Author(s): M. Shofwan Haris, Aniek Setiya Budiatin, Mahardian Rahmadi, Toetik Aryani, Melisa Ramadhaniar

Email(s): aniek-s-b@ff.unair.ac.id

DOI: 10.52711/0974-360X.2025.00051   

Address: M. Shofwan Haris1, Aniek Setiya Budiatin2*, Mahardian Rahmadi2, Toetik Aryani2, Melisa Ramadhaniar2
1Master of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, Indonesia.
2Department of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, Indonesia.
*Corresponding Author

Published In:   Volume - 18,      Issue - 1,     Year - 2025


ABSTRACT:
Bone defects resulted from fractures caused by vehicle accidents, falls, heavy object impacts, or acts of violence. Bone grafting is one of treatment method of bone defects. This study aims to investigate the impact of gelatin: CaSO4 concentration variation on nano BHA-Gelatin-CaSO4 composite pellets. Nano BHA constitutes a fixed concentration of 51.5% in each formula, with gelatin:CaSO4 concentrations of 10:38.5, 15:33.5, and 20:28.5 (in percentage). Compressive strength was measured using an autograph, while degradation tests were conducted by immersing pellets in pH 7.4 PBS. Morphology, pore size, and Ca/P ratio were observed using SEM-EDX. Results revealed that the compressive strength of pellets in formula 1, formula 2, and formula 3 were respectively 1.82±0.02 MPa, 2.21±0.06 MPa, and 2.35±0.03 MPa (p=0.000). Weight reduction percentages in the degradation test for formula 1, formula 2, and formula 3 were respectively 24.60±0.73%, 32.18±0.34%, and 100.0% (p=0.012). Average pore sizes produced in formula 1, formula 2, and formula 3 were respectively 1.25± 0.03µm, 1.06±02µm, and 0.95±0.10µm (p=0.002). EDX analysis of BHA-gelatin-CaSO4 nano pellets detected C, O, Mg, P, S, and Ca elements, with Ca/P ratios of 4.24, 4.10, and 4.06, respectively. In conclusion, variations in gelatin:CaSO4 concentration affects the compressive strength test, degradation test, and the resulting pore size.


Cite this article:
M. Shofwan Haris, Aniek Setiya Budiatin, Mahardian Rahmadi, Toetik Aryani, Melisa Ramadhaniar. Fabrication and Characterization of Bone Graft Nano Bovine Hydroxyapatite-Gelatine-Calcium Sulfate: A Top-Down approach for a Natural Biomaterial. Research Journal of Pharmacy and Technology. 2025;18(1):326-2. doi: 10.52711/0974-360X.2025.00051

Cite(Electronic):
M. Shofwan Haris, Aniek Setiya Budiatin, Mahardian Rahmadi, Toetik Aryani, Melisa Ramadhaniar. Fabrication and Characterization of Bone Graft Nano Bovine Hydroxyapatite-Gelatine-Calcium Sulfate: A Top-Down approach for a Natural Biomaterial. Research Journal of Pharmacy and Technology. 2025;18(1):326-2. doi: 10.52711/0974-360X.2025.00051   Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-1-51


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