Author(s): Kanishka Lakhmani, Rita Lala

Email(s): rr.lala@kmkcp.edu.in

DOI: 10.52711/0974-360X.2024.00711   

Address: Kanishka Lakhmani1, Rita Lala2*
1PhD Scholar, Prin. K.M. Kundnani College of Pharmacy, Cuffe Parade, Mumbai, Maharashtra, India.
2Associate Professor, Dept. of Pharmaceutics, Prin. K. M. Kundnani College of Pharmacy, Cuffe Parade, Mumbai, Maharashtra, India.
*Corresponding Author

Published In:   Volume - 17,      Issue - 9,     Year - 2024


ABSTRACT:
Changes in nails are not only a concern for aesthetic appeal but also can be a window to an internal problem or disease. Delay in taking therapy for nail problems can aggravate the condition and drastically affect performance of task of everyday life, hampering the overall wellbeing of human. Onychoschizia, onychomycosis, paronychia, nail psoriasis, longitudinal melanonychia, are usual nail problems observed in medical practice, originating from infections, swelling or injuries of nails. Accurate diagnosis can be done through nail surface microscopy, computed tomography, biopsy and fungal studies. Nail disease management needs personalized therapy. Root cause for the problem such as ceasing the drug causing nail problems or surgical intervention can be done. Appropriate manicure and methods to reduce harm to the injured nails is a key aspect. Nail disorders can occur irrespective of age. Most of the nail problems due to infections. This review article enlists the details of types of nail disorders and recent treatment avenues.


Cite this article:
Kanishka Lakhmani, Rita Lala. Drug Delivery Through Nails: An Overview. Research Journal of Pharmacy and Technology. 2024; 17(9):4608-2. doi: 10.52711/0974-360X.2024.00711

Cite(Electronic):
Kanishka Lakhmani, Rita Lala. Drug Delivery Through Nails: An Overview. Research Journal of Pharmacy and Technology. 2024; 17(9):4608-2. doi: 10.52711/0974-360X.2024.00711   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-9-72


REFERENCES:
1.    G.V. Gupchup et.al. Structural characteristics and permeability properties of human nail. J. Cosmet Sci. 1999; 50: 363–385.
2.    Pradnya Palekar Shanbhag et.al. Drug delivery through nails: Present and future. New Horizons in Translational Medicine 2017; 3: 252–263. http://dx.doi.org/10.1016/j.nhtm.2017.01.002
3.    K.A. Walters et al. Permeability characteristics of the human nail plate. Int J. Cosmet Sci. 1983; 5: 231–246. https://doi.org/10.1111/j.1467-2494.1983.tb00348.x
4.    S. Murdan,. Drug delivery to the nail following topical application. Int J. Pharm. 2002; 236: 1–26. https://doi.org/10.1016/S0378-5173(01)00989-9
5.    S. Khanna et.al. Pharmacotherapeutic principles of Ungual drug delivery System. Int J. Drug Dev. Res. 2012; 4(3): 9–18.
6.    R. Baran et.al. A Text Atlas of Nail Disorders. 3 rd ed., Taylor & Francis Group, London, 2003.
7.    A.K. Gupta et.al. Ciclopirox nail lacquer solution 8% in the 21st century. J.Am. Acad. Dermatol. 2000; 43(4): 100–106. https://doi.org/10.1067/mjd.2000.109068
8.    S. Firoz et.al.Transungual drug delivery System – Areview.  Int. J. Innov. Drug Discov. 2011; 1:  9–14.
9.    R. Elkeeb et.al.Transungual drug delivery: current status. Int J. Pharm. 2009; 384: 1–8. https://doi.org/10.1016/j.ijpharm.2009.10.002
10.    D. Pandhi et.al. Nail avulsions: Indications and methods. Indian J. Dermatol Venereol. Leprol. 2012; 78: 299–308. 10.4103/0378-6323.95444.
11.    P. Chouhan et.al. Hydration of nail plate: a novel screening modelfortransungual drug permeation enhancers. Int J. Pharm. 2012; 436: 179–182. 10.1016/j.ijpharm.2012.06.020.
12.    Uwe Wollina et al. The Diagnosis and Treatment of Nail Disorders. Dtsch Arztebl Int. 2016; 113: 29-30, 509–518. 10.3238/arztebl.2016.0509
13.    Tainá Kreutz et al. Recent Patents on Permeation Enhancers for Drug Delivery Through Nails. Recent Patents on Drug Delivery & Formulation. 2019; 13: 203-218. 10.2174/1872211313666191030155837
14.    S. Murdan. Nail varnish as a drug delivery vehicle. 29-39 Brunswick Square, London.
15.    D. Hussan et.al. Transungual drug delivery-a novel approach of unique features. Indo American Journal of Pharmaceutical Research. 2013; 3(6): 4460–4469. 10.1044/1980-iajpr.00301
16.    P. T. Kumar et. al. Transungual drug delivery: apromising rote to treat nail disorders. International Journal ofPharmaceutical Research. 2013; 2: 22–23.
17.    Aditya K Gupta. Novel investigational therapies for onychomycosis: an update. Expert Opinion on Investigational Drugs. 2016. 10.1517/13543784.2016.1142529
18.    Debra K.  et. al. Optimal diagnosis and management of common nail disorders. Ann Med. 2022; 54(1): 694–712. 10.1080/07853890.2022.2044511.
19.    Bhavesh S. Barot et al.Drug Delivery to the Nail: Therapeutic Options and Challenges for Onychomycosis. Critical Reviews™ in Therapeutic Drug Carrier Systems, 2014; 31(6): 459–494. 10.1615/CritRevTherDrugCarrierSyst.2014008464.
20.    Vivek B. Rajendra et al. Transungual Drug Delivery: An Overview. Journal of Applied Pharmaceutical Science.  2012; 2(1):  203-209.
21.    Spoon-shaped-concave-nails-causes-and-mechanisms-of-pathogenesisavailableonlinehttps://www.vinmec.com/en/news/health-news/general-health-check.
22.    Nail-psoriasis available online https://www.healthline.com/health.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank

Journal Policies & Information


Recent Articles




Tags


Not Available