Author(s):
Irfan Irfan, Nusratuddin Abdullah, Nasrudin A Mappaware, Suryani As’ad, Syamsuri Syakri
Email(s):
irfandokter@yahoo.com
DOI:
10.52711/0974-360X.2025.00064
Address:
Irfan Irfan1*, Nusratuddin Abdullah2, Nasrudin A Mappaware3, Suryani As’ad4,6, Syamsuri Syakri5
1Doctoral Program, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia, 90245, Indonesia.
2Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Hasanuddin, Makassar, 90245, Indonesia.
3Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Muslim Indonesia, Makassar, 90231, Indonesia.
4Department of Nutrition, Faculty of Medicine, Universitas Hasanuddin, Makassar, 90245, Indonesia.
5Department of Pharmacy, Faculty of Medicine and Health Science, Universitas Islam Negeri Alauddin, Gowa, Indonesia.
6Medical Faculty and Health Science, Universitas Muhammadiyah Makassar, Makassar, Indonesia.
*Corresponding Author
Published In:
Volume - 18,
Issue - 1,
Year - 2025
ABSTRACT:
This literature review aims to provide a thorough study of many studies about Ajwa dates, including their nutritional makeup and the existence of advantageous compounds for health. Moreover, the aim of this literature research is to collect information on the relationship between the chemical makeup of Ajwa dates and the levels of the anti-mullerin hormone. Analysis of the PI3K/Akt/Foxo3a pathway showed that Quercetin decreased the phosphorylation of a protein that stimulates cyclophosphamide-induced follicular activation in the ovary. Moreover, Quercetin prevents cyclophosphamide-induced apoptosis in early-growing and antral follicles, maintains the Anti-Mullerian Hormone secreted by these follicles, and quiescence of the primordial follicle pool, as determined by intranuclear Foxo3a staining. It can be concluded that Quercetin in Ajwa Dates can attenuate cyclophosphamide-induced follicle loss by preventing phosphorylation of members of the PI3K/Akt/Foxo3a pathway and maintaining anti-Mullerian hormone levels through reducing apoptosis in growing follicles. Thus, Quercetin is expected to increase fertility We find that quercetin from Ajwa dates can inhibit PI3K/Akt/Foxo3a pathway members from becoming phosphorylated, which in turn can prevent cyclophosphamide-induced follicle loss. Additionally, quercetin can maintain anti-Mullerian hormone levels by lowering apoptosis in expanding follicles. Quercetin is therefore anticipated to boost fertility. The PI3K/Akt/Foxo3a pathway members' phosphorylation may be inhibited by quercetin from Ajwa dates, which can subsequently stop cyclophosphamide-induced follicle loss. Quercetin also reduces apoptosis in growing follicles, which helps to sustain anti-Mullerian hormone levels. Thus, quercetin is expected to increase fertility.
Cite this article:
Irfan Irfan, Nusratuddin Abdullah, Nasrudin A Mappaware, Suryani As’ad, Syamsuri Syakri. Effectiveness of the Nutritional Content and Bioactive Compounds of Ajwa Dates (Phoenix dactylifera L) against Anti-Mullerian Hormone (AMH) Levels: A Review. Research Journal of Pharmacy and Technology. 2025;18(1):415-0. doi: 10.52711/0974-360X.2025.00064
Cite(Electronic):
Irfan Irfan, Nusratuddin Abdullah, Nasrudin A Mappaware, Suryani As’ad, Syamsuri Syakri. Effectiveness of the Nutritional Content and Bioactive Compounds of Ajwa Dates (Phoenix dactylifera L) against Anti-Mullerian Hormone (AMH) Levels: A Review. Research Journal of Pharmacy and Technology. 2025;18(1):415-0. doi: 10.52711/0974-360X.2025.00064 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-1-64
REFERENCE
1. Srivastav Sanchit, Luhach Kanishk, Shukla Chhama, Yadav Rajender. Biologically active Pyrimidine Hydrazones. Asian J. Pharm. Res. 2015; 5(3): July- Sept., 162-165.
