Author(s): Dian Paramita Kartikasari, Achmad Lefi, Fajar Perdhana, Yan Efrata Sembiring

Email(s): d.paramita.kartikasari@fk.unair.ac.id

DOI: 10.52711/0974-360X.2025.00842   

Address: Dian Paramita Kartikasari1,2,3*, Achmad Lefi1,2, Fajar Perdhana2,4, Yan Efrata Sembiring2,5
1Department of Cardiology and Vascular Medicine Subspecialty Program, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
2Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.
3Universitas Airlannga Hospital, Surabaya, Indonesia.
4Department of Anaesthesiology and Reanimation, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
5Department of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
*Corresponding Author

Published In:   Volume - 18,      Issue - 12,     Year - 2025


ABSTRACT:
Background: Coronary artery fistulas (CAFs) are uncommon coronary anomalies that create left-to-right shunts and turbulent flow, predisposing to endothelial injury and, rarely, infective endocarditis (IE). Case: A 25-year-old woman presented with acute parietal cortical–subcortical infarction. Transthoracic echocardiography revealed mobile vegetations on the right coronary and non-coronary aortic cusps. Blood cultures yielded Gemella morbillorum. During surgery for aortic valve replacement, intraoperative transesophageal echocardiography (TEE) incidentally identified a 7-mm fistulous connection from the right coronary artery to the right atrium, which was closed surgically. Outcome: Post-operative recovery was uneventful with hemodynamic stability. Conclusion: This case underscores the importance of comprehensive imaging to detect concealed CAFs in young IE patients without classic risk factors. Turbulent shunting through a CAF may facilitate bacterial colonization and embolic complications; early surgical management of both valve pathology and fistulous tract can be curative.


Cite this article:
Dian Paramita Kartikasari, Achmad Lefi, Fajar Perdhana, Yan Efrata Sembiring. Right Coronary Artery-Right Atrial Fistula, Stroke and Infective Endocarditis in Young Women: A Case Report. Research Journal Pharmacy and Technology. 2025;18(12):5839-2. doi: 10.52711/0974-360X.2025.00842

Cite(Electronic):
Dian Paramita Kartikasari, Achmad Lefi, Fajar Perdhana, Yan Efrata Sembiring. Right Coronary Artery-Right Atrial Fistula, Stroke and Infective Endocarditis in Young Women: A Case Report. Research Journal Pharmacy and Technology. 2025;18(12):5839-2. doi: 10.52711/0974-360X.2025.00842   Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-12-32


