Author(s):
Seba Mawafak, Shn Bashar Zainulabdeen, Kais A Najem, Amal Mayyas, Amjad I Oraibi, Zahraa Salam Al-Tameemi, Hany A. Al-hussaniy, Fatima Akeel naji, Ali Hikmat Alburghaif, Mohammed K. Al iraqi, Meena akeel Naji
Email(s):
hanyakeel2018@gmail.com
DOI:
10.52711/0974-360X.2024.00712
Address:
Seba Mawafak1, Shn Bashar Zainulabdeen2, Kais A Najem3, Amal Mayyas4, Amjad I Oraibi5, Zahraa Salam Al-Tameemi6, Hany A. Al-hussaniy6*, Fatima Akeel naji6, Ali Hikmat Alburghaif7, Mohammed K. Al iraqi6, Meena akeel Naji6
1Department Family Medicine, College of Medicine, Baghdad, Iraq.
2Pharmacy Department, Al-Karkh Baghdad Health Department, Ministry of Health Iraq.
3Department of clinical Pharmacy, College of Pharmacy , Univeristy of Baghdad, Iraq.
4Department of Pharmacy, Faculty of Health Sciences, American University of Madaba, Madaba, 11821, Jordan.
5Al-Manara College for Medical Sciences, Department of Pharmacy, Amarah, Iraq.
6 Dr Hany Akeel Institute, Iraqi Medical Research Center, Baghdad, 10001, Iraq.
7Department of pharmaceutical chemistry , Ibn Sina University of Medical and Pharmaceutical Sciences, Baghdad, Iraq.
*Corresponding Author
Published In:
Volume - 17,
Issue - 9,
Year - 2024
ABSTRACT:
Background: Uncontrolled hypertension increases the risk of cardiovascular illnesses and death, among other serious health problems. There are antihypertensive medications available, yet some individuals still don't respond to them. Because of the critical function that adrenaline neurons play in blood pressure control, inhibiting these neurons may offer a treatment option for resistant hypertension. Aim: This study conducted to Evaluation of the Efficacy of nanotecology based therapy as Adrenergic Neurons Inhibition in Patients with Uncontrolled Hypertension. Method: We was conducted a review article in the role of adrenergic blocker by medication or by surgery, knowing that we was used keywords "Antihypertensive Agents" and "nanotechnology based therapy," , "Adrenergic Neurons" , "Ganglia", "Spinal" and "Hypertensive Crisis" . in relevant search Engine such as google scholar , ResearchGate, PubMed and so one, we exclude any not relevant article and hypertention in pregnancy and so one. Result: The nanotechnology-enhanced treatment group showed a significant reduction in systolic and diastolic blood pressure compared to the control group. On average, the treatment group experienced a 20% greater reduction in blood pressure levels. Additionally, patients reported fewer side effects and better overall tolerance to the treatment. Conclusion: Nanotechnology-enhanced adrenergic neuron inhibition demonstrates substantial promise in managing uncontrolled hypertension. The improved efficacy and reduced side effects suggest that this innovative approach could offer a viable alternative for patients who do not respond well to conventional therapies. Further research and larger clinical trials are warranted to confirm these findings and optimize the treatment protocol.
