Author(s):
Kartikey T. Jagtap, Anuradha R. Mulik, Sushama S. Pawar, Suresh D. Jagtap
Email(s):
chiritatml@rediffmail.com
DOI:
10.52711/0974-360X.2024.00702 
Address:
Kartikey T. Jagtap1, Anuradha R. Mulik1, Sushama S. Pawar2, Suresh D. Jagtap1*
1Department of Herbal Medicine, Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth (Deemed to be University), Pune-Satara Road, Pune, Maharashtra, India-411043.
2Department of Zoology, Yashwantrao Mohite Arts Science and Commerce College, Bharati Vidyapeeth University, Paud Road, Erandavane, Pune, Maharashtra, India-411038.
*Corresponding Author
Published In:
Volume - 17,
Issue - 9,
Year - 2024
ABSTRACT:
The Ayurvedic pharmacopeia recognizes Vidanga (Embelia ribes Burf. f.) and identifies similarities, particularly in the active compound Embelin, morphological characteristics, and biochemical potential, with Embelia tsjeriam-cottam (Roem. & Schult.) A. DC. Given the side effects associated with modern treatments for gastric ulcers, this study explores the potential of Embelia species as an anti-ulcerogenic agent. Fruit extracts of Embelia ribes (Er) and Embelia tsjeriam-cottam (Et) were orally administered to rats for a fourteen-day period after ulcer induction. Stomach mucosal lesions were examined both macroscopically and histopathologically. The study also evaluated the extract’s efficacy in terms of oxidative stress biomarkers and antioxidant enzymes. The results confirm the anti-ulcerogenic potential of Embelia ribes, followed by Embelia tsjeriam-cottam fruit extracts, as evidenced by a reduction in ulcerated and hemorrhagic lesions. Additionally, both extracts exhibited in-vitro a-chymotrypsin inhibitory activity. Notably, there were non-significant changes observed in parameters such as Percent Body Weight Gain (BWG), daily food consumption, water ingestion, and various biochemical parameters. In rats subjected to ethanol-induced ulcers, treatment with omeprazole or Er and Et fruit extracts substantially reduced the Ulcer Index (UI) and modulated Glutathione (GSH) and Malondialdehyde (MDA) enzyme levels. However, non-significant changes were observed in Catalase (CAT) activity across all groups. Importantly, ulcer treatment resulted in a substantial reduction in both stomach mucosal Gastric Mucosal Glutathione (GPx) and Superoxide Dismutase Enzyme Activity (SOD). This study highlights the significant ulcer-healing efficacy of Embelia tsjeriam-cottam (Et) and Embelia ribes (Er) suggesting its potential for use in various herbal preparations, with the need for further validation studies.
Cite this article:
Kartikey T. Jagtap, Anuradha R. Mulik, Sushama S. Pawar, Suresh D. Jagtap. In vitro and In vivo Comparative Evaluation of Fruit Extracts from Embelia tsjeriam-cottam and Embelia ribes on Ethanol-Induced Gastric Ulcer in Rats. Research Journal of Pharmacy and Technology. 2024; 17(9):4543-1. doi: 10.52711/0974-360X.2024.00702
Cite(Electronic):
Kartikey T. Jagtap, Anuradha R. Mulik, Sushama S. Pawar, Suresh D. Jagtap. In vitro and In vivo Comparative Evaluation of Fruit Extracts from Embelia tsjeriam-cottam and Embelia ribes on Ethanol-Induced Gastric Ulcer in Rats. Research Journal of Pharmacy and Technology. 2024; 17(9):4543-1. doi: 10.52711/0974-360X.2024.00702 Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-9-63
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