Author(s):
Bharathi Arigela, D. Chandra Sekhar Naik, Kovida Chanumolu, Yamini Durga Talaparthi
Email(s):
bharathi.arigela004@gmail.com
DOI:
10.52711/0974-360X.2025.00026
Address:
Bharathi Arigela1*, D. Chandra Sekhar Naik2, Kovida Chanumolu3, Yamini Durga Talaparthi3
1Professor, Department of Pharmaceutics and Biotechnology, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, Andhra Pradesh, India.
2Professor, Department of Pharmaceutics, Nimra College of Pharmacy, Vijayawada, Andhra Pradesh, India.
3Students, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, Andhra Pradesh, India.
*Corresponding Author
Published In:
Volume - 18,
Issue - 1,
Year - 2025
ABSTRACT:
Ocimum gratissimum mucilage isolated from Ocimum gratissimum seeds at raised temperatures was a white crystalline powder. The modified mucilage derived from Ocimum gratissimum exhibits remarkable flow properties and exhibits insolubility in water and aqueous solutions across a range of alkaline and acidic buffers. It likewise showed excellent water edema (90%) as well. When cooked to 100°C for 30 minutes in water, it does not gel. It was tested as a disintegrant in tablet forms and is thought to be a promising disintegrant. Telmisartan tablets were tested after being manufactured using a direct compression method with 0-10% Ocimum Gratissimum mucilage as a novel super disintegrant. The level of independent factors (sodium starch glycolate, croscarmellose sodium, and Ocimum Gratissimum mucilage) on dependent variables (disintegration time, water absorption, wetting time, and percent release in 5 minutes) in the formulations were optimised using a 2x3 factorial design. After that, the enhanced recipe was press-coated in various ratios with naturally occurring time-released polymers such Gardenia Gummifera and Anogeissus latifolia gum. Based on post-compression properties, the best formulation was selected, and dissolution data underwent three months of accelerated stability testing of the ten coating formulations. Impressive outcomes were observed with F2CC6, with a maximum cumulative medication release of 99.54% in a 12hour period. Due to its release pattern and capacity to administer the medication at the proper time, location, and dosage, the suggested delivery technique exhibits significant promise for hypertensive patients.
Cite this article:
Bharathi Arigela, D. Chandra Sekhar Naik, Kovida Chanumolu, Yamini Durga Talaparthi. Pharmacokinetic Evaluation of Telmisartan Chronotherapeutic Press Coated Tablets. Research Journal of Pharmacy and Technology. 2025;18(1):173-6. doi: 10.52711/0974-360X.2025.00026
Cite(Electronic):
Bharathi Arigela, D. Chandra Sekhar Naik, Kovida Chanumolu, Yamini Durga Talaparthi. Pharmacokinetic Evaluation of Telmisartan Chronotherapeutic Press Coated Tablets. Research Journal of Pharmacy and Technology. 2025;18(1):173-6. doi: 10.52711/0974-360X.2025.00026 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-1-26
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