Cite this article:
Seba Mawafak, Shn Bashar Zainulabdeen, Kais A Najem, Amal Mayyas, Amjad I Oraibi, Zahraa Salam Al-Tameemi, Hany A. Al-hussaniy, Fatima Akeel naji, Ali Hikmat Alburghaif, Mohammed K. Al iraqi, Meena akeel Naji. Evaluation of Adrenergic Neuron Inhibition in Patients with Uncontrolled Hypertension. Research Journal of Pharmacy and Technology. 2024; 17(9):4613-0. doi: 10.52711/0974-360X.2024.00712
Cite(Electronic):
Seba Mawafak, Shn Bashar Zainulabdeen, Kais A Najem, Amal Mayyas, Amjad I Oraibi, Zahraa Salam Al-Tameemi, Hany A. Al-hussaniy, Fatima Akeel naji, Ali Hikmat Alburghaif, Mohammed K. Al iraqi, Meena akeel Naji. Evaluation of Adrenergic Neuron Inhibition in Patients with Uncontrolled Hypertension. Research Journal of Pharmacy and Technology. 2024; 17(9):4613-0. doi: 10.52711/0974-360X.2024.00712 Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-9-73
REFERENCES:
1. Sharp ASP, Sanderson A, Hansell N, Reddish K, Miller P, Moss J, et al. Renal denervation for uncontrolled hypertension: a systematic review and meta-analysis examining multiple subgroups. J Hypertens. 2024; 42(7): 1133–44. DOI:10.1097/HJH.0000000000003727
2. Liu X, Nianogo RA, Janzen C, Fei Z, Seamans MJ, Wen R, et al. Association between gestational diabetes mellitus and hypertension: A systematic review and meta-analysis of cohort studies with a quantitative bias analysis of uncontrolled confounding. Hypertension. 2024; 81(6): 1257–68. DOI:10.1161/hypertensionaha.123.22418
3. Biffi A, Quarti-Trevano F, Vanoli J, Dell’Oro R, Corrao G, Mancia G, et al. Effects of acute carotid baroreceptor stimulation on sympathetic nerve traffic in resistant and uncontrolled hypertension: a systematic review and meta-analysis. Hypertens Res. 2024; DOI:10.1038/s41440-024-01704-9
4. Al-Hussaniy HA, Alburghaif AH, AL-Zobaidy MA, Alkuraishy HM, Mostafa-Hedeab G, Azam F, Al-Samydai AM, Al-tameemi ZS, Naji MA. Chemotherapy-induced cardiotoxicity: a new perspective on the role of Digoxin, ATG7 activators, Resveratrol, and herbal drugs. Journal of Medicine and Life. 2023; 16(4): 49 DOI: 10.25122/jml-2022-0322
5. Thomopoulos C, Hitij JB, De Backer T, Gkaliagkousi E, Kreutz R, Lopez-Sublet M, et al. Management of hypertensive disorders in pregnancy: a Position Statement of the European Society of Hypertension Working Group Hypertension in Women. J Hypertens. 2024; 42(7): 1109–32. DOI:10.1097/HJH.0000000000003739
6. Stevanovic A, Dwklwva M, Smiljic S, Popovic BP. Clinical, laboratory and echocardiographic variables associated with uncontrolled resistant hypertension in women. J Hypertens. 2024; 42(Suppl 1): e311–2. DOI:10.1097/01.hjh.0001022740.03975.85
7. Alzobaidy MA, Alburghaif AH, Alhasany HA, Naji MA. Angiotensin-converting enzyme inhibitors may increase risk of severe COVID-19 infection. Annals of the Romanian Society for Cell Biology. 2021; 25(6): 17843–9.
8. Al-kuraishy AA, Jalil HJ, Mahdi AS, Al-hussaniy H. General anesthesia in patient with Brain Injury. Medical and Pharmaceutical Journal. 2022; 1(1): 25-34.
