Author(s):
Priya Sharma, Archana Kumari, Versha Sharma, Shivali
Email(s):
bhpriya02@gmail.com
DOI:
10.52711/0974-360X.2025.00736 
Address:
Priya Sharma1*, Archana Kumari1, Versha Sharma2, Shivali3
1School of Pharmacy and Emerging Sciences, Baddi University of Emerging Sciences & Technology, Baddi, District- Solan, H.P., India.
2Himachal Pharmacy College, Maganpura, Nalagarh, Solan-174101, Himachal Pradesh, India.
3Gautam College of Pharmacy, District - Hamirpur, H.P., India.
*Corresponding Author
Published In:
Volume - 18,
Issue - 10,
Year - 2025
ABSTRACT:
Leukemia is a major health concern where blood forming materials are involved within the cancer factor. Thus, the treatment of leukemia currently relies on typical modalities like chemotherapy as well as radiation therapy. But it is the part that nutrition has to play in relation to the prevention and handling of its consequence that has gained increasing notice among the medical circles globally. Accordingly, it shall establish a view on the literature in relation to diet manipulation, supplements, as well as exercise and other bodily behaviors that can effectively work towards controlling the occurrence of leukemia and influencing its treatment outcomes. Attempts are made to determine how such diets affect the development of the disease by considering mechanisms related to diet-induced leukemia. Dietary patterns and individual nutrients in regard to leukemia prevention and treatment are described. Decisions are made regarding nutraceuticals/functional foods in the context of dietetics’ impact on usual medication used to counter leukemia. Thus, it is our intention in this study to provide a summation of what we have known up to this point and ask a few more questions for the subsequent researches to answer for those physicians or scientists who keen to understand the relationship between nutritional processes and incidence of leukemia cases around us.
Cite this article:
Priya Sharma, Archana Kumari, Versha Sharma, Shivali. The Role of Nutrition in Leukemia: A Comprehensive Review of Diet, Supplements and Lifestyle Choices. Research Journal of Pharmacy and Technology. 2025;18(10):5097-0. doi: 10.52711/0974-360X.2025.00736
Cite(Electronic):
Priya Sharma, Archana Kumari, Versha Sharma, Shivali. The Role of Nutrition in Leukemia: A Comprehensive Review of Diet, Supplements and Lifestyle Choices. Research Journal of Pharmacy and Technology. 2025;18(10):5097-0. doi: 10.52711/0974-360X.2025.00736 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-10-75
REFERENCES:
1. Kumar D, Jain N, Khurana A, Mittal S, Satapathy SC, Senkerik R, Hemanth JD. Automatic detection of white blood cancer from bone marrow microscopic images using convolutional neural networks. IEEE Access. 2020; Jul 27; 8: 142521-31. DOI: 10.1109/ACCESS.2020.3012292
2. Teras LR, DeSantis CE, Cerhan JR, Morton LM, Jemal A, Flowers CR. 2016 US lymphoid malignancy statistics by World Health Organization subtypes. CA: a Cancer Journal for Clinicians. 2016; Nov 12; 66(6): 443-59. https://doi.org/10.3322/caac.21357
3. Falini B, Brunetti L, Sportoletti P, Martelli MP. NPM1-mutated acute myeloid leukemia: from bench to bedside. Blood, The Journal of the American Society of Hematology. 2020; Oct 8; 136(15): 1707-21. https://doi.org/10.1182/blood.2019004226
4. Lewis EB. Leukemia and ionizing radiation. Science. 1957; May 17; 125(3255): 965-72. DOI: 10.1126/science.125.3255.965.
