Author(s):
R. Priyadharseni, Dhinesh. R, S. Nagalakshmi
Email(s):
nagalakshmi.s@sriramachandra.edu.in
DOI:
10.52711/0974-360X.2025.00081 
Address:
R. Priyadharseni1, Dhinesh. R2, S. Nagalakshmi3
1JSS College of Pharmacy, Post No-20, Rocklands, Ooty, Nilgiris - 643001.
2Sri Ramachandra Faculty of Pharmacy, SRIHER (DU), Porur, Chennai - 600116.
3Sri Ramachandra Faculty of Pharmacy, SRIHER(DU), Porur, Chennai - 600116.
*Corresponding Author
Published In:
Volume - 18,
Issue - 2,
Year - 2025
ABSTRACT:
This study aimed at fabricating a novel electrospun sandwich-structured polylactide–polyglycolide (PLGA)/collagen nanofibrous membranes. For the electrospinning of biodegradable membranes, PLGA/collagen and PLGA/ofloxacin were separately dissolved in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP). They were then electrospun into sandwich structured membranes, with PLGA/collagen for the surface layers and PLGA/OFL for the core layer. After electrospinning, various characterization studies were carried out for the prepared nanofibrous scaffold. The morphology of spun PLGA/collagen/OFL nanofibers was examined by scanning electron microscopy. The average diameter of electrospun nanofibers was 59 nm (range of 58–66 nm). The nature of the scaffold was determined by X-ray diffraction studies and rate of drug release was studied through in vitro activity. The experiment showed that biodegradable nanofibrous membranes released a sustainable concentration of drugs for a defined period of 8 hours. This would be a potential biomaterial in the field of corneal tissue engineering. The empirical results obtained from this study indicate that electrospun drug loaded sandwich PLGA/collagen nanofibers may be a good candidate for corneal damage.
Cite this article:
R. Priyadharseni, Dhinesh. R, S. Nagalakshmi. Fabrication of Drug Loaded Tissue Engineered Cornea with Collagen and Poly-lactic Glycolic acid (PLGA) Sandwich Hybrid Construct Electrospun Mat. Research Journal of Pharmacy and Technology.2025;18(2):545-0. doi: 10.52711/0974-360X.2025.00081
Cite(Electronic):
R. Priyadharseni, Dhinesh. R, S. Nagalakshmi. Fabrication of Drug Loaded Tissue Engineered Cornea with Collagen and Poly-lactic Glycolic acid (PLGA) Sandwich Hybrid Construct Electrospun Mat. Research Journal of Pharmacy and Technology.2025;18(2):545-0. doi: 10.52711/0974-360X.2025.00081 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-2-13
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