Author(s):
Novadri Ayubi, Nining Widyah Kusnanik, Lilik Herawati, Soni Sulistyarto, Anton Komaini, Muhammad Firman Halip, Ainun Zulfikar Rizki, Alvin Afandi, Mohammed Aljunaid, Aulia Putri Srie Wardani, Rais Firlando
Email(s):
novadriayubi@unesa.ac.id
DOI:
10.52711/0974-360X.2025.00708 
Address:
Novadri Ayubi1*, Nining Widyah Kusnanik1, Lilik Herawati2, Soni Sulistyarto1, Anton Komaini3, Muhammad Firman Halip1, Ainun Zulfikar Rizki1, Alvin Afandi1, Mohammed Aljunaid4, Aulia Putri Srie Wardani1, Rais Firlando1
1Universitas Negeri Surabaya, Surabaya, Indonesia.
2Universitas Airlangga, Surabaya, Indonesia.
3Universitas Negeri Padang, Padang, Indonesia.
4Taiz University, Taiz, Yemen.
*Corresponding Author
Published In:
Volume - 18,
Issue - 10,
Year - 2025
ABSTRACT:
The purpose of this study was to analyze and prove the effect of curcumin on TNF-a levels, and pain intensity after high-intensity physical exercise. This experimental research uses pre and post control group design. Research subjects were selected using random sampling technique. Next, the subjects were divided into 2 groups, K1 given placebo and K2 was given curcumin at a dose of 400 mg. A total of 20 healthy men participated in this study who were selected based on inclusion and exclusion criteria. On the first day, all subjects collected data on the characteristics of the research subjects, then did a warm-up, and then the subjects did physical exercises in the form of squad exercises and leg presses with an intensity of 80-90% of their maximum ability. Exercise is done 4 sets of each form of exercise and rest between sets of about 1 minute. The second day, after 24 hours post-exercise, all subjects measured pain intensity and took pre-test blood samples to measure TNF-a levels, then administer interventions based on each group. Pain intensity was measured using a VAS. On the third day, after 48 hours post-exercise, all subjects measured pain intensity and took post-test blood samples to measure TNF-a levels. The results of this study reported that the group that was given curcumin after high-intensity physical exercise was able to significantly reduce levels of TNF-a, and pain intensity (*p<0.05) compared to the placebo group. Giving a dose of 400 mg of curcumin after high-intensity physical exercise can reduce TNF-a levels and pain intensity after high-intensity physical exercise. Because reduction in pain intensity after high-intensity exercise is necessary to support body function, we recommend the use of curcumin for individuals who actively exercise. For future studies, we suggest testing the effects of curcumin on other inflammatory biomarkers.
Cite this article:
Novadri Ayubi, Nining Widyah Kusnanik, Lilik Herawati, Soni Sulistyarto, Anton Komaini, Muhammad Firman Halip, Ainun Zulfikar Rizki, Alvin Afandi, Mohammed Aljunaid, Aulia Putri Srie Wardani, Rais Firlando. Curcumin: A Compound in Turmeric That has the Potential to Reduce Tumor Necrosis Factor-Alpha (TNF-a) Levels, and Pain Intensity After High-Intensity Physical Exercise. Research Journal of Pharmacy and Technology. 2025;18(10):4909-4. doi: 10.52711/0974-360X.2025.00708
Cite(Electronic):
Novadri Ayubi, Nining Widyah Kusnanik, Lilik Herawati, Soni Sulistyarto, Anton Komaini, Muhammad Firman Halip, Ainun Zulfikar Rizki, Alvin Afandi, Mohammed Aljunaid, Aulia Putri Srie Wardani, Rais Firlando. Curcumin: A Compound in Turmeric That has the Potential to Reduce Tumor Necrosis Factor-Alpha (TNF-a) Levels, and Pain Intensity After High-Intensity Physical Exercise. Research Journal of Pharmacy and Technology. 2025;18(10):4909-4. doi: 10.52711/0974-360X.2025.00708 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-10-47
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