090 
Address:
Sonal A. Shah1, Gunvant H. Yeola2*, Priyadarshini Mohite3, Abhijeet P. Shah4, Santosh I. Swami5, Dhanwantari H. Jha6
1HOD and Professor of Kayachikitsa at Loknete Rajarambapu Patil Ayurved College, P.G Institute and Research Centre, Islampur, Sangli.
1PhD Scholar of Dr D.Y. Patil College of Ayurved and Research Centre, Pimpri, Pune of Dr. D.Y. Patil Vidyapeeth (Deemed to be University), Pimpri, Pune 411018.
2Principal, Professor and HOD of Kayachikitsa at Dr. D.Y. Patil College of Ayurved and Research Centre, Pimpri, Pune of Dr D.Y. Patil Vidyapeeth (Deemed to be University), Pimpri, Pune 411018.
3P.G Student, Kayachikitsa Department, Loknete Rajarambapu Patil Ayurved College, P.G Institute and Research Centre, Islampur, Sangli.
4Asso. Professor, K.E. Society’s Rajarambapu Institute of Technology, Sakharale, Shivaji University, Kolhapur.
5Associate Professor, Department of Kayachikitsa, Seth Govindji Raoji Ayurved Mahavidyalaya, Solapur
PhD Scholar of Dr. D. Y. Patil Colle
Published In:
Volume - 18,
Issue - 2,
Year - 2025
ABSTRACT:
Background: Prediabetes phase indicates that a person is on the path to diabetes. In today’s life, prevalence of prediabetes is more than diabetes and rate of prediabetes getting converted into diabetes is also increasing. As rate of conversion from prediabetes to diabetic is more so it is important to reduce this rate of conversion. Material and methods: Exhaustive literature review has been carried out for the selection of relevant medicine for treatment of prediabetes. Mehamudgar Vatika has been selected for study against prediabetes as mentioned in Bhaishajya Ratnavali. Controlled clinical trial was used for the study. Ancient scholars of Ayurved have mentioned that it is effective in all sadhya-asadhaya Prameha. Result: The ingredients of Mehamudgar Vatika are having tikta-katu-kashaya rasa, ushna veerya, katuvipak and deepen pachan properties which rectify the Kleda predominance in prediabetes. Conclusion: Mehamudgar vati is effective in lowering the Kapha and Kleda as well as lowering the blood sugar level in prediabetic patients.
Cite this article:
Sonal A. Shah, Gunvant H. Yeola, Priyadarshini Mohite, Abhijeet P. Shah, Santosh I. Swami, Dhanwantari H. Jha. Controlled Clinical study of Mehamudgar Vatika in Prameha with special reference to Prediabetes. Research Journal of Pharmacy and Technology.2025;18(2):606-2. doi: 10.52711/0974-360X.2025.00090
Cite(Electronic):
Sonal A. Shah, Gunvant H. Yeola, Priyadarshini Mohite, Abhijeet P. Shah, Santosh I. Swami, Dhanwantari H. Jha. Controlled Clinical study of Mehamudgar Vatika in Prameha with special reference to Prediabetes. Research Journal of Pharmacy and Technology.2025;18(2):606-2. doi: 10.52711/0974-360X.2025.00090 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-2-22
REFERENCES:
1. Sushruta Maharshi. Avaraniya Adhava. In Kaviraia Ambikadutta shastri, editor. Sushruta Samhita with Ayurveda Tattava Sandipika Hindi commentary. Reprint Edition. Varanasi: Chaukhamba Sanskrit Samsthan; 2012. Vol-1, p 163.
2. Acharya Madhavkar, Prameha- Prameha pidaka nidanam Adhaya. Yadunandan Upadhyaya, editor. Madhav Nidan with Madhokosa commentary by Srivijayarakshit and Srikanta Dutta. 1st ed. Chaukhambha Prakashan: Varanasi. Reprinted 2013. Vol II, p 1-2.
3. Sushruta Maharshi. Pramehanidan Adhaya. In Kaviraja Ambikadutta shastri, editor. Sushruta Samhita with Ayurveda Tattava Sandipika Hindi commentary. Reprint Edition. Varanasi: Chaukhamba Sanskrit Samsthan; 2012. Vol-1, p 326.
4. Sushruta Maharshi. Pramehanidan Adhaya. In Kaviraja Ambikadutta shastri, editor. Sushruta Samhita with Ayurveda Tattava Sandipika Hindi commentary. Reprint Edition. Varanasi: Chaukhamba Sanskrit Samsthan; 2012. Vol-1, p 326.