5. Zhang Y, Chen D, Shi R, Kamijima M, Sakai K, Tian Y, Gao Y. Indoor volatile organic compounds exposures and risk of childhood acute leukemia: a case-control study in shanghai. Journal of Environmental Science and Health, Part A. 2020; Dec 12; 56(2): 190-8. https://doi.org/10.1080/10934529.2020.1861903
6. Guan H, Miao H, Ma N, Lu W, Luo B. Correlations between Epstein‐Barr virus and acute leukemia. Journal of medical virology. 2017; 89(8): 1453-60. https://doi.org/10.1002/jmv.24797
7. Bükki J, Stanga Z, Tellez FB, Duclos K, Kolev M, Krähenmann P, Pabst T, Iff S, Jüni P. Omega-3 poly-unsaturated fatty acids for the prevention of severe neutropenic enterocolitis in patients with acute myeloid leukemia. Nutrition and cancer. 2013; Aug 1; 65(6): 834-42. https://doi.org/10.1080/01635581.2013.801998
8. Heck JE, Park AS, Qiu J, Cockburn M, Ritz B. Risk of leukemia in relation to exposure to ambient air toxics in pregnancy and early childhood. International journal of hygiene and environmental health. 2014; Jul 1; 217(6): 662-8. https://doi.org/10.1016/j.ijheh.2013.12.003
9. Tandon, S., Moulik, N.R., Kumar, A. et al. Effect of pre-treatment nutritional status, folate and vitamin B12 levels on induction chemotherapy in children with acute lymphoblastic leukemia. Indian Pediatr. 52, 385–389 (2015). https://doi.org/10.1007/s13312-015-0642-x
10. Roberts, A. (2021). Effects of Soy Isoflavone. The Science Journal of the Lander College of Arts and Sciences, 14(2), 17-23. https://touroscholar.touro.edu/sjlcas/vol14/iss2/4
11. Pettersen CH. The Effect of Omega-3 Polyunsaturated Fatty Acids on Human Cancer Cells:–Molecular Mechanisms Involved. http://hdl.handle.net/11250/263865
12. Rota M, Porta L, Pelucchi C, Negri E, Bagnardi V, Bellocco R, Corrao G, Boffetta P, La Vecchia C. Alcohol drinking and risk of leukemia—A systematic review and meta-analysis of the dose–risk relation. Cancer epidemiology. 2014; Aug 1; 38(4): 339-45. https://doi.org/10.1016/j.canep.2014.06.001
13. Savarese DM, Savy G, Vahdat L, Wischmeyer PE, Corey B. Prevention of chemotherapy and radiation toxicity with glutamine. Cancer Treatment Reviews. 2003; Dec 1; 29(6): 501-13. https://doi.org/10.1016/S0305-7372(03)00133-6
14. Yedjou CG, Rogers C, Brown E, Tchounwou PB. Differential effect of ascorbic acid and n‐acetyl‐l‐cysteine on arsenic trioxide‐mediated oxidative stress in human leukemia (HL‐60) Cells. Journal of Biochemical and Molecular Toxicology. 2008; Mar; 22(2): 85-92. https://doi.org/10.1002/jbt.20223
15. Barr RD, Gomez-Almaguer D, Jaime-Perez JC, Ruiz-Argüelles GJ. Importance of nutrition in the treatment of leukemia in children and adolescents. Archives of Medical Research. 2016; Nov 1; 47(8): 585-92. https://doi.org/10.1016/j.arcmed.2016.11.013
16. Reyna-Figueroa J, Barrón-Calvillo E, García-Parra C, Galindo-Delgado P, Contreras-Ochoa C, Lagunas-Martínez A, Campos-Romero FH, Silva-Estrada JA, Limón-Rojas AE. Probiotic supplementation decreases chemotherapy-induced gastrointestinal side effects in patients with acute leukemia. Journal of pediatric hematology/oncology. 2019; Aug 1; 41(6): 468-72. DOI: 10.1097/MPH.0000000000001497
17. Munir, A. H., and Khan, M. I. (2019). Pattern of Basic Hematological Parameters In Acute and Chronic Leukemias. Journal of Medical Sciences. 27(2), 125–129. Retrieved from https://jmedsci.com/index.php/Jmedsci/article/view/677
18. Barbosa K, Li S, Adams PD, Deshpande AJ. The role of TP53 in acute myeloid leukemia: challenges and opportunities. Genes, Chromosomes and Cancer. 2019; Dec; 58(12): 875-88. https://doi.org/10.1002/gcc.22796
19. Gilliland DG, Griffin JD. Role of FLT3 in leukemia. Current Opinion in Hematology. 2002; 9(4): 274-81. DOI: 10.1097/00062752-200207000-00003
20. Van Maele-Fabry, G., Duhayon, S. and Lison, D. A systematic review of myeloid leukemias and occupational pesticide exposure. Cancer Causes Control. 2007; 18: 457–478. https://doi.org/10.1007/s10552-007-0122-2