Author(s): Kiran C. Mahajan, Komal G. Nirale, Ganesh Y. Dama, Poonam Bramhane, Ashwini S. Gawade

Email(s): kirancmahajan@gmail.com

DOI: 10.52711/0974-360X.2025.00035   

Address: Kiran C. Mahajan1*, Komal G. Nirale2, Ganesh Y. Dama3, Poonam Bramhane4, Ashwini S. Gawade5
SGMSPM’s Sharadchandra Pawar College of Pharmacy, At – Dumberwadi, Post - Otur, Tal – Junnar, District - Pune Maharashtra 412409.
*Corresponding Author

Published In:   Volume - 18,      Issue - 1,     Year - 2025


ABSTRACT:
Background: Schistosomiasis is a medical condition triggered by blood worms that infect several organs, including the colon, bladder, liver and urethra. There are 5 species capable of infecting humans. The three most frequent strains are S. haematobium, S. japonicum, and S. mansoni. Objective: The preferred medication for treating human fluke infections like schistosomiasis is praziquantel (PZQ). Method: To choose the best component combination, the solubility of the PZQ was calculated in a variety of solvents. Smix ratios 1:1, 2:1, and 3:1 was chosen for 9 formulations containing oleic acid. Result: The improved formulation F5 has a 98.02% transmittance, a cloud point of 85.3°C and the globule size of formulation was found to be 282.7nm which enhance the penetration efficiency of drug. Conclusion: Outcomes suggest that PZQ-loaded SMEDDS exhibited improved solubilization and potential to promote medication absorption.


Cite this article:
Kiran C. Mahajan, Komal G. Nirale, Ganesh Y. Dama, Poonam Bramhane, Ashwini S. Gawade. Emerging Implementation of Praziquantel Drug Loaded with Self-Micro Emulsifying Drug Delivery System to Enhance the Antischistosomal Efficacy. Research Journal of Pharmacy and Technology. 2025;18(1):227-1. doi: 10.52711/0974-360X.2025.00035

Cite(Electronic):
Kiran C. Mahajan, Komal G. Nirale, Ganesh Y. Dama, Poonam Bramhane, Ashwini S. Gawade. Emerging Implementation of Praziquantel Drug Loaded with Self-Micro Emulsifying Drug Delivery System to Enhance the Antischistosomal Efficacy. Research Journal of Pharmacy and Technology. 2025;18(1):227-1. doi: 10.52711/0974-360X.2025.00035   Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-1-35


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