REFERENCES:
1.    Li N, Zhao P, Wu D, Liang C. Coronary artery fistulas detected with coronary CT angiography: a pictorial review of 73 cases. Br J Radiol. 2020 Apr 1;93(1108). 
2.    Torres S, Vasconcelos M, Tavares Silva M, Moreira J, Silva JC, Macedo F. Coronary artery fistulas: A 12-year single-center experience. Revista Portuguesa de Cardiologia. 2022 Oct;41(10):843–50. 
3.    Shah K, Jobanputra Y, Sharma P. Recurrent Bacteremia in the Setting of a Coronary Artery Fistula. Cureus. 2020 Jul 20; 
4.    Liesenborghs L, Meyers S, Vanassche T, Verhamme P. Coagulation: At the heart of infective endocarditis. Journal of Thrombosis and Haemostasis. 2020 May; 18(5): 995–1008. 
5.    Aslani AO, Haryawan Z, Sabrawi TA, Wibowo RH, Dewi AU. Embolization of infective endocarditis vegetation causes intracranial hemorrhage with hemorrhagic transformation after ischemic stroke. Glob Cardiol Sci Pract. 2023 Dec 7;2024(1). 
6.    Heiro M, Nikoskelainen J, Engblom E, Kotilainen E, Marttila R, Kotilainen P. Neurologic Manifestations of Infective Endocarditis. Arch Intern Med. 2000 Oct 9; 160(18): 2781. 
7.    Grecu N, Tiu C, Terecoasa E, Bajenaru O. Endocarditis and stroke. Maedica (Bucur). 2014 Dec; 9(4): 375–81. 
8.    Monesha Gupta. Coronary Artery Fistula Workup. Medscape. 2020. 
9.    Ouchi K, Sakuma T, Ojiri H. Coronary artery fistula in adults: Incidence and appearance on cardiac computed tomography and comparison of detectability and hemodynamic effects with those on transthoracic echocardiography. J Cardiol. 2020 Dec;76(6):593–600. 
10.    Green T, Crilley J. Endocarditis and coronary artery fistula: a case report†. Eur Heart J Case Rep. 2018 Mar 1;2(1). 
11.    Bittencourt MS, Seltman M, Achenbach S, Rost C, Ropers D. Right coronary artery fistula to the coronary sinus and right atrium associated with giant right coronary enlargement detected by transthoracic echocardiography. European Journal of Echocardiography. 2011 Mar 1;12(3):E22–E22. 
12.    Rodríguez EA, Martinez Soley TM, Restrepo CE, Medrano CA, Vargas Pelaez AF, Pérez de la Hoz RA. Multiple Coronary Artery Fistulas and 3-Vessel Disease in an Elderly Patient With Unstable Angina. JACC Case Rep. 2025 Sep; 30(28): 105072. 
13.    Yun G, Nam TH, Chun EJ. Coronary Artery Fistulas: Pathophysiology, Imaging Findings, and Management. Radio Graphics. 2018 May; 38(3):688–703. 
14.    Sahebjam M, Toofaninejad N, Biranvand H, Dehghani Firoozabadi M, Asl Fallah S, Kafashi M, et al. Infective Endocarditis of a Coronary Artery Fistula With Aortic Valve Involvement. CASE. 2025 Apr; 9(4): 124–9. 
15.    Tanaka Y, Yoshida J, Kashiwagi Y, Kunihara T, Yoshimura M. The significance of investigation into underlying coronary artery fistula in patients with tricuspid valve endocarditis: a case report. Eur Heart J Case Rep. 2025 May 30; 9(6). 
16.    Ahmed A, Alkodami LA, AlMuhaya MA, Al-Zubaidi SA, Uddin N, Almutairi M. Surgical Management of a Right Coronary Artery Fistula After Failed Transcatheter Closure: A Case Report. Cureus. 2025 Mar 10; 
17.    Al-Hijji M, El Sabbagh A, El Hajj S, AlKhouli M, El Sabawi B, Cabalka A, et al. Coronary Artery Fistulas. JACC Cardiovasc Interv. 2021 Jul; 14(13): 1393–406. 
18.    Lim ECN, Lim CED. Coronary Artery Fistula Presenting With Coronary Steal Syndrome: The Significance of Clinical Vigilance and Second Opinions. Clin Case Rep. 2025 Sep 11;13(9). 
19.    Youssef D, Youssef I, Marroush TS, Sharma M. Gemella endocarditis: A case report and a review of the literature. Avicenna J Med. 2019 Oct 9;09(04):164–8. 
20.    Vogkou CT, Vlachogiannis NI, Palaiodimos L, Kousoulis AA. The causative agents in infective endocarditis: a systematic review comprising 33,214 cases. European Journal of Clinical Microbiology & Infectious Diseases. 2016 Aug 11;35(8):1227–45. 
21.    Tanveer F, Pawlak J, Youssef D, Saravolatz LD. A case of Gemella morbillorum native valve endocarditis and results of in vitro susceptibility testing. IDCases. 2021;23:e01045. 
22.    Cao X, Yuan L. Gemella morbillorum infective endocarditis: A case report and literature review. Open Life Sci. 2023 May 18;18(1). 
23.    Shahani L. Gemella morbillorum prosthetic aortic valve endocarditis. BMJ Case Rep. 2014 Nov 18;2014:bcr2014207304. 
24.    Prewitt KC, Smolin MR, Coster TS, Vernalis MN, Bunda M, Wortham DC. Coronary Artery Fistula Diagnosed by Transesophageal Echocardiography. Chest. 1994 Mar;105(3):959–61. 
25.    Vitarelli A, De Curtis G, Conde Y, Colantonio M, Di Benedetto G, Pecce P, et al. Assessment of congenital coronary artery fistulas by transesophageal color Doppler echocardiography. Am J Med. 2002 Aug;113(2):127–33. 
26.    Jabri A, Shahrori Z, Nasser MF, Bullinger K, Alameh A, Haddadin F, et al. Right Coronary Artery to Right Atrial Fistula: Role of Multi-Modality Imaging and Percutaneous Closure. Cureus. 2022 Jul 10; 
27.    Kumar R, Kumar J, O’Connor C, Ullah I, Tyrell B, Pearson I, et al. Coronary Artery Fistula: A Diagnostic Dilemma. Interventional Cardiology: Reviews, Research, Resources. 2023 Nov 23;18. 
28.    Tang W, Xiang K, Zhou H, Li Y, Yang J, Liu J, et al. Case report: Surgical management of a rare right coronary artery fistula with a giant pseudoaneurysm compressing the pulmonary vein in a young patient. Front Cardiovasc Med. 2023 Sep 13;10. 
29.    Yeon MH, Choi YR, Lee SY, Bae JW, Hwang KK, Kim DW, et al. A Rare Combination of the Left Circumflex Coronary Artery Fistula Connecting a Dilated Coronary Sinus with Persistent Left Superior Vena Cava and Multiple Arteriovenous Fistulae. Korean Circ J. 2013;43(5):356. 
30.    Goo HW. Imaging Findings of Coronary Artery Fistula in Children: A Pictorial Review. Korean J Radiol. 2021;22(12):2062. 
31.    Erba PA, Pizzi MN, Roque A, Salaun E, Lancellotti P, Tornos P, et al. Multimodality Imaging in Infective Endocarditis. Circulation. 2019 Nov 19;140(21):1753–65.

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