Author(s):
Pushpa Prasad Gupta, Chanchal Sahu, Shashikant Chandrakar, Rahul Yadav, Amit Roy
Email(s):
chanchalsahu1432@gmail.com
DOI:
10.52711/0974-360X.2024.00710 
Address:
Pushpa Prasad Gupta1, Chanchal Sahu2*, Shashikant Chandrakar3, Rahul Yadav4, Amit Roy1
1Chhatrapati Shivaji Institute of Pharmacy, Durg [C.G.]
2Columbia College of Pharmacy, Raipur [C.G.]
3Columbia Institute of Pharmacy, Raipur [C.G.]
4Gracious College of Pharmacy, Raipur [C.G.]
*Corresponding Author
Published In:
Volume - 17,
Issue - 9,
Year - 2024
ABSTRACT:
Moringa oleifera [M. olifera] is an indigenous plant of India. It is used in various diseases in different forms. In current study ethanolic extract of bark of M. olifera was used to formulate an ointment with white soft paraffin. Burn wound model was used to evaluate wound healing potential of M. olifera. Second-degree burns were created using a spatula [1 cm diameter] in wistar albino rat. 5 group’s were made, randomly, of wistar rats, i.e. positive control [treated with ointment base], negative control [with no treatment], Test I and II [Ointment at 5% and 10% ethanolic extract of M. olifera bark], Standard drug treated group. Parameters that were used for evaluating the activity were the percentage of wound contraction and histopathology of skin. The result showed dose dependent activity on contraction of wound. In study of histopathology it was observed that period of epithelialization got shortened and significant increase in periods of granulation tissue formation M. oleifera treated groups when compared to untreated control groups. These results represent that the M. olifera can be useful as a excellent therapeutic instrument in the management of burn wounds. Additional characterization is required for identifying the chemical constituents responsible for wound healing.
Cite this article:
Pushpa Prasad Gupta, Chanchal Sahu, Shashikant Chandrakar, Rahul Yadav, Amit Roy. Assessment of Moringa oleifera’s Efficacy in Promoting Burn Wound Healing in Wistar Rats: A Preclinical Evaluation. Research Journal of Pharmacy and Technology. 2024; 17(9):4601-7. doi: 10.52711/0974-360X.2024.00710
Cite(Electronic):
Pushpa Prasad Gupta, Chanchal Sahu, Shashikant Chandrakar, Rahul Yadav, Amit Roy. Assessment of Moringa oleifera’s Efficacy in Promoting Burn Wound Healing in Wistar Rats: A Preclinical Evaluation. Research Journal of Pharmacy and Technology. 2024; 17(9):4601-7. doi: 10.52711/0974-360X.2024.00710 Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-9-71
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