Author(s):
Lintang Cahyaning Ratri, Shidi Laras Pramudito, Bendix Samarta Witarto, Jongky Hendro Prajitno, Citrawati Dyah Kencono Wungu, Hermina Novida, Robert Dwitama Adiwinoto
Email(s):
jongky-h-p@fk.unair.ac.id
DOI:
10.52711/0974-360X.2024.00700 
Address:
Lintang Cahyaning Ratri1, Shidi Laras Pramudito1, Bendix Samarta Witarto1, Jongky Hendro Prajitno2*, Citrawati Dyah Kencono Wungu3,4, Hermina Novida2, Robert Dwitama Adiwinoto2
1Medical Program, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
2Department of Internal Medicine, Faculty of Medicine, Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya, Indonesia.
3Department of Physiology and Medical Biochemistry, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
4Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia
*Corresponding Author
Published In:
Volume - 17,
Issue - 9,
Year - 2024
ABSTRACT:
Objectives: Over the years, the increasing number of diabetes mellitus cases has drawn special attention in which diabetes screening becomes a crucial effort to prevent burdensome complications. The current practice of screening and monitoring diabetes mellitus requires an invasive method to retrieve blood samples, which may be inconvenient to patients. However, no meta-analysis has examined hyperglycemia conditions in nail protein compositions. Therefore, this study aims to identify the potential of nail glycation examination as a non-invasive diagnostic tool in diabetes mellitus. Methods: A systematic search was conducted in electronic databases and the collected literatures then were further reviewed. A bivariate random-effect meta-analysis was conducted to estimate the pooled parameter of diagnostic values. The study protocol was registered in PROSPERO CRD42021267633. Results: The five studies with a total of 885 participants included in this study yielded a pooled result of sensitivity and specificity reaching 87% (95% CI: 0.57?0.97) and 93% (95% CI: 0.69?0.99), with the area under the curve of 96% (95% CI: 0.94?0.97). Conclusion: In conclusion, nail glycation examination has good potential as a non-invasive diagnostic tool in diagnosing diabetes mellitus.
Cite this article:
Lintang Cahyaning Ratri, Shidi Laras Pramudito, Bendix Samarta Witarto, Jongky Hendro Prajitno, Citrawati Dyah Kencono Wungu, Hermina Novida, Robert Dwitama Adiwinoto. The Potential of Nail Glycation Examination for Detecting Diabetes Mellitus: A Systematic Review and Meta-Analysis. Research Journal of Pharmacy and Technology. 2024; 17(9):4528-4. doi: 10.52711/0974-360X.2024.00700
Cite(Electronic):
Lintang Cahyaning Ratri, Shidi Laras Pramudito, Bendix Samarta Witarto, Jongky Hendro Prajitno, Citrawati Dyah Kencono Wungu, Hermina Novida, Robert Dwitama Adiwinoto. The Potential of Nail Glycation Examination for Detecting Diabetes Mellitus: A Systematic Review and Meta-Analysis. Research Journal of Pharmacy and Technology. 2024; 17(9):4528-4. doi: 10.52711/0974-360X.2024.00700 Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-9-61
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