ABSTRACT:
Orally disintegrating tablets (ODTs) are one of the drug delivery systems with high acceptance and compliances. The major advantage of ODTs is drug administration any time without water; self-medication and stability compared to parenteral which increased patient compliances. Orally disintegrating tablets (ODTs) which have ideal properties and desired characteristics have remarkable impact on the patient compliance. The main characteristics required for ODTs to be successful are that they don't require water for oral administration, dissolve, disperse, or disintegrate in the mouth in a matter of seconds, have a high bioavailability, start working therapeutically quickly, are less sensitive to temperature and humidity to maintain stability, and use an economical production process that includes packaging. Furthermore, desirable properties for ODTs include swallowability, drug dissolving in saliva, high drug loading, and prevention of tablet size growth. Leaves of Piper betel possess several bioactivities and are used in traditional medicinal systems. The goal is to demonstrate the potential impact of this plant on the creation of herbal medications with therapeutic effects. Phenolic compounds present in the Piper betel inhibit the lipid peroxidation and had the ability to prevent oxidative DNA damage. The hydrophobic parts of the compound may enable them to partition the lipids of the bacterial cell membrane, thereby disturbing the structures and rendering them more permeable. According to the study's findings, direct compression has a major impact on the drug's release, disintegration time, and % friability. It is thus concluded that direct compression is a better option for the formulation of Oral disintegrating tablet (ODT).