Author(s):
Ranim Alrouhayyah, Nermin Dahma, Irena G Bratchikova
Email(s):
ranimalrouhayya@yahoo.com
DOI:
10.52711/0974-360X.2025.00054
Address:
Ranim Alrouhayyah1,2*, Nermin Dahma3, Irena G Bratchikova4
1Department of General Pharmaceutical and Biomedical Technology, Institute of Medicine, Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN University), 6 Miklukho-Maklaya street, Moscow, 117198, Russian Federation.
2Department of Analytical and Food Chemistry, Faculty of Pharmacy, Damascus University, Damascus, Syria.
3The Federal State Autonomous Educational Institution of Higher Education “Belgorod National Research University”, 308015 Belgorod, Pobedy street, 85, Russian Federation.
4Physical and Colloidal Chemistry Department, Faculty of Science, Peoples’ Friendship University of Russia Named after Patrice Lumumba (RUDN University),
6 Miklukho-Maklaya street, Moscow, 117198, Russian Federation.
*Corresponding Author
Published In:
Volume - 18,
Issue - 1,
Year - 2025
ABSTRACT:
This study aimed to evaluate the effect of some formulation and preparation variables (amount of hydrophobic polymer, amount and type of lubricant, compressive strength) on drug release from sustained- release domperidone matrix tablets prepared by wet granulation using ethylcellulose as a release-prolonging polymer. Drug release from the matrix tablets was studied in acidic medium (HCl 0.1 N) for the first 2 hours and then in phosphate buffer (pH=6.8) for the rest of the time (up to 24 hours), and the release kinetics were assessed using various mathematical models. It turned out that the total amount of drug released in acidic and phosphatic media decreases as the percentage of ethylcellulose or the compressive strength increases. Also, replacing a hydrophobic lubricant with a hydrophilic one or reducing the compressive strength increases the rate of dissolution. The release kinetics study showed that the drug was released from the prepared formulations according to Higuchi model, and the fit of the release data to Ritgger-Peppas model pointed to Fick's law of diffusion as the main release mechanism. The results of this study showed that ethylcellulose can be effectively used to prepare sustained-release domperidone matrix tablets, with the ability to prolong the release of the drug up to 24 hours by controlling not only the amount of polymer but also the compressive strength or lubricants.
Cite this article:
Ranim Alrouhayyah, Nermin Dahma, Irena G Bratchikova. A Study of the effect of some Formulation and Preparation variables on Drug Release from Matrix Tablets. Research Journal of Pharmacy and Technology. 2025;18(1):345-4. doi: 10.52711/0974-360X.2025.00054
Cite(Electronic):
Ranim Alrouhayyah, Nermin Dahma, Irena G Bratchikova. A Study of the effect of some Formulation and Preparation variables on Drug Release from Matrix Tablets. Research Journal of Pharmacy and Technology. 2025;18(1):345-4. doi: 10.52711/0974-360X.2025.00054 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-1-54
REFERENCES:
1. Kaur G, Arora M, Ravi Kumar MNV. Oral Drug Delivery Technologies-A Decade of Developments. J Pharmacol Exp Ther. 2019; 370(3): 529-543. doi: 10.1124/jpet.118.255828.
2. Pradeep N.Sh. A Review: Increasing Solubility of Poorly Soluble Drugs, by Solid Dispersion Technique. Research J. Pharm. and Tech. 2011; 4(12): 1933-1940.
3. Vilas A, Siddheshwar SS. A Review on Floating Microsphere. Asian J. Pharm. Tech. 2024; 14(1): 31-35. doi: 10.52711/2231-5713.2024.00007.
4. Rahul Kh, Nilkanth B, Nilesh K. A Review on Applications of Hydroxy Propyl Methyl Cellulose and Natural polymers for the development of modified release drug delivery systems. Research J. Pharm. and Tech. 2021; 14(2): 1163-1170. doi: 10.5958/0974-360X.2021.00208.0.