5. Agnivesha. Pramehanidana Adhaya. In: Vaidya Acharya Jadavji Trikamji, editor. Charaka Saṃhita elaborated by Charaka and Dridhabala with Ayurveda-Dipika Commentary by Chakrapanidatta. 1st ed. Varanasi: Chaukhamba Prakashan; Reprinted 2013. p21
6. Smitha Elza Varghese, Nahomi Clement. Effectiveness of Structured Teaching Programme on Knowledge, Attitude and Practice regarding Home Care Management of Type II Diabetes Mellitus among Prediabetes patients in selected Wards of Chunakkara Panchayath, Aleppey District. Asian Journal of Nursing Education and Research. 2023; 13(2): 123-9. doi: 10.52711/2349-2996.2023.00027
7. Osadebe PO, Odoh EU, Uzor PF. The search for new hypoglycemic agents from plant. AfrJPharmPharmacol. 2014; 8(11): 292–303. doi: 10.5897/AJPP2014.3933.
8. Modak M, Dixit P, Londhe J, Ghaskadbi S, Devasagayam TPA. Indian herbs and herbal drugs used for the treatment of diabetes. J Clin Biochem Nutr. 2007; 40(3): 163. doi: 10.3164/jcbn.40.163.
9. Benito Johnson,D, Akhil Raj and Vekatanarayanan R.Antidiabetic activity and toxicity studies of ethanolic extracts of Polialthia longifolia roots. Research Journal of Pharmacy and Technology. 2017: 10(5); 05-12.
10. Tripathi, K. D. Essentials of medical pharmacology. (New Delhi: Jaypee Brothers Medical Publishers, 2008).
11. American Diabetes Association, A. Diagnosis, and classification of diabetes mellitus. Diabetes Care 33, (2010).
12. Boon, N. A., Colledge, N. R., Walker, B. R. and Hunter, J. Davidson’s principles and practice of medicine. (London: Churchill Livingstone, 2006).
13. Rang, H., Dale, M., Ritter, J., Flower, R., and Henderson, G. Rang and Dale’s pharmacology. (London: Churchill Livingstone, 2012).
14. Surendra Nath P, Rajeev.K, Arun Kumar, and Ashish Kumar P. Antidiabetics Review on natural products. Research Journal of Pharmacy and Technology. 2010; 3(2): 300-318.
15. Kazi S. Use of traditional plants in diabetes mellitus. Int J Pharm. 2014; 4(4): 283– [Google Scholar]
16. Bhutkar MA, Bhise SB. Spices and Condiments in the management of Diabetes mellitus. Research Journal of Pharmacy and Technology, 2100; 4(1): 37-42.
17. Nitin DD, Shruti Gupta, Birendra Shrivastav CD, Upasni KG and Apte Shaikh AM. Anti-diabetic potential of a polyherbal formulation- A review. Research Journal of Pharmacy and Technology. 2018; 11(6): 2625-2630
18. Santhose Kumar V, Praveen D. Sugar, and Chronic diseases. Research Journal of Pharmacy and Technology. 2016; 9(6): 650-654.
19. Ola H. Jasim, Majid M. Mahmood, Ali H. Ad’hiah. The significance of Liver Function Tests in detecting prediabetes as a prognostic factor. Research Journal of Pharmacy and Technology. 2022; 15(8): 3697-2. doi: 10.52711/0974-360X.2022.00620
20. Parisa Parsa, Roya Ahmadinia-Tabesh, Younes Mohammadi. Assessment of the risk of coronary heart disease in Diabetes Patients Type-II. Asian J. Nursing Education and Research. 2019; 9 (2): 267-270. doi: 10.5958/2349-2996.2019.00057.0
21. Thressia. P.A. (Sr. Tresa Anto) , Rajeev. Kumar. N. Effect of Sleep Duration on Obesity and the Glycemic level in Patients with Type 2 Diabetes. Asian J. Nur. Edu. and Research. 2014; 4(4): Oct.- Dec. 502-507.
22. Pandeya, S., Kumar, R., Kumar, A. and Pathak, K. A. Antidiabetics Review on Natural Products. Res. J. Pharm. Technol. 3, 300–318 (2010)
23. Malviya, N., Jain, S. and Malviya, S. Antidiabetic potential of medicinal plants. Acta Pol Pharm 67, 113–118 (2010).
24. Afrisham R, Aberomand M, Ghaffari MA, Siahpoosh A, Jamalan M. Inhibitory Effect of Heracleum persicum and Ziziphus jujuba on Activity of Alpha-Amylase. Journal of Botany. 2015; 2015: 1–8. doi: 10.1155/2015/824683. [Cross Ref] [Google Scholar]
25. Sindhu L, Jaya Kumar B. Effectiveness of Educational Intervention on Body Mass Index (BMI) of Patients with Type 2 Diabetes Mellitus in South Indian Population. Asian J. Nursing Education and Research. 2018; 8(3): 434-436. doi: 10.5958/2349-2996.2018.00088.5
26. A.G. Tabak, C. Herder, W. Rathmann, E.J. Brunner, M. Kivimaki Prediabetes _ A high-risk state for developing diabetes Lancet, 2012; 379: 2270-2290.