9. Hamsund IRB, Waldum - Grevbo B, H⊘ieggen A, Amro A, Olsvold N, Halvorsen LV. A direct comparison of two objective methods for detection of non-adherence in patients with uncontrolled hypertension. J Hypertens. 2024; 42(Suppl 1): e61–2. DOI:10.1097/01.hjh.0001019856.66225.b7
10. Zhu A, Ostbye T, Naheed A, de Silva HA, Jehan I, Gandhi M, et al. Ambulatory blood pressure levels in individuals with uncontrolled clinic hypertension across Bangladesh, Pakistan, and Sri Lanka. J Clin Hypertens (Greenwich). 2024; 26(4): 391–404. DOI:10.1111/jch.14787
11. Naji MA, Alburghaif AH, Saleh NK, Al-hussaniy HA. Patient expectations regarding consultation with a family doctor: a cross-sectional study. Med Pharm J. 2022; 1(1): 35–40. DOI:/10.55940/medphar20225
12. Shukurova D, Khamidullayeva G, Abdullaeva G, Yusupova H. Comparative effectiveness of free and fixed combined antihypertensive therapy in achieving target blood pressure values in uncontrolled arterial hypertension. J Hypertens. 2024; 42(Suppl1): e109. DOI:10.1097/01.hjh.0001020404.63757.86
13. Galli V, Trento L, Salfa F, Fezzi S, Trevisanello A, Galuppi E, et al. Long-term clinical outcome of physiology-guided renal artery stenting with zetarolimus eluting stents in patients with uncontrolled renovascular hypertension. J Hypertens. 2024; 42 (Suppl 1): e52. DOI:10.1097/01.hjh.0001019756.67401.97
14. Mahfoud F, Townsend RR, Mancia G, Kandzari DE, Whitbourn R, Bhatt DL, et al. Pooled, long-term analysis of the Global Symplicity Clinical trial program of radiofrequency renal denervation for the treatment of uncontrolled hypertension. J Hypertens. 2024; 42(Suppl 1): e17. DOI:10.1097/01.hjh.0001019468.65470.8a
15. Hiura GT, Markossian TW, Probst BD, Tootooni MS, Wozniak G, Rakotz M, et al. Age and comorbidities are associated with therapeutic inertia among older adults with uncontrolled blood pressure. Am J Hypertens. 2024; 37(4): 280–9. DOI:10.1093/ajh/hpad108
16. Ahmed, M.S., Reyadh, A.R., Shareef, B.Q., Ali, A.R.H., Hany, A.H.A. and Meena, A.N. Increasing Prevalence of Congenital Hypothyroidism in children with Down Syndrome who have a family history of Thyroid disease. Research Journal of Pharmacy and Technology. 2023; 16(3): 1327-1332.
17. Gasmi M, Hooker RW, Maaouia GB, Chikhad AB. The effects of intermittent fasting on markers of health: A narrative review. Medical and Pharmaceutical Journal. 2023; 2(2): 121-33.
18. Zhu Q, Huo Z, Zeng F, Gong N, Ye P, Pan J, et al. Apparent treatment-resistant hypertension in the first year associated with cardiovascular mortality in peritoneal dialysis patients. Am J Hypertens. 2024; 37(7): 514–22. DOI:10.1093/ajh/hpae010
19. Beshna EA, Alahrish RA. Pharmacists' knowledge and attitudes toward Pharmacogenomics in Zawia, Libya. Medical and Pharmaceutical Journal. 2023; 2(3): 158-66.
20. Mwesigwa N, Shibao CA. Norepinephrine reuptake inhibition, an emergent treatment for neurogenic orthostatic hypotension. Hypertension. 2024; 81(7): 1460–6. Available from: http://dx.doi.org/10.1161/hypertensionaha.124.22069
21. Nowicki J, Silka W, Zalustowicz A, Rajzer M, Olszanecka A. Uncontrolled hypertension and hypertensive urgency – one year single center Emergency Department experience. J Hypertens. 2024; 42(Suppl 1): e240. Available from: http://dx.doi.org/10.1097/01.hjh.0001021936.09613.26
22. Sartorio A, Romano S, Rigon G, Albrigi M, Tebaldi G, Cristin L, et al. Hypertension, uncontrolled hypertension and resistant hypertension: Prevalence, comorbidities and prescribed medications in 228,406 adults resident in urban areas. A population-Bas. J Hypertens. 2024; 42(Suppl 1):e23. Available from: http://dx.doi.org/10.1097/01.hjh.0001019508.27032.29
23. Kazuomi K, Mahfoud F, Townsend R, Kandzari DE, Weber MA, Schmieder RE, et al. Significant nighttime blood pressure reductions after radiofrequency renal denervation in patients with uncontrolled hypertension: Pooled analysis of the Spyral htn trials. J Hypertens. 2024; 42(Suppl 1): e137–8. DOI:10.1097/01.hjh.0001020724.36596.7d
24. Messerli FH, Schoenenberger-Berzins R, Messerli AW. Why the lack of enthusiasm for renal denervation? J Hypertens. 2024; 42(7): 1145–6. Available from: http://dx.doi.org/10.1097/HJH.0000000000003731
25. Schlaich M, Mahfoud F, Narkiewicz K, Ruilope L, Williams B, Schmieder RE, et al. Three-year nighttime blood pressure reductions after radiofrequency renal denervation in patients with uncontrolled hypertension and chronic kidney disease. J Hypertens. 2024; 42(Suppl 1): e18. DOI:10.1097/01.hjh.0001019476.46004.16
26. Salim Mahmood A, Ammoo AM, Ali MH, Hameed TM, Al-Hussaniy HA, Aljumaili AA, Al-Fallooji MH, Kadhim AH. Antiepileptic Effect of Neuroaid® on Strychnine-Induced Convulsions in Mice. Pharmaceuticals. 2022; 15(12): 1468.
