Author(s):
Mrunmayee P. Toraskar, Ashwini H. Rewale, Kajal T. Kharat
Email(s):
mrunmayee.toraskar@bvcop.in , ashwini.rewale@gmail.com , kajalkharat2350@gmail.com
DOI:
10.52711/0974-360X.2025.00031 
Address:
Mrunmayee P. Toraskar*, Ashwini H. Rewale, Kajal T. Kharat
Department of Pharmaceutical Chemistry, Bharati Vidyapeeth’s College of Pharmacy, CBD Belapur, Navi Mumbai – 400614, Maharashtra, India.
*Corresponding Author
Published In:
Volume - 18,
Issue - 1,
Year - 2025
ABSTRACT:
A series of pyrazoline analogues (4a-4h) prepared from respective dibenzylideneacetones, (3a-3h) was studied as potential anticancer agents. Dibenzylideneacetone analogues were synthesized from acetone and excess moles of aromatic/heteroaromatic aldehydes, which were further cyclized into pyrazolines with the help of hydrazine in the presence of formaldehyde. In-vitro anti-cancer activity was performed against thehuman breast cancer cell line (MCF7) by using MTT assay. The compound 4b [5-(4-fluorophenyl)-3-[(E)-2-(4-fluorophenyl) ethenyl]-4,5-dihydro-1H-pyrazole-1- carbaldehyde] and compound 4d [5-(4-methylphenyl)-3-[(E)-2-(4-methylphenyl) ethenyl]-4,5-dihydro-1H-pyrazole-1- carbaldehyde] were found to be the moderately active with IC50 of 38.49±0.17µM and 35.49±2.44 µM respectively. The molecular docking studies were conducted forthe newly synthesized molecules with the AutoDock 4.2.6 docking program. All eight derivatives were determined by the EGFR receptor (PDB ID 1M17) active binding domain, with binding energies ranging from -7.4 to -9.27 Kcal/mol.
Cite this article:
Mrunmayee P. Toraskar, Ashwini H. Rewale, Kajal T. Kharat. ADMET Properties, Bioactivity and Molecular Docking Studies of newly synthesized 5-(substituted phenyl)-3-(2(substituted) ethenyl-4,5-dihydro-1 H-pyrazole-1-carbaldehyde derivatives. Research Journal of Pharmacy and Technology. 2025;18(1):203-1. doi: 10.52711/0974-360X.2025.00031
Cite(Electronic):
Mrunmayee P. Toraskar, Ashwini H. Rewale, Kajal T. Kharat. ADMET Properties, Bioactivity and Molecular Docking Studies of newly synthesized 5-(substituted phenyl)-3-(2(substituted) ethenyl-4,5-dihydro-1 H-pyrazole-1-carbaldehyde derivatives. Research Journal of Pharmacy and Technology. 2025;18(1):203-1. doi: 10.52711/0974-360X.2025.00031 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-1-31
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