2. Shivani Sharma, Manpreet Rana, Hitesh Kumar , Bharat Parashar. It’s era to move towards nature for getting beneficial effects of plants having Antioxidant activity to fight against deleterious diseases. Asian J. Pharm. Res. 2013; 3(2): April- June 103-106.
3. Preeti Tiwari. Phenolics and Flavonoids and Antioxidant Potential of Balarishta Prepared by Traditional and Modern Methods. Asian J. Pharm. Ana. 2014; 4(1): Jan.-Mar. 05-10.
4. Rangarajan Narasimhan, Sathiyamoorthy. M. Phytochemical Screening and Antioxidant Studies in the Pulp Extracts of Cucurbita maxima. Asian J. Pharm. Res. 2016; 6(1): January -March, 01-04. doi: 10.5958/2231-5691.2016.00001.0
5. Abdel-Magied N, Ahmed AG, Abo Zid N. Possible ameliorative effect of aqueous extract of date (Phoenix dactylifera) pits in rats exposed to gamma radiation. Int J Rad Biol. 2018; 94: 815–824. doi: 10.1080/09553002.2018.1492165.
6. Nehdi IA, Sbihi HM, Tan CP, Rashid U, Al-Resayes SI. Chemical composition of date palm (Phoenix dactylifera L.) seed oil from six Saudi Arabian cultivars. J Food Sci. 2018; 83: 624–630. doi: 10.1111/1750-3841.14033
7. Zaid A, de Wet PF. Date palm cultivation. In: Zaid A, Arias Jiménez EJ, editors. Chapter II: Origin, geographical distribution and nutritional values of date palm, food and agriculture organization of the United Nations (FAO), plant production and protection. 1999. pp. 29–44.
8. Abdul-Hamid NA, Mediani A, Maulidiani M, Shadid K, Ismail IS, Abas F, Lajis NH. Metabolite characterization of different palm date varieties and the correlation with their NO inhibitory activity, texture and sweetness. J Food Sci Technol. 2018; 55: 1541– 1551. doi: 10.1007/s13197-018-3073-6.
9. Al Juhaimi F, Özcan MM, Adiamo OQ, Alsawmahi ON, Ghafoor K, Babiker EE. Effect of date varieties on physicochemical properties, fatty acid composition, tocopherol contents, and phenolic compounds of some date seed and oils. J Food Proc Preserv. 2018; 42: E13584. doi: 10.1111/jfpp.13584.
10. Al-Shahib W, Marshall RJ. The fruit of the date palm: it’s possible use as the best food for the future. Int J Food Sci Nutr. 2003; 54: 247–259. doi: 10.1080/09637480120091982.
11. Abu-Reidah IM, Gil-Izquierdo Á, Medina S, Ferreres F. Phenolic composition profiling of different edible parts and by-products of date palm (Phoenix dactylifera L.) by using HPLC-DAD-ESI/MSn. Food Res Int. 2017; Oct; 100(Pt 3): 494-500. doi: 10.1016/j.foodres.2016.10.018. Epub 2016 Oct 14. PMID: 28964373.
12. Ahmed A, Arshad MU, Saeed F, Ahmed RS, Chatha SA. Nutritional probing and HPLC profiling of roasted date pit powder. Pak J Nutr. 2016;15:229–237. doi: 10.3923/pjn.2016.229.237.
13. Khallouki F, Ricarte I, Breuer A, Owen RW. Characterization of phenolic compounds in mature Moroccan Medjool date palm fruits (Phoenix dactylifera) by HPLC-DAD- ESI-MS. J Food Compos Anal. 2018;70:63–71. doi: 10.1016/j.jfca.2018.03.005.
14. Alvi T, Khan MKI, Maan AA, Razzaq ZU. Date fruit as a promising source of functional carbohydrates and bioactive compounds: A review on its nutraceutical potential. J Food Biochem. 2022 Sep;46(9):e14325. doi: 10.1111/jfbc.14325. Epub 2022 Jul 27. PMID: 35894233.
15. Elguerrouj M, Paquot M, Robert C, Benjouad A, Bouakka M, Hakkou A. Physicochemical composition of two varieties of Moroccan palm date fruit. Asian J Chem. 2011; 23: 1932–1936.