27. Awad M, Al-Hussaniy HA, Alburghaif AH, Tawfeeq KT. The role of COVID-19 in myopathy: incidence, causes, treatment, and prevention. Journal of Medicine and Life. 2022 Dec;15(12):1458.
28. Goodman J, Kulkarni S, Selvarajah V, Hilliard N, Russell N, Wilkinson IB. Renal autotransplantation for uncontrolled hypertension in nonatherosclerotic renal artery stenosis-2 case reports and a brief review of the literature. Hypertension. 2024; 81(4): 669–75. DOI: 10.1161/HYPERTENSIONAHA.123.19878
29. Abdulhamza HM, Farhan MS, Hassan SS, Al-Hussainy HA, Oriabi AI. In silico identification of antiviral compounds for the treatment of chikungunya virus infection: qsar modelling and md simulation analysis. Medicine in Novel Technology and Devices. 2024 ;22:100304.
30. Al-Hussaniy HA, Hassan AF, Oraibi AI, Al-Juhaishi AM, Naji FA, Al-Tameemi ZS. Clinical Pharmacogenetics of Angiotensin II Receptor Blockers in Iraq. Journal of Pharmacy and Bioallied Sciences. 2023; 15(3): 101-6.
31. Al-Hussaniy HA, Al-kuraishy AA, Jalil HJ. Evaluation of the efficacy of adrenergic neurons inhibition through various surgical and therapeutic regimens on controlling blood pressure and circadian rhythm in patients with uncontrolled hypertension. Journal of Clinical Trials and Experimental Investigations. 2022;1(3):106-13.
32. Al_hussaniy HA, Alkhafaje Z, Altamimi ZS, Oraibi AI, Abdalhassan AH, Abdulhamza HM, AL-Zobaidy MJ. Memantine and its role in parkinsonism, seizure, depression, migraine headache, and Alzheimer’s disease. Pharmacia. 2023; 70(2): 291-7.
33. Shawaludin MQA, Hussain S, Yaacob NM. Prevalence and Risk Factors for Dyslipidaemia and Hypertension in Diabetes Mellitus among Paediatric Population in Hospital Universiti Sains Malaysia (USM). Journal of Medicine and Health Sciences. 2024; 20: 66–72.
34. Elias NIM, Malaysian SM. Prevalence of Hypertension and Its Determinant Factors among Workers at Port Container Terminal Daud. Journal of Medicine and Health Sciences. 2023; 19:71–79
35. Muhammad A, Halim A, Azwal N. Ortner's Syndrome With Primary Pulmonary Hypertension-A Case Report. Malaysian Journal of Medicine and Health Sciences. 2023; 65(3): 1775–1786
36. Al-Hussaniy HA, Аlmajidi YQ, Oraibi AI, Alkarawi AН. Nanoemulsions as medicinal components in insoluble medicines. Pharmacia. 2023; 70(3): 537-47.
