Author(s):
Amitha Ramesh, Ayush Gupta, Avaneendra Talwar, Pranav Murthy, Shraddha Kabra
Email(s):
Email ID Not Available
DOI:
10.52711/0974-360X.2025.00868 
Address:
Amitha Ramesh1, Ayush Gupta2, Avaneendra Talwar3, Pranav Murthy4, Shraddha Kabra5
1Head of the Department of Periodontology at ABSMIDS, Mangalore, India.
2Post Graduate Student of Periodontology at ABSMIDS, Mangalore, India.
3Professor in Department of Periodontology at ABSMIDS, Mangalore, India.
4Post Graduate Student of Periodontology at ABSMIDS, Mangalore, India.
5Post Graduate Student of Periodontology at ABSMIDS, Mangalore, India.
*Corresponding Author
Published In:
Volume - 18,
Issue - 12,
Year - 2025
ABSTRACT:
Background: Chronic desquamative gingivitis (CDG) is an inflammatory condition often linked to immune-mediated disorders. Oxidative stress plays a role in periodontal damage and can be assessed using salivary malondialdehyde (MDA) and superoxide dismutase (SOD). This study evaluates changes in these markers before and after nonsurgical periodontal therapy. Aim: To assess and compare salivary MDA and SOD levels in CDG patients before and after nonsurgical periodontal treatment. Methodology: The study included 46 participants (23 CDG patients, 23 healthy controls). Salivary MDA and SOD levels were measured biochemically. CDG patients underwent nonsurgical periodontal therapy, and post-treatment samples were collected after 10 days. Data were analyzed using t-tests. Results: No significant changes were observed in MDA (p = 0.712) or SOD (p = 0.385) levels post-treatment. Additionally, no significant differences were found between CDG patients and healthy controls (MDA: p = 0.576, SOD: p = 0.333). Conclusion: Nonsurgical periodontal therapy had no significant effect on oxidative stress markers in CDG. Oxidative stress levels in CDG patients were comparable to healthy individuals, indicating a limited role in disease progression. Clinical Significance: These findings highlight the need for further research into alternative therapeutic strategies for managing CDG.
Cite this article:
Amitha Ramesh, Ayush Gupta, Avaneendra Talwar, Pranav Murthy, Shraddha Kabra. Evaluation and Comparison of Salivary Malondialdehyde and Superoxide Dismutase Levels As Oxidative Stress Markers in Chronic Desquamative Gingivitis before and after Nonsurgical Periodontal Therapy – A Biochemical Study. Research Journal Pharmacy and Technology. 2025;18(12):6011-5. doi: 10.52711/0974-360X.2025.00868
Cite(Electronic):
Amitha Ramesh, Ayush Gupta, Avaneendra Talwar, Pranav Murthy, Shraddha Kabra. Evaluation and Comparison of Salivary Malondialdehyde and Superoxide Dismutase Levels As Oxidative Stress Markers in Chronic Desquamative Gingivitis before and after Nonsurgical Periodontal Therapy – A Biochemical Study. Research Journal Pharmacy and Technology. 2025;18(12):6011-5. doi: 10.52711/0974-360X.2025.00868 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-12-58
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