16. Niazi S., Khan I., Pasha I., Rasheed S., Ahmad S., Shoaib M. Date Palm: Composition, Health Claim and Food Applications. Int. J. Pub. Health Health Sys. 2017; 2: 9–17
17. Shina S., Izuagie T., Shuaibu M., Dogoyaro A.I., Garba A., Abubakar S. The Nutritional Evaluation and Medicinal Value of Date Palm (Phoenix dactylifera) Int. J. Mod. Chem. 2013;4:147–154.
18. Ali H.S., Alhaj O.A., Al-Khalifa A.S., Brückner H. Determination and stereochemistry of proteinogenic and non-proteinogenic amino acids in Saudi Arabian date fruits. Amino Acids. 2014;46:2241–2257. doi: 10.1007/s00726-014-1770-7.
19. Hamad I, AbdElgawad H, Al Jaouni S, Zinta G, Asard H, Hassan S, Hegab M, Hagagy N, Selim S. Metabolic analysis of various date palm fruit (Phoenix dactylifera L.) cultivars from Saudi Arabia to assess their nutritional quality. Molecules. 2015; 20:13620–13641. doi: 10.3390/molecules200813620
20. Benmeddour Z, Mehinagic E, Meurlay DL, Louaileche H. Phenolic composition and antioxidant capacities of ten Algerian date (Phoenix dactylifera L.) cultivars: a comparative study. J Funct Foods. 2013; 5: 346–354. doi: 10.1016/j.jff.2012.11.005.
21. Ali BH, Bashir AK, Al-Hadrami G. Reproductive hormonal status of rats treated with date pits. Food Chem. 1999;66:437–441. doi: 10.1016/S0308-8146(98)00060-0.
22. Krishna Kondragunta. V, Karuppuraj. V, Perumal. K. Antioxidant activity and Folic acid content in indigenous isolates of Ganoderma lucidum. Asian J. Pharm. Ana. 2016; 6(4): 213-215.
23. Samundeeswari Mourougan, Gothainayagi A., G. Muthamilselvi. Assess the Effectiveness of PPT on Nurses attitude regarding significance of antioxidants in AVMC Hospital, Puducherry. Asian J. Nur. Edu. & Research 4(2): April- June 2014; Page 216-219.
24. Ben Abdallah F, Dammak I, Mallek Z, Attia H, Hentati B, Ammar- Keskes L. Effects of date seed oil on testicular antioxidant enzymes and epididymal sperm characteristics in male mice. Andrologia 2009; 41(4): 229-34.
25. Chandrasekaran M, Bahkali AH. Valorization of date palm (Phoenix dactylifera) fruit processing by-products and wastes using bioprocess technology—review. Saudi J Biol Sci. 2013;20:105–120. doi: 10.1016/j.sjbs.2012.12.004..
26. El-Kashlan AM, Nooh MM, Hassan WA, Rizk SM. Therapeutic potential of date palm pollen for testicular dysfunction induced by thyroid disorders in male rats. PLoS One 2015; 10(10): e0139493.
27. Elgasim EA, Alyousif YA, Homeida AM. Possible hormonal activity of date pits and flesh fed to meat animals. Food Chem. 1995;52:149–150. doi: 10.1016/0308- 8146(94)P4195-L.
28. El-Mougy SA, Abdel-Aziz SA, Al-Shanawany M, Omar A. The gonadotropic activity of Palmae in mature male rats. Alex J Pharm Sci. 1991;5:156–159.
29. Vayalil PK. Antioxidant and antimutagenic properties of aqueous extract of date fruit (Phoenix dactylifera L. Arecaceae) J Agric Food Chem. 2002;50:610–617. doi: 10.1021/jf010716t.
30. Elsadek B, El-Sayed ES, Mansour A, Elazab A. Abrogation of carbon tetrachloride- induced hepatotoxicity in Sprague-Dawley rats by Ajwa date fruit extract through ameliorating oxidative stress and apoptosis. Pak J Pharm Sci. 2017 Nov;30(6):2183- 2191. PMID: 29175788.