37. Malek M, Hosseini A, Moradi B, Rahmani M, Aghasi M, Akhavan S, Ahmadinejad N, Abdolghafoorian H. Pattern Recognition or Adnexal MR Scoring System: Which Is More Accurate in Evaluating Adnexal Lesions?. Asian Pacific Journal of Cancer Prevention. 2024; 25(4): 1265.
38. Al-hussaniy HA, Al-Shammari AH, Sameer HN, Oraibi AI. The relationship between statin therapy and adipocytokine/inflammatory mediators in dyslipidemic nondiabetic patients: A comparative study. Pharmacia. 2023; 70(3): 581-5.
39. Hussein HA, Goreal AA. SARS-CoV2 Viral Ct Values Correlation with Some Patients’ Factors and Disease Outcome. Iraqi Journal of Science. 2024; 65(3): 1230-8.
40. Al-Zwaini H, Hatem Al-Mugdadi SF, Kareem Abbas WA. Detection of FOXP-3 Expression in a Sample of Iraqi Cervical Cancer Patients Using Immunohistochemistry Technique. Iraqi Journal of Science. 2022; 63(12): 5106-5118.
41. Sheashea AA, Ahmed FA, El Zayat E, Ebeed BW, Elberry MH, Hassan ZK, Hafez MM. In Vitro Antiviral and Anticancer Effects of Tanacetum sinaicum Essential Oil on Human Cervical and Breast Cancer. Asian Pacific Journal of Cancer Prevention. 2024; 25(4): 1457.
42. Xu Y, Zai W, Yang M, Zhu L, Zhang Y, Fu X, Dai T. Influence of intelligent management mode based on Internet of Things on self-management ability and prognosis of elderly patients with hypertensive heart disease: An observational study. Medicine. 2024; 103(22): e38179.
43. Al Haddad M, El-Mezayen HA, El-Kassas M, Metwally F, El-Sharkawy A. Clinical Utility of Cytokeratins for Accurate Diagnosis of Hepatocellular Carcinoma Among Hepatitis C Virus High-Risk Patients. Asian Pacific Journal of Cancer Prevention. 2024; 25(4): 1325.
44. Wang S, Xue Z, Su D, Ji L, Gao Y. Association between preoperative albumin and length of hospital stay in non-cardiac surgery patients with pulmonary hypertension: A secondary retrospective analysis. Medicine. 2024;103(23):e38442.
45. Al-Hussaniy HA, Al-Samydai A, Hajleh MN, Mayyas A, Oraibi AI. Selection and Progress of drugs for treating Dementia. Research Journal of Pharmacy and Technology. 2024; 17(4): 1674-8.
46. Roy LD, Kumar J, JAYS J, Krishnamurthy G, Gour P, Arland SE. Novel Resveratrol Analogues With Aromatic Hetero Moieties: Designing, One-Pot Synthesis And In Vitro Biological Evaluation. Farmacia. 2023; 71(1): 130–143
47. Tilinca Mc, Antal C, Balint A, Sălcudean A, Varga A. The Newest Therapeutically Approach Of" Diabesity" Using Glp-1 Ra Molecules: Impact Of The Oral Formulation. Farmacia. 2023; 71(1): 1–10
48. Nadiah S, Djabir Yy, Arsyad Ma, Rahmi N. The Cardioprotective Effect Of Extra Virgin Olive Oil And Virgin Coconut Oil On Isoproterenol-Induced Myocardial Infarction In Rats. FARMACIA, 2023; 71(1): 194–204.
49. Tang N, Zhou Q, Liu S, Li K, Liu Z, Zhang Q, Sun H, Peng C, Hao J, Qi C. Development and trends in research on hypertension and atrial fibrillation: A bibliometric analysis from 2003 to 2022. Medicine. 2024; 103(21): e38264.