27. K.R. Srikantha Murthy. Charaka Samhita, Sutra Sthana ch.4 verse 47, First edition,2004, Chaukhamba Orientalia Varanasi, 586.
28. American Diabetes Association, Diagnosis, and classification of diabetes mellitus. Diabetes Care, 2011.34(Suppl 1): p. S62±69.6. Forouhi NG, Luan J., Hennings S,Wareham NJ, Incidence of type 2 diabetes in England and its association with baseline impaired fasting glucose: the Ely study 1990±2000.
29. Diabet Med, 2007. 24: p. 200±07.doi: 10.1111/j.1464-5491.2007. 02068.x PMID: 17257284 de Vegt Femmie, Dekker J.M., Agnes Jager, Ellen Hienkens, Kostense Pieter J., Coen D.A. et al., Relation of impaired fasting and postload glucose with incident of type 2 diabetes in a Dutch population:
30. The Hoorn studies. JAMA, 2001. 285: p. 2109±2113. PMID: 11311100
31. Yeboah J, Bertoni AG., Herrington DM, Post WS,Burke GL, Impaired Fasting Glucose and the risk of incident diabetes mellitus and cardiovascular events in an adult population: MESA (Multi-Ethnic Study of Atherosclerosis). J Am Coll Cardiol, 2011. 58: p. 140±46. doi: 10.1016/j.jacc.2011.03.025 PMID: 21718910
32. Levitzky Yamini S., Pencina M.J., D'Agostino Ralph B., Meigs James B., Murabito Joanne M., et al., Impact of impaired fasting glucose on cardiovascular disease: the Framingham Heart Study. J Am Coll Cardiol 2008. 51: p. 264±270. doi: 10.1016/j.jacc.2007.09.038 PMID: 18206734
33. Gerstein HC, Santaguida P., Raina P, Morrison KM, Balion C, Hunt D, et al., Annual incidence and relative risk of diabetes in people with various categories of dysglycemia: a systematic review and metanalysis of prospective studies. Diabetes Res Cli Pract, 2007. 78(3): p. 305±12.
34. Knowler WC., Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. The New England Journal of Medicine, 2002. 346(6): p. 393±403. doi: 10.1056/NEJMoa012512 PMID: 11832527
35. Mamatha M K, Suma US, Annegowda HV. The Ascent of Polyherbal Formulation in the Treatment of Diabetes Mellitus. Res. J. Pharmacognosy and Phytochem. 2020; 12(4): 256-260. doi: 10.5958/0975-4385.2020.00042.4
36. Narendra Garg, Sanjay Kumar, Surya Prakash, Manoj Sharma, Dhanraj Nagar. Role of Yava and Madhu in Prevention and Control of Diabetes Mellitus. Res. J. Pharmacognosy and Phytochem. 2018; 10(1): 73-76. doi: 10.5958/0975-4385.2018.00012.2
37. Dharmesh Sharma, Deepak Prashar, Sanjay Saklani. Bird’s Eye View on Herbal Treatment of Diabetes. Asian J. Pharm. Res. 2012; 2(1): Jan.-Mar. 01-06.
38. Yadavaji Trikamji; Charak Samhita; Choukamba Prakashan; 2008; Edition; part-I;Nidan 4; Page-630
39. Bhishgvarshrigovinddas sangruhita, Bhaishyajya Ratnavali, vimarsh - tippanisahit-‘vidyotini bhashatikopeta, Prameha chikitsa adhyay no 37, sholka no.69-72 Page no-727
40. B.Shastri, Yogratnakar, Chaukhamba Prakashan, Varanasi, reprint 2012, Uttarardha, Prameha Chikitsa, page no 82.
41. WHO DFC sponsored project on Devaloping Guidelines for Clinical Research Methodology in Ayurveda – Prof. M.S Baghel. Gradation of Symptoms: Medovaha Srotas 3.8, Pg no. 65,66.
42. WHO DFC sponsored project on Devaloping Guidelines for Clinical Research Methodology in Ayurveda – Prof. M.S Baghel. Gradation of Symptoms: Medovaha Srotas 3.8, Pg no. 67