31. Khan TJ, Kuernan A, Razvi SS, Mehanna MG, Khan KA, Almulaiky YQ, Faidallah HM. In vivo evaluation of hypolipidemic and antioxidative effect of ‘Ajwa’ (Phoenix dactylifera L.) date seed-extract in high-fat diet-induced hyperlipidemic rat model. Biomed Pharmacother. 2018;107:675–680. doi: 10.1016/j.biopha.2018.07.134.
32. Jamil Z, Perveen K, Malik R, Avesi L. Predictive accuracy of anti mullerian hormone as indicator of ovarian follicle loss in cyclophosphamide treated mice. J Pak Med Assoc. 2017 Oct;67(10):1470-1475. PMID: 28955058.
33. Li J, Long H, Cong Y, Gao H, Lyu Q, Yu S, Kuang Y. Quercetin prevents primordial follicle loss via suppression of PI3K/Akt/Foxo3a pathway activation in cyclophosphamide-treated mice. Reprod Biol Endocrinol. 2021 Apr 23;19(1):63. doi: 10.1186/s12958-021-00743-y. PMID: 33892727; PMCID: PMC8063466.
34. Yang ZQ, Shao ZK, Chen HZ, Mao XR, Ma RM. Yang et al. Reply. Phys Rev Lett. 2021 Nov 12;127(20):209402. doi: 10.1103/PhysRevLett.127.209402. PMID: 34860064.
35. Mansouri A, Embarek G, Kokkalouc E, Kefalas P. Phenolic profile and antioxidant activity of the Algerian ripe date palm fruit (Phoenix dactylifera) Food Chem. 2005;89:411–420. doi: 10.1016/j.foodchem.2004.02.051.
36. Mehraban F, Jafari M, Akbartabar Toori M, Sadeghi H, Joodi B, Mostafazade M, Sadeghi H. Effects of date palm pollen (Phoenix dactylifera L.) and Astragalus ovinus on sperm parameters and sex hormones in adult male rats. Iran J Reprod Med 2014; 12(10): 705-
37. Niazi S., Khan I., Pasha I., Rasheed S., Ahmad S., Shoaib M. Date Palm: Composition, Health Claim and Food Applications. Int. J. Pub. Health Health Sys. 2017;2:9–17
38. Salem GA, Shaban A, Diab HA, Elsaghayer WA, Mjedib MD, Hnesh AM, Sahu RP. Phoenix dactylifera protects against oxidative stress and hepatic injury induced by paracetamol intoxication in rats. Biomed Pharmacother. 2018;104:366–374. doi: 10.1016/j.biopha.2018.05.049.
39. Qadir A, Shakeel F, Ali A, Faiyazuddin M. Phytotherapeutic potential and pharmaceutical impact of Phoenix dactylifera(date palm): current research and future prospects. J Food Sci Technol. 2020; Apr; 57(4): 1191-1204. doi: 10.1007/s13197-019- 04096-8. Epub 2019 Sep 14. PMID: 32180616; PMCID: PMC7054555.
40. Yang ZQ, Shao ZK, Chen HZ, Mao XR, Ma RM. Yang et al. Reply. Phys Rev Lett. 2021; Nov 12; 127(20): 209402. doi: 10.1103/PhysRevLett.127.209402. PMID: 34860064.
41. Preeti Tiwari, Rakesh K. Patel. Estimation of Total Phenolics and Flavonoids and Antioxidant Potential of Ashwagandharishta Prepared by Traditional and Modern Methods. Asian J. Pharm. Ana. 2013; 3(4): Oct. - Dec. 147-152.
42. Abdu SB. Ameliorative Influence of Ajwa Dates on Ochratoxin A-Induced Testis Toxicity. J Microsc Ultrastruct. 2018 Jul-Sep;6(3):134-138. doi: 10.4103/JMAU.JMAU_14_18. PMID: 30221139; PMCID: PMC6130239.
43. Muhammad Hamza Ashfaq, Amna Siddique, Sammia Shahid. Antioxidant Activity of Cinnamon zeylanicum: (A Review). Asian Journal of Pharmaceutical Research. 2021; 11(2): 106-6. doi: 10.52711/2231-5691.2021.0