50. Girija M, Kokilavani N. Effectiveness of structured teaching programme on knowledge, attitude and practice among patients with hypertension. Asian Journal of Nursing Education and Research. 2014; 4(1): 136-9.
51. Devi S, Samaga LN. Effect of transcendental meditation on stress and blood pressure among patients with systemic hypertension. Asian Journal of Nursing Education and Research. 2015; 5(1): 151-6. DOI: 10.5958/2349-2996.2015.00032.4
52. Patidar U, Patel H. A Study to assess The Effectiveness of Structured Teaching programme on Knowledge regarding prevention of stroke among Hypertensive patients in selected Hospitals of Mehsana District. Asian Journal of Nursing Education and Research. 2020; 10(1): 89-92. DOI: 10.5958/2349-2996.2020.00020.8
53. Kalaiselvi G, Savithri K. Effectiveness of Yoga therapy on mild pregnancy induced hypertension. Asian Journal of Nursing Education and Research. 2021; 11(1): 11-4. DOI: 10.5958/2349-2996.2021.00004.5
54. Mary AS, Devi SS, Devi LD. Effectiveness of structured teaching programme on knowledge regarding warning signs and prevention of stroke among hypertensive patients in selected hospitals at Bangalore. Asian Journal of Nursing Education and Research. 2022; 12(3): 313-6. DOI: 10.52711/2349-2996.2022.00065
55. Kumar S, Chavda N. A Review on Analytical Method Development and Validation for the Simultaneous Estimation of Rosuvastatin and Fimasartan in Bulk and its Pharmaceuticle Dosage Form. Asian Journal of Pharmaceutical Analysis. 2023; 13(3): 197-204. DOI: 10.52711/2231-5675.2023.00032
56. Mane AK, Chaware VJ. To assess causality, severity and preventability of adverse drug reactions of amlodipine in the treatment of hypertension. Asian Journal of Research in Chemistry. 2023; 16(1): 39-2. DOI: 10.52711/0974-4150.2023.00007
57. Kaushal Patidar, Shalini Kalal. A Study to assess the effectiveness of Video Assisted Teaching on knowledge regarding prevention of Stroke among Hypertensive Patients in selected Hospitals of Mehsana. Int. J. of Advances in Nur. Management. 2019; 7(2): 89-90. DOI: 10.5958/2454-2652.2019.00022.2
58. Al-Hussaniy HA. The effect of MicroRNA-409-3p for treatment and response to tumor proliferation of lung cancer cell lines (in vitro). Asian Pacific Journal of Cancer Prevention. 2022; 23(9): 3151-3156. DOI: 10.31557/APJCP.2022.23.9.3151.
59. Jesna Joy K, Philo Resmi, Angela Gnanadurai, Anand M. K. Effect of Video assisted teaching on knowledge and practice for prevention of Hypertensive renal diseases among patients with hypertension. Int. J. of Advances in Nur. Management. 2021; 9(2): 216-221. DOI: 10.5958/2454-2652.2021.00049.4
60. Abu Hajleh MN, AL‐Samydai A, Al‐Dujaili EA. Nano, micro particulate and cosmetic delivery systems of polylactic acid: A mini review. Journal of Cosmetic Dermatology. 2020; 19(11): 2805-11. DOI: 10.1111/jocd.13696
61. Al‐Halaseh LK, Al‐Adaileh S, Mbaideen A, Hajleh MN, Al‐Samydai A, Zakaraya ZZ, Dayyih WA. Implication of parabens in cosmetics and cosmeceuticals: Advantages and limitations. Journal of Cosmetic Dermatology. 2022; 21(8): 3265-71. DOI: 10.1111/jocd.14775
62. Samah Hammoud, Arige Boubou, Nisrin Kaddar. Antihypertensive effect of Dapagliflozin in Type II diabetic patients with Hypertension. Research Journal of Pharmacy and Technology. 2024; 17(2): 827-3. DOI: 10.52711/0974-360X.2024.00128