5. Parikshit P. A Review on Nanoparticle-Loaded Hydrogels for Extended Drug Release. Asian J. Pharm. Tech. 2024; 14(1): 55-8. doi: 10.52711/2231-5713.2024.00011
6. Madat DV, Gohel MC, Ramkishan A. Development of Venlafaxine Hydrochloride Controlled Release Pellets Prepared Employing the Blend of Ethyl Cellulose and Polyethylene Oxide. Research J. Pharm. and Tech. 2012; 5(10): 1289-1292.
7. Deo Sh. Modified Release drug delivery systems. Concept Pharma. 2017; DOI:10.13140/RG.2.2.30034.15046
8. Murugesan S, Gowramma B, Lakshmanan K, et al. Oral modified drug release solid dosage form with special reference to design; An Overview. Current Drug Research Reviews, 2020, 12: 16-25.
9. Songire PR, Aher SS, Saudagar RB. Recent Research on Matrix Tablets for Controlled Release – A Review. Asian J. Pharm. Tech. 2015; 5( 4): 214-221. doi: 10.5958/2231-5713.2015.00031.8.
10. Koutsamanis I, Paudel A, Nickisch K, et al. Controlled‐Release from High‐Loaded Reservoir‐Type Systems—A Case Study of Ethylene‐Vinyl Acetate and Progesterone. Pharmaceutics 2020; 12, 103; doi:10.3390/pharmaceutics12020103.
11. Huynh CT, Lee,DS. Controlled Release. In: Kobayashi, S., Müllen, K. (eds) Encyclopedia of Polymeric Nanomaterials. Springer, Berlin, Heidelberg. 2015; 439–449. https://doi.org/10.1007/978-3-642-29648-2_314.
12. Siegel RA, Rathbone MJ. Overview of controlled release mechanisms. In: Siepmann J, Siegel RA, Rathbone MJ (eds) Fundamentals and applications of controlled release drug delivery. Advances in delivery science and technology. Springer, New York. 2012; 19–43. https://doi.org/10.1007/978-1-4614-0881-9_2.
13. Bruneau M, Bennici S, Brendle J, et al. Systems for stimuli-controlled release: Materials and applications. J Control Release. 2019; 294: 355-371. doi: 10.1016/j.jconrel.2018.12.038.
14. Marturano V, Cerruti P, Giamberini M, Tylkowski B, Ambrogi V. Light-Responsive Polymer Micro- and Nano-Capsules. Polymers (Basel). 2016; 9(1): 8. doi: 10.3390/polym9010008.
15. Geraili A, Xing M, Mequanin K. Design and fabrication of drug-delivery systems toward adjustable release profiles for personalized treatment. VIEW. 2021; 2: 20200126. https://doi.org/10.1002/VIW.20200126.
16. Son G-H, Lee B-J, Cho Ch-W. Mechanisms of drug release from advanced drug formulations such as polymeric-based drug-delivery systems and lipid nanoparticles. Journal of pharmaceutical investigation. 2017; 47(6): 287-296.
17. Luke E A. Naresh P. Modelling of Drug Release from a Polymer Matrix System. Nov Appro Drug Des Dev. 2017; 2(3): 555589. DOI: 10.19080/NAPDD.2017.02.555589.
18. Kherud R, Sarode S. Review on Control Drug Delivery System. International Journal of Science and Research (IJSR). 2022; 11(3): 349-355. DOI: 10.21275/MR22307132546.
19. Kamel S, Ali N, Jahangir K, et al. pharmaceutical significance of cellulose: a review. Express Polymer Letters. 2008; 2(11): 758–778.
20. Katdare A, Chaubal MV. Excipient Development for Pharmaceutical, Biotechnology, and Drug Delivery Systems. Chapter 19: Polymeric Excipients for Controlled Release Applications. 2006, p.341.
21. Wasilewska K, Winnicka K. Ethylcellulose–a pharmaceutical excipient with multidirectional application in drug dosage forms development. Materials 2019; 12, 3386; doi:10.3390/ma12203386.
22. Trofimiuk M, Wasilewska K, Winnicka K. How to modify drug release in paediatric dosage forms? Novel technologies and modern approaches with regard to children’s population. Int. J. Mol. Sci. 2019, 20, 3200.
23. Avinash B, Suhas M K, Chirag VN, et al. Formulation and Evaluation of Mouth Dissolving Tablets of Domperidone. Research J. Pharm. and Tech. 2010; 3(3): 821-824.
24. Khan W, Siddique NF, Siddique J, et al. Formulation and Evaluation of Domperidone Sustained Release Tablet. Research J. Pharm. and Tech. 2018; 11(12): 5599-5610. doi: 10.5958/0974-360X.2018.01018.1.
25. Prajapati ST, Patel LD, Patel DM. Studies on Formulation and In Vitro Evaluation of Floating Matrix Tablets of Domperidone. Indian Journal of Pharmaceutical Sciences. 2009; 71(1): 19-23. DOI: 10.4103/0250-474X.51944.
26. Asif Khan M, Saeed M, Badshah A, et al. Design, formulation, optimization and evaluation of sustained release tablets of domperidone. African Journal of Pharmacy and Pharmacology. 2011; 5(16): 1882-1887,
27. Mor J, Kumar N. Formulation and evaluation of extended release tablets of domperidone. Pharma Research. 2013; 10(1): 75-83.
28. Patil HG, Tiwari RV, Repka MA, et al. Formulation and development of orodispersible sustained release tablet of domperidone. Drug Development and Industrial Pharmacy. 2015; 42(6): 906–915. https://doi.org/10.3109/03639045.2015.1088864.
29. Olorunsola EO, Majekodunmi SO. Development of extended-release formulation of domperidone using a blend of Raphia hookeri gum and hydroxypropyl methylcellulose as tablet matrix. Tropical Journal of Pharmaceutical Research. 2017; 16 (10): 2341-2347.
30. Kumar R, Tripathi A. Formulation, Development and Optimization of Floating Sustain Release Tablets of Domperidone for the Effective Treatment of Antiemetic During Chemotherapy. IJIRT. 2021; 8(7): 451-456.
31. State Pharmacopoeia of the Russian Federation. XV ed. (2023). Moscow. URL: https://pharmacopoeia.regmed.ru/pharmacopoeia/izdanie-15/. (accessed 10.07.2024). (In Russ.)
32. Tousey M. D. Pharmaceutical technology tableting and granulation; The Granulation Process 101- Basic Technologies For Tablet Making. 2002; 8-13.
33. Patel AJ, Singh RP, Patel V. Goswami Sh. Application of Mathematical Models in Drug Release Kinetics of Lagerstroemia Speciosa Extract-Phospholipid Complex. Research J. Pharm. and Tech. 2022; 15(3):1257-2. doi: 10.52711/0974-360X.2022.00210.
34. Alrouhayya R, Sheshko TF, Markova EB, et al. Study of Dissolution Kinetics of Mefenamic Acid Solid Dispersion with Polyvinylpyrrolidone. Herald of the Bauman Moscow State Technical University, Series Natural Sciences. 2021; 6( 99 ): 79-95 (in Russ.) DOI: https://doi.org/10.18698/1812-3368-2021-6-79-95.
35. Salome Ch ,Godswill O, Ikechukwu O. Kinetics and Mechanisms of Drug Release from Swellable and Non Swellable Matrices: A Review. Research Journal of Pharmaceutical Biological and Chemical Sciences. 2013; 4(2): 97-103.
36. The International pharmacopeia, 11th edition, 2022
37. Mishra A, Yadav SK. Development of sustained release metoprolol succinate matrix tablets using kappa carrageenan as monolithic polymer. Research J. Pharm. and Tech. 2016; 9(9):1311-1316. doi: DOI: 10.5958/0974-360X.2016.00249.3.
38. Alrouhayyah R, Sheshko TF, Suslina SN. Improving the Dissolution rate of Mefenamic acid by preparing Solid Dispersions with Polyethylene glycol 4000. Research J. Pharm. and Tech. 2023; 16(7): 3115-9. doi: 10.52711/0974-360X.2023.00512.